Evidence map›Paper›PMID 29414272›Full record

Trial reportThe New England journal of medicine2018

Trial of Prazosin for Post-Traumatic Stress Disorder in Military Veterans.

Murray A Raskind, Elaine R Peskind, Bruce Chow, Crystal Harris, Anne Davis-Karim, Hollie A Holmes, Kimberly L Hart, Miles McFall, Thomas A Mellman, Christopher Reist and 8 more

2 registry-linked trialsOpen access · bronzeAbstract readMulticenter StudyRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in The New England journal of medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 151 papers, 16 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
151citing papers in PubMed, 16 pooled it
43.4field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00532493 phase3completednot on this map

CSP #563 - Prazosin and Combat Trauma PTSD (PACT)

TypeinterventionalSponsorVA Office of Research and DevelopmentRan2010 to 2013Enrolled304ConditionsPTSD, Sleep DisordersArmsprazosin, placebo
NCT03894345 phase1suspendednot on this mapstarted 2019, after this paper: background citation

Open Label 8-Week Study of Prazosin Use in Adults With Anxiety Disorders

TypeinterventionalSponsorUniversity of ManitobaRan2019 to 2023Enrolled20ConditionsAnxiety, Anxiety DisordersArmsPrazosin
3 · Its place in the literature

Who cites it

151 citing papers in PubMed, 16 syntheses or guidelines pooled it, 320 citations in OpenAlex.

  1. Pooled it
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  11. Pharmacotherapy for post traumatic stress disorder (PTSD).The Cochrane database of systematic reviews · 2022
    Pooled it
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  16. Position Paper for the Treatment of Nightmare Disorder in Adults: An American Academy of Sleep Medicine Position Paper.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2018
    Guideline
  17. Trial
  18. Trial
  19. Trial
  20. Trial

91 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

18 authors at 11 institutions in 1 country.

