Evidence map›Paper›PMID 29414872›Full record

ArticleMolecules (Basel, Switzerland)2018

Suramin-Induced Neurotoxicity: Preclinical Models and Neuroprotective Strategies.

David von der Ahe, Petra Huehnchen, Mustafa Balkaya, Sarah Peruzzaro, Matthias Endres, Wolfgang Boehmerle

Open access · goldAbstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.0field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 26 citations in OpenAlex.

  1. Article
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  7. Metabolite profiling ofFrontiers in cellular and infection microbiology · 2023
    Article
  8. Metabolic Pathways ofPharmaceutics · 2022
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 2 countries.

David von der AheCharité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Klinik und Hochschulambulanz für Neurologie, Chariteplatz 1, 10117 Berlin, Germany. david.von-der-ahe@charite.de.
Petra HuehnchenCharité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Klinik und Hochschulambulanz für Neurologie, Chariteplatz 1, 10117 Berlin, Germany. petra.huehnchen@charite.de.ORCID 0000-0002-6825-7270
Mustafa BalkayaBurke-Cornell Medical Research Institute, White Plains, NY 10605, USA. mgbalkaya@yahoo.com.
Sarah PeruzzaroField Neurosciences Institute Laboratory for Restorative Neurology, Central Michigan University, Mt. Pleasant, MI 48859, USA. stperuzzaro@gmail.com.
Matthias EndresCharité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Klinik und Hochschulambulanz für Neurologie, Chariteplatz 1, 10117 Berlin, Germany. Matthias.endres@charite.de.
Wolfgang BoehmerleCharité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Klinik und Hochschulambulanz für Neurologie, Chariteplatz 1, 10117 Berlin, Germany. wolfgang.boehmerle@charite.de.ORCID 0000-0001-7195-3894
Humboldt-Universität zu Berlin · DECentral Michigan University · USCornell University · USGerman Center for Neurodegenerative Diseases · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Suramin is a trypan blue analogon originally developed to treat protozoan infections, which was found to have diverse antitumor effects. One of the most severe side effects in clinical trials was the development of a peripheral sensory-motor polyneuropathy. In this study, we aimed to investigate suramin-induced neuropathy with a focus on calcium (Ca

Indexed as

AnimalsCalciumCalcium ChannelsCell SurvivalDisease Models, AnimalDose-Response Relationship, DrugDrug Evaluation, PreclinicalGanglia, SpinalMiceModels, AnimalNeuronsNeuroprotectionNeuroprotective AgentsNeurotoxinsPolyneuropathiesSuraminCalciumCalcium ChannelsNeuroprotective AgentsNeurotoxinsSuramincalciumneuroprotectionsuraminTRP channelsvoltage-gated calcium channels

Identifiers

PMID29414872
PMCPMC6017835
OpenAlexW2789693458

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.