Evidence map›Paper›PMID 29415708›Full record

SynthesisBMC oral health2018

IL-13 -1112 polymorphism and periodontitis susceptibility: a meta-analysis.

Wenbo Zhang, Pu Xu, Zhuogeng Chen, Yanan Cheng, Xiaoni Li, Qiuhua Mao

Abstract readMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in BMC oral health, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
  2. What Has Immunology Brought to Periodontal Disease in Recent Years?Archivum immunologiae et therapiae experimentalis · 2022
    Review
  3. Article
  4. Review
  5. Article
  6. Article
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Wenbo ZhangDepartment of Oral Implantation, Affiliated Haikou Hospital,Xiangya Medical School, Central South University, Hainan Provincial Stomatology Centre, Haikou, 570208, Hainan Province, China.
Pu XuDepartment of Oral Implantation, Affiliated Haikou Hospital,Xiangya Medical School, Central South University, Hainan Provincial Stomatology Centre, Haikou, 570208, Hainan Province, China. hnxupu@163.com.
Zhuogeng ChenDepartment of Oral Implantation, Affiliated Haikou Hospital,Xiangya Medical School, Central South University, Hainan Provincial Stomatology Centre, Haikou, 570208, Hainan Province, China.
Yanan ChengDepartment of Oral Implantation, Affiliated Haikou Hospital,Xiangya Medical School, Central South University, Hainan Provincial Stomatology Centre, Haikou, 570208, Hainan Province, China.
Xiaoni LiDepartment of Oral Implantation, Affiliated Haikou Hospital,Xiangya Medical School, Central South University, Hainan Provincial Stomatology Centre, Haikou, 570208, Hainan Province, China.
Qiuhua MaoDepartment of Oral Implantation, Affiliated Haikou Hospital,Xiangya Medical School, Central South University, Hainan Provincial Stomatology Centre, Haikou, 570208, Hainan Province, China.

Funding

Key research and development projects in Hainan Province ZDYF2016018
6 · The paper itself

Abstract

backgroundSeveral studies have examined the association between the IL-13 -1112C/T polymorphism and the risk of periodontitis. However, these studies have reached different conclusions. The aim of the current study was to investigate the link between this IL-13 -1112 polymorphism and susceptibility to periodontitis.

methodsWe utilized electronic databases, including the CNKI (China National Knowledge Infrastructure), Wanfang, PubMed, Embase, and Cochrane Library databases, to manually search for relevant research published through November 30, 2016. The Chinese and English terms used to search the literature included "periodontitis", "periodontal disease", "IL 13", "IL-13", and "interleukin-13". In accordance with our inclusion criteria, we selected studies that involved case-control trials. All of these case-control trials described their objectives, design and specific statistical methods. For all included studies, odds ratios (ORs) and 95% confidence intervals (95% CIs) were provided or could be calculated from the study data. The quality of the included literature was evaluated using the Newcastle-Ottawa scale (NOS). STATA 12.0 was used to calculate the sizes of the combined effects and conduct a sensitivity analysis of the results.

resultsOur meta-analysis included 4 articles representing 5 case-control studies with a total of 710 cases and 671 control subjects. The meta-analysis results indicated that the CC vs TT model, CT vs TT model and TT vs CT + CC model (CC VS TT: OR = 0.615, 95% CI = 0.395-0.957; CT vs TT: OR = 0.518, 95% CI = 0.323-0.830; and TT vs CT + CC: OR = 1.739, 95% CI = 1.130-2.676) were significant in five IL-13 -1112 gene polymorphism and periodontitis susceptibility models. Subgroup analysis indicated that the CC vs TT, CT vs TT and TT vs CT + CC models were significant in the chronic periodontitis (CP) group, whereas no significant differences were found in the five aggressive periodontitis (AgP) group models. The sensitivity analysis showed that dropping any single study did not affect the pooled analysis results.

conclusionThe IL-13 -1112 polymorphism may be associated with susceptibility to periodontitis. The IL-13 -1112 gene polymorphism may be associated with susceptibility to CP but not to AgP. Thus, large-scale, multi-ethnic case-control trials are still warranted.

Indexed as

Aggressive PeriodontitisGenetic Predisposition to DiseaseHumansInterleukin-13PeriodontitisPolymorphism, Single NucleotideInterleukin-13Gene polymorphismInterleukin-13Meta-analysisPeriodontitis

Identifiers

PMID29415708
PMCPMC5803991

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.