Evidence map›Paper›PMID 29414681›Full record

ArticleCell metabolism2018

Metabolite-Induced Protein Expression Guided by Metabolomics and Systems Biology.

Martin Giera, Filipe Branco Dos Santos, Gary Siuzdak

Open access · bronzeAbstract read
In one paragraph

Article in Cell metabolism, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.5field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Article
  6. Review
  7. Identification of bioactive metabolites using activity metabolomics.Nature reviews. Molecular cell biology · 2019
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 3 institutions in 2 countries.

Martin GieraLeiden University Medical Center, Center for Proteomics and Metabolomics, Albinusdreef 2, 2300RC Leiden, the Netherlands. Electronic address: m.a.giera@lumc.nl.
Filipe Branco Dos SantosMolecular Microbial Physiology Group, Faculty of Science, Swammerdam Institute for Life Sciences, University of Amsterdam, Science Park 904, 1098 XH Amsterdam, the Netherlands.
Gary SiuzdakThe Scripps Research Institute, Scripps Center for Metabolomics and Mass Spectrometry, La Jolla, CA, USA. Electronic address: siuzdak@scripps.edu.
Leiden University Medical Center · NLScripps Research Institute · USUniversity of Amsterdam · NL

Funding

Metabolomics Technologies to Advance Biomedical ResearchR35GM130385 · NIGMS · SCRIPPS RESEARCH INSTITUTE, THE · PI GARY E SIUZDAK · 2019 to 2026
$3.9M
NIGMS NIH HHS R35 GM130385
6 · The paper itself

Abstract

Metabolomics combined with systems biology can be used to identify endogenous metabolites that modulate protein expression. Recent examples include the 2-fold enhancements of pertussis toxin protein in vaccine production and myelin basic protein expression in oligodendrocyte maturation; both applied a metabolomics-systems strategy to identify active metabolites.

Indexed as

MetabolomeMetabolomicsSystems BiologyCell DifferentiationOligodendrogliaProteinsProteins

Identifiers

PMID29414681
PMCPMC10243132
OpenAlexW2786799503

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.