Evidence map›Paper›PMID 29415563›Full record

Trial reportJournal of diabetes science and technology2018

Body Mass Index Effect on Differing Responses to Psychological Stress in Blood Glucose Dynamics in Patients With Type 1 Diabetes.

Basak Ozaslan, Stephen D Patek, Jesse H Grabman, Jaclyn A Shepard, Eyal Dassau, Marc D Breton, Yogish C Kudva, Sue A Brown, Ananda Basu, Jordan E Pinsker and 2 more

Abstract readClinical TrialMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Journal of diabetes science and technology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Trial
  2. Review
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Basak Ozaslan1 University of Virginia, Systems and Information Engineering, Charlottesville, VA, USA.
Stephen D Patek1 University of Virginia, Systems and Information Engineering, Charlottesville, VA, USA.
Jesse H Grabman3 University of Virginia, Department of Psychology, Charlottesville, VA, USA.
Jaclyn A Shepard4 University of Virginia, Behavioral Medicine Center, Charlottesville, VA, USA.
Eyal Dassau5 Harvard University, Harvard John A. Paulson School of Engineering and Applied Sciences, Cambridge, MA, USA.
Marc D Breton2 University of Virginia, Center for Diabetes Technology, Charlottesville, VA, USA.
Yogish C Kudva6 Endocrine Research Unit, Mayo Clinic, Rochester, MN, USA.
Sue A Brown2 University of Virginia, Center for Diabetes Technology, Charlottesville, VA, USA.
Ananda Basu2 University of Virginia, Center for Diabetes Technology, Charlottesville, VA, USA.
Jordan E Pinsker7 Sansum Diabetes Research Institute, Clinical Research, Santa Barbara, CA, USA.ORCID 0000-0003-4080-9034
Francis J Doyle5 Harvard University, Harvard John A. Paulson School of Engineering and Applied Sciences, Cambridge, MA, USA.
Linda Gonder-Frederick2 University of Virginia, Center for Diabetes Technology, Charlottesville, VA, USA.

Funding

Mayo Clinic Center for Translational Science ActivitiesUL1TR000135 · NCATS · MAYO CLINIC ROCHESTER · PI KHOSLA, SUNDEEP · 2012 to 2015
$41.2M
Integrated Approaches to Close the Loop in Type 1 DiabetesR01DK085516 · NIDDK · UNIVERSITY OF VIRGINIA · PI BASU, ANANDA · 2009 to 2021
$6.5M
Ambulatory Artificial Pancreas: merging physiology, behavior, and control designDP3DK094331 · NIDDK · UNIVERSITY OF CALIFORNIA SANTA BARBARA · PI BASU, ANANDA, DOYLE, FRANCIS J · 2011 to 2014
$4.6M
Closed-loop Artificial Pancreas: Algorithm Engineering and Clinical EvaluationR01DK085628 · NIDDK · UNIVERSITY OF CALIFORNIA SANTA BARBARA · PI DOYLE, FRANCIS J, JOVANOVIC, LOIS · 2009 to 2013
$3.4M
NCATS NIH HHS UL1 TR000135NIDDK NIH HHS DP3 DK094331NIDDK NIH HHS R01 DK085516NIDDK NIH HHS R01 DK085628
6 · The paper itself

Abstract

objectiveThe objective was to investigate the relationship of body mass index (BMI) to differing glycemic responses to psychological stress in patients with type 1 diabetes.

methodsContinuous blood glucose monitor (CGM) data were collected for 1 week from a total of 37 patients with BMI ranging from 21.5-39.4 kg/m

resultsAnalyses showed that patient BMI likely moderated stress related glycemic changes. Linear mixed effect model results were significant for the stress-BMI interaction on both behavioral and behavior-independent glycemic changes. Across participants, under stress, an increase was observed in daily carbohydrate intake and effectiveness index at higher BMI. There was no significant interactive effect on daily insulin or average BG.

conclusionFindings suggest that (1) stress has both behavioral and nonbehavioral glycemic effects on T1D patients and (2) the direction and magnitude of these effects are potentially influenced by level of stress and patient BMI. Possibly responsible for these observed effects are T1D/BMI related alterations in endocrine response.

Indexed as

Body Mass IndexAdultBlood GlucoseBlood Glucose Self-MonitoringDiabetes Mellitus, Type 1FemaleGlycemic IndexHumansHypoglycemic AgentsInsulinMaleMiddle AgedPancreas, ArtificialStress, PsychologicalBlood GlucoseHypoglycemic AgentsInsulinbody mass indexeffectiveness indexglycemic variabilitystresstype 1 diabetes

Identifiers

PMID29415563
PMCPMC6154247

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.