Evidence map›Paper›PMID 29414776›Full record

ArticleThe Journal of biological chemistry2018

Identification of a staphylococcal complement inhibitor with broad host specificity in equid

Nienke W M de Jong, Manouk Vrieling, Brandon L Garcia, Gerrit Koop, Matt Brettmann, Piet C Aerts, Maartje Ruyken, Jos A G van Strijp, Mark Holmes, Ewan M Harrison and 2 more

Open access · hybridAbstract read
In one paragraph

Article in The Journal of biological chemistry, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
3.3field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 51 citations in OpenAlex.

  1. Article
  2. Characterisation ofToxins · 2025
    Article
  3. Frontiers in veterinary science · 2025
    Article
  4. Review
  5. Review
  6. Article
  7. Article
  8. Review
  9. Article
  10. Article
  11. Group BJournal of immunology (Baltimore, Md. : 1950) · 2022
    Article
  12. Gut Virome: Role and Distribution in Health and Gastrointestinal Diseases.Frontiers in cellular and infection microbiology · 2022
    Review
  13. Review
  14. Article
  15. Article
  16. Article
  17. The Role of Macrophages inFrontiers in immunology · 2020
    Review
  18. Article
  19. Article
  20. Staphylococci: Evolving Genomes.Microbiology spectrum · 2019
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 5 institutions in 3 countries.

Nienke W M de JongFrom the Department of Medical Microbiology, University Medical Center Utrecht, Utrecht University, 3584 CX Utrecht, The Netherlands.
Manouk VrielingFrom the Department of Medical Microbiology, University Medical Center Utrecht, Utrecht University, 3584 CX Utrecht, The Netherlands.
Brandon L Garciathe Department of Biochemistry and Molecular Biophysics, Kansas State University, Manhattan, Kansas 66506.
Gerrit Koopthe Department of Farm Animal Health, Faculty of Veterinary Medicine, Utrecht University, 3584 CL Utrecht, The Netherlands.
Matt Brettmannthe Department of Biochemistry and Molecular Biophysics, Kansas State University, Manhattan, Kansas 66506.
Piet C AertsFrom the Department of Medical Microbiology, University Medical Center Utrecht, Utrecht University, 3584 CX Utrecht, The Netherlands.
Maartje RuykenFrom the Department of Medical Microbiology, University Medical Center Utrecht, Utrecht University, 3584 CX Utrecht, The Netherlands.
Jos A G van StrijpFrom the Department of Medical Microbiology, University Medical Center Utrecht, Utrecht University, 3584 CX Utrecht, The Netherlands.
Mark Holmesthe Department of Veterinary Medicine, University of Cambridge, Cambridge CB3 0ES, United Kingdom, and.
Ewan M Harrisonthe Department of Medicine, University of Cambridge, Addenbrooke's Hospital, Cambridge CB2 0QQ, United Kingdom.
Brian V Geisbrechtthe Department of Biochemistry and Molecular Biophysics, Kansas State University, Manhattan, Kansas 66506.
Suzan H M RooijakkersFrom the Department of Medical Microbiology, University Medical Center Utrecht, Utrecht University, 3584 CX Utrecht, The Netherlands, s.h.m.rooijakkers@umcutrecht.nl.
Utrecht University · NLKansas State University · USAddenbrooke's Hospital · GBUniversity Medical Center Utrecht · NLUniversity of Cambridge · GB

Funding

Novel Staphylococcal Inhibitors of Neutrophil Granule EnzymesR01GM121511 · NIGMS · KANSAS STATE UNIVERSITY · PI GEISBRECHT, BRIAN V · 2017 to 2020
$1.2M
Cheminformatic Discovery of Alternative Pathway C3 Pro-Convertase InhibitorsR21AI113552 · NIAID · KANSAS STATE UNIVERSITY · PI GEISBRECHT, BRIAN V · 2014 to 2015
$439k
European Research Council 639209Medical Research Council G1001787Medical Research Council MR/P007201/1NIAID NIH HHS R21 AI113552NIGMS NIH HHS R01 GM121511Wellcome TrustWellcome Trust WT098600
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

AnimalsComplement C3bComplement C3-C5 ConvertasesComplement Inactivator ProteinsHemolysisHorsesHost SpecificityHumansPhagocytosisProtein BindingStaphylococcal InfectionsStaphylococcus aureusSwineVirulence FactorsComplement C3bComplement C3-C5 ConvertasesComplement Inactivator ProteinsVirulence Factorscomplement systemequinehost adaptationhost-pathogen interactionimmune evasioninnate immunitymicrobial pathogenesisSCINStaphylococcus aureus (S. aureus)

Identifiers

PMID29414776
PMCPMC5868266
OpenAlexW2789520806

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.