Evidence map›Paper›PMID 29415788›Full record

ArticlePsychological medicine2018

Children with ADHD symptoms show deficits in reactive but not proactive inhibition, irrespective of their formal diagnosis.

Branko M van Hulst, Patrick de Zeeuw, Chantal Vlaskamp, Yvonne Rijks, Bram B Zandbelt, Sarah Durston

Open access · hybridAbstract read
In one paragraph

Article in Psychological medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed, 1 pooled it
3.9field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 1 synthesis or guideline pooled it, 47 citations in OpenAlex.

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  6. Learning-based cognitive control in ADHD: a multicentric study.Journal of child psychology and psychiatry, and allied disciplines · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Branko M van HulstNICHE Lab,Department of Psychiatry,Brain Center Rudolf Magnus,University Medical Center Utrecht,Utrecht,The Netherlands.
Patrick de ZeeuwNICHE Lab,Department of Psychiatry,Brain Center Rudolf Magnus,University Medical Center Utrecht,Utrecht,The Netherlands.
Chantal VlaskampNICHE Lab,Department of Psychiatry,Brain Center Rudolf Magnus,University Medical Center Utrecht,Utrecht,The Netherlands.
Yvonne RijksNICHE Lab,Department of Psychiatry,Brain Center Rudolf Magnus,University Medical Center Utrecht,Utrecht,The Netherlands.
Bram B ZandbeltDonders Institute for Brain,Cognition and Behavior,Radboud University,Nijmegen,The Netherlands.
Sarah DurstonNICHE Lab,Department of Psychiatry,Brain Center Rudolf Magnus,University Medical Center Utrecht,Utrecht,The Netherlands.
University Medical Center Utrecht · NLRadboud University Nijmegen · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAttenuated inhibitory control is one of the most robust findings in the neuropsychology of attention-deficit/hyperactivity disorder (ADHD). However, it is unclear whether this represents a deficit in outright stopping (reactive inhibition), whether it relates to a deficit in anticipatory response slowing (proactive inhibition), or both. In addition, children with other development disorders, such as autism spectrum disorder (ASD), often have symptoms of inattention, impulsivity, and hyperactivity similar to children with ADHD. These may relate to similar underlying changes in inhibitory processing.

methodsIn this study, we used a modified stop-signal task to dissociate reactive and proactive inhibition. We included not only children with ADHD, but also children primarily diagnosed with an ASD and high parent-rated levels of ADHD symptoms.

resultsWe replicated the well-documented finding of attenuated reactive inhibition in children with ADHD. In addition, we found a similar deficit in children with ASD and a similar level of ADHD symptoms. In contrast, we found no evidence for deficits in proactive inhibition in either clinical group.

conclusionsThese findings re-emphasize the role of reactive inhibition in children with ADHD and ADHD symptoms. Moreover, our findings stress the importance of a trans-diagnostic approach to the relationship between behavior and neuropsychology.

Indexed as

Proactive InhibitionReactive InhibitionAttention Deficit Disorder with HyperactivityChildExecutive FunctionHumansMalePsychomotor PerformanceAttention-deficit disorder with hyperactivitychildcognitive controlneuropsychologyproactive inhibitionreactive inhibitiontrans-diagnostic

Identifiers

PMID29415788
PMCPMC6190063
OpenAlexW2792777054

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.