ReviewEpilepsy & behavior : E&B2018
A modern epilepsy surgery treatment algorithm: Incorporating traditional and emerging technologies.
Review in Epilepsy & behavior : E&B, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
48 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Efficacy of neurosurgical interventions for epilepsy in polymicrogyria: A systematic review.Epilepsia open · 2026Pooled it
- Deep brain stimulation of the thalamus for intractable epilepsy (FRANCE study): A randomized clinical trial.Epilepsia · 2026Trial
- The dynamic functional connectivity peak index: Detection of interictal epileptic activity with fMRI.Epilepsia · 2026Article
- Lateralization of Bilateral Temporal Lobe Epilepsy After Vagus Nerve Stimulation Surgery.Cureus · 2026Article
- Expanding the scope of pediatric epilepsy surgery: Access, indications, and outcomes in a modern cohort.Epilepsia open · 2026Article
- Risk factors for extra-axial hemorrhage during invasive monitoring using subdural electrodes.Neurosurgical review · 2026Article
- Responsive neurostimulation in children, adolescents, and young Adults-Longitudinal effectiveness and safety.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2026Article
- Collapse of interictal suppressive networks permits seizure spread.Brain : a journal of neurology · 2025Article
- AAV-mediated gene therapy for focal epilepsy by expressing neuropeptide Y and Y2 receptor in rodent and non-human primate hippocampus.Molecular therapy : the journal of the American Society of Gene Therapy · 2025Article
- Deep learning on brief interictal intracranial recordings can accurately characterize seizure onset zones.Epilepsia · 2025Article
- Cortico-cortical evoked potentials: Analytical techniques and emerging paradigms for epileptogenic zone localization.Epilepsia · 2025Review
- Can memory mapping via stereo-electroencephalography stimulation predict post-operative memory outcomes? A case report.Journal of neurology · 2025Article
- Surgical targeting of lateralizedEpilepsia · 2025Article
- The impact of resective epilepsy surgery on the brain network: evidence from post-surgical imaging.Brain : a journal of neurology · 2025Review
- Multiple subpial transections with concomitant responsive neurostimulation of the insula: illustrative case.Journal of neurosurgery. Case lessons · 2025Article
- Article
- Interictal neural fragility predicts seizure onset zone and surgical outcomes in drug-resistant epilepsy.PeerJ · 2025Article
- The interictal suppression hypothesis is the dominant differentiator of seizure onset zones in focal epilepsy.Brain : a journal of neurology · 2024Article
- The molecular genetics of PI3K/PTEN/AKT/mTOR pathway in the malformations of cortical development.Genes & diseases · 2024Review
- Indirect structural changes and reduced controllability after temporal lobe epilepsy resection.Epilepsia · 2024Article
Corrections and comments
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Authors and funding
1 author.
Funding
Abstract
Epilepsy surgery has seen numerous technological advances in both diagnostic and therapeutic procedures in recent years. This has increased the number of patients who may be candidates for intervention and potential improvement in quality of life. However, the expansion of the field also necessitates a broader understanding of how to incorporate both traditional and emerging technologies into the care provided at comprehensive epilepsy centers. This review summarizes both old and new surgical procedures in epilepsy using an example algorithm. While treatment algorithms are inherently oversimplified, incomplete, and reflect personal bias, they provide a general framework that can be customized to each center and each patient, incorporating differences in provider opinion, patient preference, and the institutional availability of technologies. For instance, the use of minimally invasive stereotactic electroencephalography (SEEG) has increased dramatically over the past decade, but many cases still benefit from invasive recordings using subdural grids. Furthermore, although surgical resection remains the gold-standard treatment for focal mesial temporal or neocortical epilepsy, ablative procedures such as laser interstitial thermal therapy (LITT) or stereotactic radiosurgery (SRS) may be appropriate and avoid craniotomy in many cases. Furthermore, while palliative surgical procedures were once limited to disconnection surgeries, several neurostimulation treatments are now available to treat eloquent cortical, bitemporal, and even multifocal or generalized epilepsy syndromes. An updated perspective in epilepsy surgery will help guide surgical decision making and lay the groundwork for data collection needed in future studies and trials.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.