Evidence map›Paper›PMID 29415476›Full record

ReviewInternational journal of molecular sciences2018

The Impact of Aging on Cardio and Cerebrovascular Diseases.

Carmine Izzo, Albino Carrizzo, Antonia Alfano, Nicola Virtuoso, Mario Capunzo, Mariaconsiglia Calabrese, Eros De Simone, Sebastiano Sciarretta, Giacomo Frati, Marco Oliveti and 5 more

Open access · goldAbstract readReview
In one paragraph

Review in International journal of molecular sciences, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 63 papers.

0numbers the graph read from it
0cells of the map it votes in
63citing papers in PubMed
7.7field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

63 citing papers in PubMed, 120 citations in OpenAlex.

  1. Trial
  2. Article
  3. The role of vascular risk factors in white matter tract microstructure: a multi-cohort study in older adults.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026
    Article
  4. Vascular contribution to cognitive impairment and dementia (VCID): proceedings of 2025 workshop of the Jackson Laboratory.Mammalian genome : official journal of the International Mammalian Genome Society · 2026
    Article
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3 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 4 institutions in 1 country.

Carmine IzzoDepartement of Medicine and Surgery, University of Salerno, 84081 Salerno, Italy. carmine.izzo93@gmail.com.
Albino CarrizzoVascular Physiopathology Unit, IRCCS Neuromed, 86077 Pozzilli, Italy. albino.carrizzo@gmail.com.
Antonia AlfanoHeart Department, A.O.U. "San Giovanni di Dio e Ruggi d'Aragona", 84131 Salerno, Italy. antonia.alfano@sangiovannieruggi.it.
Nicola VirtuosoDepartment of Cardiovascular Medicine, A.O.U. Federico II, 80131 Naples, Italy. n.virtuoso@hotmail.com.
Mario CapunzoDepartement of Medicine and Surgery, University of Salerno, 84081 Salerno, Italy. mcapunzo@unisa.it.
Mariaconsiglia CalabreseRehabilitation Department, A.O.U. "San Giovanni di Dio e Ruggi d'Aragona", 84131 Salerno, Italy.
Eros De SimoneHeart Department, A.O.U. "San Giovanni di Dio e Ruggi d'Aragona", 84131 Salerno, Italy. eros.desimone@sangiovannieruggi.it.
Sebastiano SciarrettaVascular Physiopathology Unit, IRCCS Neuromed, 86077 Pozzilli, Italy. sebastiano.sciarretta@uniroma1.it.
Giacomo FratiVascular Physiopathology Unit, IRCCS Neuromed, 86077 Pozzilli, Italy. fraticello@inwind.it.
Marco OlivetiDepartement of Medicine and Surgery, University of Salerno, 84081 Salerno, Italy. olivetimarco@yahoo.it.ORCID 0000-0002-9458-4523
Antonio DamatoVascular Physiopathology Unit, IRCCS Neuromed, 86077 Pozzilli, Italy. antonio.damato85@libero.it.
Mariateresa AmbrosioVascular Physiopathology Unit, IRCCS Neuromed, 86077 Pozzilli, Italy. mattyambr@gmail.com.
Francesco De CaroDepartement of Medicine and Surgery, University of Salerno, 84081 Salerno, Italy. fdecaro@unisa.it.ORCID 0000-0001-9659-9940
Paolo RemondelliDepartement of Medicine and Surgery, University of Salerno, 84081 Salerno, Italy. premondelli@unisa.it.
Carmine VecchioneDepartement of Medicine and Surgery, University of Salerno, 84081 Salerno, Italy. cvecchione@unisa.it.
University of Salerno · ITIstituto Neurologico Mediterraneo · ITOspedali Riuniti San Giovanni di Dio e Ruggi d'Aragona · ITFederico II University Hospital · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A growing number of evidences report that aging represents the major risk factor for the development of cardio and cerebrovascular diseases. Understanding Aging from a genetic, biochemical and physiological point of view could be helpful to design a better medical approach and to elaborate the best therapeutic strategy to adopt, without neglecting all the risk factors associated with advanced age. Of course, the better way should always be understanding risk-to-benefit ratio, maintenance of independence and reduction of symptoms. Although improvements in treatment of cardiovascular diseases in the elderly population have increased the survival rate, several studies are needed to understand the best management option to improve therapeutic outcomes. The aim of this review is to give a 360° panorama on what goes on in the fragile ecosystem of elderly, why it happens and what we can do, right now, with the tools at our disposal to slow down aging, until new discoveries on aging, cardio and cerebrovascular diseases are at hand.

Indexed as

AgingAge FactorsAnimalsBlood VesselsCardiovascular DiseasesCerebrovascular DisordersDisease SusceptibilityEndotheliumGenetic Predisposition to DiseaseHeartHumansOxidative StressRiskVasodilationagingcardiovascular diseasesgeneticsmolecular mechanisms

Identifiers

PMID29415476
PMCPMC5855703
OpenAlexW2794092650

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.