ArticlePLoS biology2018
Empirical evidence that metabolic theory describes the temperature dependency of within-host parasite dynamics.
Article in PLoS biology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers.
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Who cites it
46 citing papers in PubMed.
- Coinfections Dampen the Effects of Temperature on Host-Parasite Interactions.Ecology letters · 2026Article
- A flexible model for thermal performance curves.Ecology · 2026Article
- How to write a scientific paper in fifteen steps.PLoS computational biology · 2025Article
- Review
- Parasites of the hermit crab Pagurus hirsutiusculus; distribution, prevalence, and thermal ecology.PloS one · 2025Article
- Early warning signals do not predict a warming-induced experimental epidemic.PLOS global public health · 2025Article
- Cold snaps lead to a 5-fold increase or a 3-fold decrease in disease proliferation depending on the baseline temperature.BMC biology · 2024Article
- Myxospore density of Kudoa inornata varies significantly within symmetrical white muscle tissue replicates of its fish host, the spotted seatrout, Cynoscion nebulosus.Parasitology research · 2024Article
- Coinfection frequency in water flea populations is a mere reflection of parasite diversity.Communications biology · 2024Article
- High temperatures and low humidity promote the occurrence of microsporidians (Microsporidia) in mosquitoes (Culicidae).Parasites & vectors · 2024Article
- Into the danger zone: How the within-host distribution of parasites controls virulence.Ecology letters · 2024Article
- Increased virulence due to multiple infection inParasitology · 2024Article
- Estimating the magnitude and sensitivity of energy fluxes for stickleback hosts andEcology and evolution · 2023Article
- High temperatures augment inhibition of parasites by a honey bee gut symbiont.Applied and environmental microbiology · 2023Article
- Short-term temperature fluctuations increase disease in a Daphnia-parasite infectious disease system.PLoS biology · 2023Article
- Biological Invasions Affect Resource Processing in Aquatic Ecosystems: The Invasive AmphipodBiology · 2023Article
- Infection burdens and virulence under heat stress: ecological and evolutionary considerations.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2023Review
- Host-driven temperature dependence of Deformed wing virus infection in honey bee pupae.Communications biology · 2023Article
- Constraining nonlinear time series modeling with the metabolic theory of ecology.Proceedings of the National Academy of Sciences of the United States of America · 2023Review
- Population genetic analysis of the microsporidium Ordospora colligata reveals the role of natural selection and phylogeography on its extremely compact and reduced genome.G3 (Bethesda, Md.) · 2023Article
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The complexity of host-parasite interactions makes it difficult to predict how host-parasite systems will respond to climate change. In particular, host and parasite traits such as survival and virulence may have distinct temperature dependencies that must be integrated into models of disease dynamics. Using experimental data from Daphnia magna and a microsporidian parasite, we fitted a mechanistic model of the within-host parasite population dynamics. Model parameters comprising host aging and mortality, as well as parasite growth, virulence, and equilibrium abundance, were specified by relationships arising from the metabolic theory of ecology. The model effectively predicts host survival, parasite growth, and the cost of infection across temperature while using less than half the parameters compared to modeling temperatures discretely. Our results serve as a proof of concept that linking simple metabolic models with a mechanistic host-parasite framework can be used to predict temperature responses of parasite population dynamics at the within-host level.
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