Evidence map›Paper›PMID 29415463›Full record

ArticleInternational journal of molecular sciences2018

Changes in DNA Methylation from Age 18 to Pregnancy in Type 1, 2, and 17 T Helper and Regulatory T-Cells Pathway Genes.

Sabrina Iqbal, Gabrielle A Lockett, John W Holloway, S Hasan Arshad, Hongmei Zhang, Akhilesh Kaushal, Sabarinath R Tetali, Nandini Mukherjee, Wilfried J J Karmaus

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.6field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 18 citations in OpenAlex.

  1. Preeclampsia as a Study Model for Aging: The Klotho Gene Paradigm.International journal of molecular sciences · 2025
    Review
  2. Review
  3. Article
  4. Review
  5. Article
  6. Review
  7. Review
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

Sabrina IqbalDivision of Epidemiology, Biostatistics and Environmental Health, School of Public Health, University of Memphis, Memphis, 301 Robison Hall, 3825 DeSoto Avenue Memphis, TN 38152, USA. sabrina1.iqbal@gmail.com.
Gabrielle A LockettHuman Development and Health, Faculty of Medicine, University of Southampton, Southampton SO17 1BJ, UK. G.A.Lockett@soton.ac.uk.
John W HollowayHuman Development and Health, Faculty of Medicine, University of Southampton, Southampton SO17 1BJ, UK. J.W.Holloway@soton.ac.uk.ORCID 0000-0001-9998-0464
S Hasan ArshadFaculty of Medicine, University of Southampton, Southampton SO17 1BJ, UK. S.H.Arshad@soton.ac.uk.
Hongmei ZhangDivision of Epidemiology, Biostatistics and Environmental Health, School of Public Health, University of Memphis, Memphis, 301 Robison Hall, 3825 DeSoto Avenue Memphis, TN 38152, USA. hzhang6@memphis.edu.
Akhilesh KaushalDivision of Epidemiology, Biostatistics and Environmental Health, School of Public Health, University of Memphis, Memphis, 301 Robison Hall, 3825 DeSoto Avenue Memphis, TN 38152, USA. akaushl1@memphis.edu.
Sabarinath R TetaliDivision of Epidemiology, Biostatistics and Environmental Health, School of Public Health, University of Memphis, Memphis, 301 Robison Hall, 3825 DeSoto Avenue Memphis, TN 38152, USA. sabarinath5889@gmail.com.
Nandini MukherjeeDivision of Epidemiology, Biostatistics and Environmental Health, School of Public Health, University of Memphis, Memphis, 301 Robison Hall, 3825 DeSoto Avenue Memphis, TN 38152, USA. nmkhrjee@memphis.edu.
Wilfried J J KarmausDivision of Epidemiology, Biostatistics and Environmental Health, School of Public Health, University of Memphis, Memphis, 301 Robison Hall, 3825 DeSoto Avenue Memphis, TN 38152, USA. karmaus1@memphis.edu.ORCID 0000-0003-2684-1492
University of Memphis · USUniversity of Southampton · GBDavid Hide Asthma and Allergy Research Centre · GB

Funding

Transgenerational epigenetic inheritance of allergy in a multigenerational cohortR01AI091905 · NIAID · UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA · PI KARMAUS, WILFRIED JJ · 2011 to 2015
$2.7M
Medical Research Council G0900747NIAID NIH HHS R01 AI091905Wellcome Trust
6 · The paper itself

Abstract

To succeed, pregnancies need to initiate immune biases towards T helper 2 (Th2) responses, yet little is known about what establishes this bias. Using the Illumina 450 K platform, we explored changes in DNA methylation (DNAm) of Th1, Th2, Th17, and regulatory T cell pathway genes before and during pregnancy. Female participants were recruited at birth (1989), and followed through age 18 years and their pregnancy (2011-2015). Peripheral blood DNAm was measured in 245 girls at 18 years; from among these girls, the DNAm of 54 women was repeatedly measured in the first (weeks 8-21,

Indexed as

DNA MethylationGene Expression RegulationSignal TransductionAdolescentAdultAllelesCpG IslandsFemaleGene Expression ProfilingGestational AgeHumansPregnancyTh17 CellsTh1 CellsTh2 CellsT-Lymphocytes, Helper-InducerDNA methylationEpigeneticsgenespregnancyregulatory T cellsTh17 biasTh1 biasTh2 bias

Identifiers

PMID29415463
PMCPMC5855699
OpenAlexW2788915006

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.