Evidence map›Paper›PMID 29414505›Full record

ArticleClinical imaging

Inter-operator variability in compartmental kinetic analysis of

Sadek A Nehmeh, Jazmin Schwartz, Milan Grkovski, Ivan Yeung, Charles M Laymon, Mark Muzi, John L Humm

Abstract read
In one paragraph

Article in Clinical imaging. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Longitudinal PET imaging of tumor hypoxia during the course of radiotherapy.European journal of nuclear medicine and molecular imaging · 2018
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Sadek A NehmehWeill Cornell Medical College, New York, NY, United States. Electronic address: san28@med.cornell.edu.
Jazmin SchwartzDepartment of Medical Physics, Memorial Sloan Kettering Cancer Center, New York, NY, United States.
Milan GrkovskiDepartment of Medical Physics, Memorial Sloan Kettering Cancer Center, New York, NY, United States.
Ivan YeungDepartment of Medical Physics, Princess Margaret Cancer Center, Toronto, Ontario, Canada.
Charles M LaymonDepartments of Radiology and Bioengineering, University of Pittsburgh, Pittsburgh, PA, United States.
Mark MuziDepartment of Radiology, University of Washington, Seattle, WA, United States.
John L HummDepartment of Medical Physics, Memorial Sloan Kettering Cancer Center, New York, NY, United States.

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Nicholas D Socci · 1985 to 2026
$347.4M
VECTOR CORE FACILITYP30CA047904 · NCI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Jessie Nedrow · 1988 to 2026
$158.0M
ECOG-ACRIN-Based QIN Resource for Advancing Quantitative Cancer Imaging in Clinical TrialsU01CA190254 · NCI · ECOG-ACRIN MEDICAL RESEARCH FOUNDATION · PI SCHNALL, MITCHELL D. · 2015 to 2019
$3.2M
Core Laboratory for Advanced PET and MRI image analysisR50CA211270 · NCI · UNIVERSITY OF WASHINGTON · PI Mark Muzi · 2017 to 2026
$2.6M
Quantitative Biomarker Imaging for Early Therapy Response Assessment in CancerU01CA140230 · NCI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI MOUNTZ, JAMES M. · 2009 to 2013
$2.1M
Prognostic value of tumor hypoxia, as measured by 18F-FMISO Breath Hold PET/CTU01CA157442 · NCI · SLOAN-KETTERING INST CAN RESEARCH · PI CHAFT, JAMIE ERIN, HUMM, JOHN L · 2012 to 2014
$1.7M
NCI NIH HHS P30 CA008748NCI NIH HHS P30 CA047904NCI NIH HHS R50 CA211270NCI NIH HHS U01 CA140230NCI NIH HHS U01 CA157442NCI NIH HHS U01 CA190254
6 · The paper itself

Abstract

purposeTo assess the inter-operator variability in compartment analysis (CA) of dynamic-FMISO (dyn-FMISO) PET.

methodsStudy-I: Five investigators conducted CA for 23 NSCLC dyn-FMISO tumor time-activity-curves. Study-II: Four operators performed CA for four NSCLC dyn-FMISO datasets. Repeatability of Kinetic-Rate-Constants (KRCs) was assessed.

resultsStudy-I: Strong correlation (ICC > 0.9) and interchangeable results among operators existed for all KRCs. Study-II: Up to 103% variability in tumor segmentation, and weaker ICC in KRCs (ICC-V

conclusionsInter-operator variability in CA of dyn-FMISO was shown to be within statistical errors.

Indexed as

Carcinoma, Non-Small-Cell LungHumansLung NeoplasmsMisonidazolePositron-Emission TomographyRadiopharmaceuticalsfluoromisonidazoleMisonidazoleRadiopharmaceuticalsDynamic PETKinetic analysisVariability

Identifiers

PMID29414505
PMCPMC6059771

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.