SynthesisRespiratory research2018
Characterizing undiagnosed chronic obstructive pulmonary disease: a systematic review and meta-analysis.
Synthesis in Respiratory research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed.
- Decoding Diagnostic Delay in COPD: An Integrative Analysis of Missed Opportunities, Clinical Risk Profiles, and Targeted Detection Strategies in Primary Care.Diagnostics (Basel, Switzerland) · 2025Article
- Mobile Phone Auscultation Accurately Diagnoses Chronic Obstructive Pulmonary Disease Using Nonlinear Respiratory Biofluid Dynamics.Diagnostics (Basel, Switzerland) · 2025Article
- Comparison of long-term outcome between muscle sparing and non-muscle sparing surgical techniques in rib plating.European journal of trauma and emergency surgery : official publication of the European Trauma Society · 2025Observational
- A Qualitative Study of Aboriginal Peoples' Health Care Experiences With Chronic Obstructive Pulmonary Disease.Qualitative health research · 2025Article
- Recent Advances in Medicinal Chemistry of Phosphodiesterase 7 Inhibitors and their Potential Therapeutic Applications.Recent advances in inflammation & allergy drug discovery · 2025Review
- Impact of observability period on the classification of COPD diagnosis timing among Medicare beneficiaries with lung cancer.PLOS digital health · 2024Article
- Effectiveness of immunoglobulin replacement therapy in preventing infections in patients with chronic obstructive pulmonary disease: a systematic review.Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology · 2024Article
- Association between COPD and Stage of Lung Cancer Diagnosis: A Population-Based Study.Current oncology (Toronto, Ont.) · 2023Article
- COPD awareness among the Syrian community: population-based study.Scientific reports · 2023Article
- Current Progress of COPD Early Detection: Key Points and Novel Strategies.International journal of chronic obstructive pulmonary disease · 2023Review
- PUMA screening tool to detect COPD in high-risk patients in Chinese primary care-A validation study.PloS one · 2022Article
- Expression and Related Mechanisms of miR-100 and TRIB2 in COPD Patients.Journal of healthcare engineering · 2022Article
- Underdiagnosis, false diagnosis and treatment of COPD in a selected population in Northern Greece.The European journal of general practice · 2021Observational
- Self-reported COPD Medication Use and Adherence in the COPD Foundation Patient- Powered Registry Network.Chronic obstructive pulmonary diseases (Miami, Fla.) · 2021Article
- Underdiagnosis of obstructive lung disease: findings from the French CONSTANCES cohort.BMC pulmonary medicine · 2021Article
- Cost Effectiveness of Case Detection Strategies for the Early Detection of COPD.Applied health economics and health policy · 2021Article
- Active screening for COPD among hospitalized smokers - a feasibility study.Therapeutic advances in chronic disease · 2020Article
- The socioeconomic burden of chronic lung disease in low-resource settings across the globe - an observational FRESH AIR study.Respiratory research · 2019Observational
- Network-based logistic regression integration method for biomarker identification.BMC systems biology · 2018Article
- The diagnostic performance of patient symptoms in screening for COPD.Respiratory research · 2018Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
backgroundA significant proportion of patients with chronic obstructive pulmonary disease (COPD) remain undiagnosed. Characterizing these patients can increase our understanding of the 'hidden' burden of COPD and the effectiveness of case detection interventions.
methodsWe conducted a systematic review and meta-analysis to compare patient and disease factors between patients with undiagnosed persistent airflow limitation and those with diagnosed COPD. We searched MEDLINE and EMBASE for observational studies of adult patients meeting accepted spirometric definitions of COPD. We extracted and pooled summary data on the proportion or mean of each risk factor among diagnosed and undiagnosed patients (unadjusted analysis), and coefficients for the adjusted association between risk factors and diagnosis status (adjusted analysis).
resultsTwo thousand eighty-three records were identified through database searching and 16 articles were used in the meta-analyses. Diagnosed patients were less likely to have mild (v. moderate to very severe) COPD (odds ratio [OR] 0.30, 95%CI 0.24-0.37, 6 studies) in unadjusted analysis. This association remained significant but its strength was attenuated in the adjusted analysis (OR 0.72, 95%CI 0.58-0.89, 2 studies). Diagnosed patients were more likely to report respiratory symptoms such as wheezing (OR 3.51, 95%CI 2.19-5.63, 3 studies) and phlegm (OR 2.16, 95% CI 1.38-3.38, 3 studies), had more severe dyspnea (mean difference in modified Medical Research Council scale 0.52, 95%CI 0.40-0.64, 3 studies), and slightly greater smoking history than undiagnosed patients. Patient age, sex, current smoking status, and the presence of coughing were not associated with a previous diagnosis.
conclusionsUndiagnosed patients had less severe airflow obstruction and fewer respiratory symptoms than diagnosed patients. The lower disease burden in undiagnosed patients may significantly delay the diagnosis of COPD.
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