Evidence map›Paper›PMID 29415554›Full record

ArticleAIDS care2018

The relationship between gastrointestinal symptom attribution, bothersomeness, and antiretroviral adherence among adults with HIV.

Holly Swan, Joel I Reisman, Sarah E McDannold, Mark E Glickman, D Keith McInnes, Allen L Gifford

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in AIDS care, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Holly Swana Edith Nourse Rogers Memorial VA , Bedford , MA , USA.
Joel I Reismana Edith Nourse Rogers Memorial VA , Bedford , MA , USA.
Sarah E McDannolda Edith Nourse Rogers Memorial VA , Bedford , MA , USA.
Mark E Glickmanc Department of Statistics , Harvard University , Cambridge , MA , USA.
D Keith McInnesa Edith Nourse Rogers Memorial VA , Bedford , MA , USA.
Allen L Giffordd CHOIR - HSR&D Center of Innovation , VA Boston Healthcare System , Boston , MA , USA.

Funding

Implementing Computerized Clinical Assessment of HIV Patient AdherenceR01MH076911 · NIMH · BOSTON UNIVERSITY MEDICAL CAMPUS · PI GIFFORD, ALLEN L · 2007 to 2011
$2.5M
TISSUE PLASMINOGEN ACTIVATOR FROM THE HUMAN ENDOTHELIUMR01HL040435 · NHLBI · SCRIPPS RESEARCH INSTITUTE · PI LEVIN, EUGENE G · 1990 to 1994
–
NHLBI NIH HHS R01 HL040435NIMH NIH HHS R01 MH076911
6 · The paper itself

Abstract

Patients who attribute their symptoms to HIV medications, rather than disease, may be prone to switching antiretrovirals (ARVs) and experience poor retention/adherence to care. Gastrointestinal (GI) symptoms (e.g., nausea/vomiting) are often experienced as a side effect of ARVs, but little is known about the relationship of symptom attribution and bothersomeness to adherence. We hypothesized that attribution of a GI symptom to ARVs is associated with a reduction in adherence, and that this relationship is moderated by the bothersomeness of the symptom. Data for our analysis come from the pre-randomization enrollment period of a larger study testing an adherence improvement intervention. Analyses revealed that patients with diarrhea who attributed the symptom to ARVs (compared to those who did not) had significantly worse adherence. We did not find a significant moderating effect of bothersomeness on this relationship. Incorporating patient beliefs about causes of symptoms into clinical care may contribute to improved symptom and medication management, and better adherence.

Indexed as

Medication AdherenceAdultAnti-HIV AgentsDiarrheaFemaleHIV InfectionsHumansMaleMiddle AgedNauseaVomitingAnti-HIV Agentsadherenceantiretroviral medicationHIV/AIDSMEMSsymptom attribution

Identifiers

PMID29415554
PMCPMC6166244

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.