SynthesisPLoS neglected tropical diseases2018
The association between obesity and dengue severity among pediatric patients: A systematic review and meta-analysis.
Synthesis in PLoS neglected tropical diseases, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04377451 (Metformin as Adjunctive Therapy in Overweight and Obese Patients With Dengue), which is not on this map. Cited by 36 papers, 4 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Metformin as Adjunctive Therapy in Overweight and Obese Patients With Dengue: an Open-label Safety and Tolerability Trial
Who cites it
36 citing papers in PubMed, 4 syntheses or guidelines pooled it, 87 citations in OpenAlex.
- Association between mental health and chronic obstructive pulmonary disease (COPD) outcomes: systematic review and meta-analysis.BMJ open respiratory research · 2026Pooled it
- Obesity as a clinical predictor for severe manifestation of dengue: a systematic review and meta-analysis.BMC infectious diseases · 2023Pooled it
- Prevalence of dementia in ischaemic or mixed stroke populations: systematic review and meta-analysis.Journal of neurology, neurosurgery, and psychiatry · 2022Pooled it
- Pooled it
- Safety and tolerability of metformin in overweight and obese patients with dengue: An open-label clinical trial (MeDO).PLoS neglected tropical diseases · 2025Trial
- Clinical and haematological correlates of severe dengue using 2023 epidemic data: A multicentre tertiary hospital-based analysis from Dhaka, Bangladesh.PLoS neglected tropical diseases · 2026Article
- Observational
- Impact of projected climate and socioeconomic scenarios on state-wise annual dengue incidence in India using ensemble models.PLoS neglected tropical diseases · 2026Article
- Pathogenic dengue virus TW2015 strain infection triggers anaerobic glycolysis and enhances mortality in diabetic mice.Journal of virology · 2025Article
- Severe dengue in adults: Clinical features from the 2022 dengue outbreak at a Vietnamese tertiary hospital.PLoS neglected tropical diseases · 2025Article
- Gastrointestinal Manifestations and Prognostic Factors for Severe Dengue in Thai Children.The American journal of tropical medicine and hygiene · 2025Article
- Obesity Is Associated With Increased Pediatric Dengue Virus Infection and Disease: A 9-Year Cohort Study in Managua, Nicaragua.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2024Article
- Article
- Is the rise in childhood obesity rates leading to an increase in hospitalizations due to dengue?PLoS neglected tropical diseases · 2024Article
- Obesity is associated with increased pediatric dengue virus infection and disease: A 9-year cohort study in Managua, Nicaragua.medRxiv : the preprint server for health sciences · 2024Article
- Atopic Dermatitis Immune Dysregulation as Dengue Predisposing Factor.Journal of inflammation research · 2024Review
- Allergies, body mass, and hospitalization due to arbovirus infection: A prospective surveillance study in Machala, Ecuador.Epidemiology and infection · 2023Article
- Dietary Patterns and Anti-Flavivirus IgG Seroconversion in Colombian Children.The American journal of tropical medicine and hygiene · 2023Article
- Development and Validation of a Bedside Dengue Severity Score for Predicting Severe Dengue in Children.Indian pediatrics · 2023Article
- Is new dengue vaccine efficacy data a relief or cause for concern?NPJ vaccines · 2023Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSevere dengue infection often has unpredictable clinical progressions and outcomes. Obesity may play a role in the deterioration of dengue infection due to stronger body immune responses. Several studies found that obese dengue patients have a more severe presentation with a poorer prognosis. However, the association was inconclusive due to the variation in the results of earlier studies. Therefore, we conducted a systematic review and meta-analysis to explore the relationship between obesity and dengue severity.
methodsWe performed a systematic search of relevant studies on Ovid (MEDLINE), EMBASE, the Cochrane Library, Web of Science, Scopus and grey literature databases. At least two authors independently conducted the literature search, selecting eligible studies, and extracting data. Meta-analysis using random-effects model was conducted to compute the pooled odds ratio with 95% confidence intervals (CI).
findingsWe obtained a total of 13,333 articles from the searches. For the final analysis, we included a total of fifteen studies among pediatric patients. Three cohort studies, two case-control studies, and one cross-sectional study found an association between obesity and dengue severity. In contrast, six cohort studies and three case-control studies found no significant relationship between obesity and dengue severity. Our meta-analysis revealed that there was 38 percent higher odds (Odds Ratio = 1.38; 95% CI:1.10, 1.73) of developing severe dengue infection among obese children compared to non-obese children. We found no heterogeneity found between studies. The differences in obesity classification, study quality, and study design do not modify the association between obesity and dengue severity.
conclusionThis review found that obesity is a risk factor for dengue severity among children. The result highlights and improves our understanding that obesity might influence the severity of dengue infection.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.