Evidence map›Paper›PMID 29414638›Full record

Observational studyCancer epidemiology2018

Obesity surgery and risk of colorectal and other obesity-related cancers: An English population-based cohort study.

Ariadni Aravani, Amy Downing, James D Thomas, Jesper Lagergren, Eva J A Morris, Mark A Hull

Open access · hybridAbstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Cancer epidemiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed, 4 pooled it
3.3field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 4 syntheses or guidelines pooled it, 65 citations in OpenAlex.

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  4. Intentional weight loss, weight cycling, and endometrial cancer risk: a systematic review and meta-analysis.International journal of gynecological cancer : official journal of the International Gynecological Cancer Society · 2019
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 2 countries.

Ariadni AravaniLeeds Institute of Cancer & Pathology, University of Leeds, Worsley Building, Leeds, LS2 9NL, United Kingdom. Electronic address: a.aravani@leeds.ac.uk.
Amy DowningLeeds Institute of Cancer & Pathology, University of Leeds, Worsley Building, Leeds, LS2 9NL, United Kingdom. Electronic address: a.downing@leeds.ac.uk.
James D ThomasPublic Health England, Blenheim House, Duncombe St., Leeds, West Yorkshire, LS1 4PL, United Kingdom. Electronic address: james.thomas@phe.gov.uk.
Jesper LagergrenUpper Gastrointestinal Surgery, Department of Molecular Medicine and Surgery, Karolinska Institutet, Karolinska University Hospital, 17176 Stockholm, Sweden; Division of Cancer Studies, King's College London, WC2R 2LS, United Kingdom. Electronic address: Jesper.Lagergren@ki.se.
Eva J A MorrisLeeds Institute of Cancer & Pathology, University of Leeds, Worsley Building, Leeds, LS2 9NL, United Kingdom. Electronic address: e.morris@leeds.ac.uk.
Mark A HullLeeds Institute of Biomedical & Clinical Sciences, University of Leeds, Wellcome Trust Brenner Building, St. James's University Hospital, Leeds LS9 7TF, United Kingdom. Electronic address: m.a.hull@leeds.ac.uk.
University of Leeds · GBKarolinska University Hospital · SEPublic Health England · GB

Funding

Cancer Research UK C23434/A23706Medical Research Council MR/L01629X/1
6 · The paper itself

Abstract

backgroundThe association between obesity surgery (OS) and cancer risk remains unclear. We investigated this association across the English National Health Service. A population-based Swedish study has previously suggested that OS may increase the risk of developing colorectal cancer (CRC).

methodsA retrospective observational study of individuals who underwent OS (surgery cohort) or diagnosed with obesity, but had no OS (no-surgery cohort) (1997-2013) were identified using Hospital Episode Statistics. Subsequent diagnosis of CRC, breast, endometrial, kidney and lung cancer, as well as time 'at risk', were determined by linkage to National Cancer Registration & Analysis Service and Office of National Statistics data, respectively. Standardised incidence ratios (SIR) in relation to OS were calculated.

results1 002 607 obese patients were identified, of whom 3.9% (n = 39 747) underwent OS. In the no-surgery obese population, 3 237 developed CRC (SIR 1.12 [95% CI 1.08-1.16]). In those who underwent OS, 43 developed CRC (SIR 1.26 [95% CI 0.92-1.71]). The OS cohort demonstrated decreased breast cancer risk (SIR 0.76 [95% CI 0.62-0.92]), unlike the no surgery cohort (SIR 1.08 [95% CI 1.04-1.11]). Increased risk of endometrial and kidney cancer was observed in surgery and no-surgery cohorts.

conclusionsCRC risk is increased in individuals diagnosed as obese. Prior obesity surgery was not associated with an increased CRC risk. However, the OS population was small, with limited follow-up. Risk of breast cancer after OS is reduced compared with the obese no-surgery population, while the risk of endometrial and kidney cancers remained elevated after OS.

Indexed as

Postoperative ComplicationsAdolescentAdultAgedAged, 80 and overBariatric SurgeryDigestive System Surgical ProceduresFemaleHumansIncidenceMaleMiddle AgedNeoplasmsObesityRetrospective StudiesRisk FactorsBariatric surgeryColon cancerObesityRectal cancer

Identifiers

PMID29414638
PMCPMC5865073
OpenAlexW2783368412

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.