Evidence map›Paper›PMID 29415469›Full record

ArticleInternational journal of molecular sciences2018

CircSMARCA5 Inhibits Migration of Glioblastoma Multiforme Cells by Regulating a Molecular Axis Involving Splicing Factors SRSF1/SRSF3/PTB.

Davide Barbagallo, Angela Caponnetto, Matilde Cirnigliaro, Duilia Brex, Cristina Barbagallo, Floriana D'Angeli, Antonio Morrone, Rosario Caltabiano, Giuseppe Maria Barbagallo, Marco Ragusa and 3 more

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 120 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
120citing papers in PubMed, 1 pooled it
9.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

120 citing papers in PubMed, 1 synthesis or guideline pooled it, 192 citations in OpenAlex.

  1. La Tunisie medicale · 2024
    Pooled it
  2. Review
  3. Article
  4. Review
  5. Review
  6. Review
  7. PTBP1 and Cancer: From RNA Regulation to Therapeutic Potential.Journal of cellular and molecular medicine · 2025
    Review
  8. Review
  9. Review
  10. Review
  11. Article
  12. Article
  13. Review
  14. Review
  15. Review
  16. Review
  17. Article
  18. Review
  19. Review
  20. Article

60 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 2 institutions in 2 countries.

Davide BarbagalloDepartment of Biomedical and Biotechnological Sciences-Section of Biology and Genetics, University of Catania, 95123 Catania, Italy. dbarbaga@unict.it.ORCID 0000-0001-5331-4554
Angela CaponnettoDepartment of Biomedical and Biotechnological Sciences-Section of Biology and Genetics, University of Catania, 95123 Catania, Italy. caponnettoangela@gmail.com.
Matilde CirnigliaroDepartment of Biomedical and Biotechnological Sciences-Section of Biology and Genetics, University of Catania, 95123 Catania, Italy. matildecirnigliaro@gmail.com.
Duilia BrexDepartment of Biomedical and Biotechnological Sciences-Section of Biology and Genetics, University of Catania, 95123 Catania, Italy. duiliabrex@gmail.com.
Cristina BarbagalloDepartment of Biomedical and Biotechnological Sciences-Section of Biology and Genetics, University of Catania, 95123 Catania, Italy. barbagallocristina@gmail.com.ORCID 0000-0002-6769-4516
Floriana D'AngeliDepartment of Biomedical and Biotechnological Sciences-Section of Biology and Genetics, University of Catania, 95123 Catania, Italy. floriana.dangeli@hotmail.it.
Antonio MorroneDepartment of Medical, Surgical Sciences and Advanced Technologies and Biotechnological Sciences G.F. Ingrassia, University of Catania, 95123 Catania, Italy. morant592@libero.it.
Rosario CaltabianoDepartment of Medical, Surgical Sciences and Advanced Technologies and Biotechnological Sciences G.F. Ingrassia, University of Catania, 95123 Catania, Italy. rosario.caltabiano@unict.it.ORCID 0000-0001-8591-8010
Giuseppe Maria BarbagalloDepartment of Medical, Surgical Sciences and Advanced Technologies and Biotechnological Sciences G.F. Ingrassia, University of Catania, 95123 Catania, Italy. gbarbagallo@unict.it.
Marco RagusaDepartment of Biomedical and Biotechnological Sciences-Section of Biology and Genetics, University of Catania, 95123 Catania, Italy. mragusa@unict.it.
Cinzia Di PietroDepartment of Biomedical and Biotechnological Sciences-Section of Biology and Genetics, University of Catania, 95123 Catania, Italy. dipietro@unict.it.
Thomas Birkballe HansenDepartment of Molecular Biology and Genetics (MBG), Aarhus University, 8000 Aarhus C, Denmark. tbh@mbg.au.dk.
Michele PurrelloDepartment of Biomedical and Biotechnological Sciences-Section of Biology and Genetics, University of Catania, 95123 Catania, Italy. purrello@unict.it.
University of Catania · ITAarhus University · DK

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Circular RNAs (circRNAs) have recently emerged as a new class of RNAs, highly enriched in the brain and very stable within cells, exosomes and body fluids. To analyze their involvement in glioblastoma multiforme (GBM) pathogenesis, we assayed the expression of twelve circRNAs, physiologically enriched in several regions of the brain, through real-time PCR in a cohort of fifty-six GBM patient biopsies and seven normal brain parenchymas. We focused on hsa_circ_0001445 (circSMARCA5): it was significantly downregulated in GBM biopsies as compared to normal brain tissues (

Indexed as

Cell-Free Nucleic AcidsRNAAgedAged, 80 and overAlternative SplicingCell LineCell Line, TumorCell MovementCell ProliferationCell SurvivalComputational BiologyFemaleGene Expression ProfilingGene Expression Regulation, NeoplasticGlioblastomaHumansCell-Free Nucleic AcidsPolypyrimidine Tract-Binding ProteinRNASerine-Arginine Splicing FactorsSRSF1 protein, humanSRSF3 protein, humancell migrationcircRNAsglioblastoma multiformeRNA binding proteinssplicing

Identifiers

PMID29415469
PMCPMC5855702
OpenAlexW2788015434

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.