ArticleThe Journal of biological chemistry2018
Glycation of human serum albumin impairs binding to the glucagon-like peptide-1 analogue liraglutide.
Article in The Journal of biological chemistry, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 35 citations in OpenAlex.
- An Orthogonal Framework for Higher-Order Structural and In Vitro Functional Comparability of Chemically Synthesized Liraglutide Relative to an rDNA-Origin Reference Product.Pharmaceutical research · 2026Article
- Type 2 diabetes mellitus as a state of altered drug pharmacokinetic-pharmacodynamic parameters: an update on recent developments and clinical implications.Therapeutic advances in endocrinology and metabolism · 2026Review
- Liraglutide-Conjugated Poly(methyl vinyl ether-ACS applied materials & interfaces · 2025Article
- Article
- Interaction between albumin originating from persons with uncontrolled diabetes mellitus type 2 and food antioxidants.ADMET & DMPK · 2025Article
- A nomogram including admission serum glycated albumin/albumin ratio to predict mortality in patients with severe fever with thrombocytopenia syndrome.BMC infectious diseases · 2024Article
- Aldosterone, Methylglyoxal, and Glycated Albumin Interaction with Macrophage Cells Affects Their Viability, Activation, and Differentiation.ACS omega · 2024Article
- Inhibition of toxic metal-alpha synuclein interactions by human serum albumin.Chemical science · 2024Article
- Crosstalk between Aldosterone and Glycation through Rac-1 Induces Diabetic Nephropathy.ACS omega · 2023Article
- Comprehensive profiling and kinetic studies of glycated lysine residues in human serum albumin.Analytical and bioanalytical chemistry · 2022Article
- Albumin Glycation Affects the Delivery of C-Peptide to the Red Blood Cells.ACS measurement science au · 2022Article
- Albumin Binds COVID-19 Spike 1 Subunit and Predicts In-Hospital Survival of Infected Patients-Possible Alteration by Glucose.Journal of clinical medicine · 2022Article
- A novel strategy for production of liraglutide precursor peptide and development of a new long-acting incretin mimic.PloS one · 2022Article
- Assessment of Vitamin D Metabolism in Patients with Cushing's Disease in Response to 150,000 IU Cholecalciferol Treatment.Nutrients · 2021Article
- How Does Glycation Affect Binding Parameters of the Albumin-Gliclazide System in the Presence of Drugs Commonly Used in Diabetes? In Vitro Spectroscopic Study.Molecules (Basel, Switzerland) · 2021Article
- Evaluation of Vitamin D Metabolism in Patients with Type 1 Diabetes Mellitus in the Setting of Cholecalciferol Treatment.Nutrients · 2020Article
- Article
Corrections and comments
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Authors and funding
14 authors at 6 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The long-acting glucagon-like peptide-1 analogue liraglutide has proven efficiency in the management of type 2 diabetes and also has beneficial effects on cardiovascular diseases. Liraglutide's protracted action highly depends on its capacity to bind to albumin via its palmitic acid part. However, in diabetes, albumin can undergo glycation, resulting in impaired drug binding. Our objective in this study was to assess the impact of human serum albumin (HSA) glycation on liraglutide affinity. Using fluorine labeling of the drug and
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Registered trials
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