Murray A RaskindFrom the Veterans Affairs (VA) Northwest Network Mental Illness Research, Education, and Clinical Center (M.A.R., E.R.P., H.A.H., K.L.H., M.M.) and the Department of Psychiatry and Behavioral Sciences, University of Washington School of Medicine (M.A.R., E.R.P., M.M.), Seattle; VA Cooperative Studies Program Coordinating Center, Palo Alto (B.C., M.-C.S., Y.L.), VA Long Beach Healthcare System, Department of Human Behavior, University of California, Irvine (C.R.), the Department of Health Research and Policy, Stanford University School of Medicine, Stanford (M.-C.S., Y.L.), and the VA San Diego Healthcare System (M.B.S.) and the Departments of Psychiatry and Family Medicine and Public Health, University of California at San Diego (M.B.S.), San Diego - all in California; VA Cooperative Studies Program Clinical Research Pharmacy Coordinating Center, Albuquerque, NM (C.H., A.D.-K.); the Department of Psychiatry, Howard University (T.A.M.), and the Cooperative Studies Program Central Office (G.D.H.), Department of Veterans Affairs, Office of Research and Development (T.G.), Washington, DC; VA Salt Lake City, Salt Lake City (J.R.); VA Northeast Program Evaluation Center, West Haven, and the Departments of Psychiatry and Public Health, Yale School of Medicine, New Haven - both in Connecticut (R.R.); and Providence VA Medical Center and the Department of Psychiatry and Human Behavior, Brown Alpert Medical School, Providence, RI (R.S.).
Elaine R PeskindFrom the Veterans Affairs (VA) Northwest Network Mental Illness Research, Education, and Clinical Center (M.A.R., E.R.P., H.A.H., K.L.H., M.M.) and the Department of Psychiatry and Behavioral Sciences, University of Washington School of Medicine (M.A.R., E.R.P., M.M.), Seattle; VA Cooperative Studies Program Coordinating Center, Palo Alto (B.C., M.-C.S., Y.L.), VA Long Beach Healthcare System, Department of Human Behavior, University of California, Irvine (C.R.), the Department of Health Research and Policy, Stanford University School of Medicine, Stanford (M.-C.S., Y.L.), and the VA San Diego Healthcare System (M.B.S.) and the Departments of Psychiatry and Family Medicine and Public Health, University of California at San Diego (M.B.S.), San Diego - all in California; VA Cooperative Studies Program Clinical Research Pharmacy Coordinating Center, Albuquerque, NM (C.H., A.D.-K.); the Department of Psychiatry, Howard University (T.A.M.), and the Cooperative Studies Program Central Office (G.D.H.), Department of Veterans Affairs, Office of Research and Development (T.G.), Washington, DC; VA Salt Lake City, Salt Lake City (J.R.); VA Northeast Program Evaluation Center, West Haven, and the Departments of Psychiatry and Public Health, Yale School of Medicine, New Haven - both in Connecticut (R.R.); and Providence VA Medical Center and the Department of Psychiatry and Human Behavior, Brown Alpert Medical School, Providence, RI (R.S.).
Bruce ChowFrom the Veterans Affairs (VA) Northwest Network Mental Illness Research, Education, and Clinical Center (M.A.R., E.R.P., H.A.H., K.L.H., M.M.) and the Department of Psychiatry and Behavioral Sciences, University of Washington School of Medicine (M.A.R., E.R.P., M.M.), Seattle; VA Cooperative Studies Program Coordinating Center, Palo Alto (B.C., M.-C.S., Y.L.), VA Long Beach Healthcare System, Department of Human Behavior, University of California, Irvine (C.R.), the Department of Health Research and Policy, Stanford University School of Medicine, Stanford (M.-C.S., Y.L.), and the VA San Diego Healthcare System (M.B.S.) and the Departments of Psychiatry and Family Medicine and Public Health, University of California at San Diego (M.B.S.), San Diego - all in California; VA Cooperative Studies Program Clinical Research Pharmacy Coordinating Center, Albuquerque, NM (C.H., A.D.-K.); the Department of Psychiatry, Howard University (T.A.M.), and the Cooperative Studies Program Central Office (G.D.H.), Department of Veterans Affairs, Office of Research and Development (T.G.), Washington, DC; VA Salt Lake City, Salt Lake City (J.R.); VA Northeast Program Evaluation Center, West Haven, and the Departments of Psychiatry and Public Health, Yale School of Medicine, New Haven - both in Connecticut (R.R.); and Providence VA Medical Center and the Department of Psychiatry and Human Behavior, Brown Alpert Medical School, Providence, RI (R.S.).
Crystal HarrisFrom the Veterans Affairs (VA) Northwest Network Mental Illness Research, Education, and Clinical Center (M.A.R., E.R.P., H.A.H., K.L.H., M.M.) and the Department of Psychiatry and Behavioral Sciences, University of Washington School of Medicine (M.A.R., E.R.P., M.M.), Seattle; VA Cooperative Studies Program Coordinating Center, Palo Alto (B.C., M.-C.S., Y.L.), VA Long Beach Healthcare System, Department of Human Behavior, University of California, Irvine (C.R.), the Department of Health Research and Policy, Stanford University School of Medicine, Stanford (M.-C.S., Y.L.), and the VA San Diego Healthcare System (M.B.S.) and the Departments of Psychiatry and Family Medicine and Public Health, University of California at San Diego (M.B.S.), San Diego - all in California; VA Cooperative Studies Program Clinical Research Pharmacy Coordinating Center, Albuquerque, NM (C.H., A.D.-K.); the Department of Psychiatry, Howard University (T.A.M.), and the Cooperative Studies Program Central Office (G.D.H.), Department of Veterans Affairs, Office of Research and Development (T.G.), Washington, DC; VA Salt Lake City, Salt Lake City (J.R.); VA Northeast Program Evaluation Center, West Haven, and the Departments of Psychiatry and Public Health, Yale School of Medicine, New Haven - both in Connecticut (R.R.); and Providence VA Medical Center and the Department of Psychiatry and Human Behavior, Brown Alpert Medical School, Providence, RI (R.S.).
Anne Davis-KarimFrom the Veterans Affairs (VA) Northwest Network Mental Illness Research, Education, and Clinical Center (M.A.R., E.R.P., H.A.H., K.L.H., M.M.) and the Department of Psychiatry and Behavioral Sciences, University of Washington School of Medicine (M.A.R., E.R.P., M.M.), Seattle; VA Cooperative Studies Program Coordinating Center, Palo Alto (B.C., M.-C.S., Y.L.), VA Long Beach Healthcare System, Department of Human Behavior, University of California, Irvine (C.R.), the Department of Health Research and Policy, Stanford University School of Medicine, Stanford (M.-C.S., Y.L.), and the VA San Diego Healthcare System (M.B.S.) and the Departments of Psychiatry and Family Medicine and Public Health, University of California at San Diego (M.B.S.), San Diego - all in California; VA Cooperative Studies Program Clinical Research Pharmacy Coordinating Center, Albuquerque, NM (C.H., A.D.-K.); the Department of Psychiatry, Howard University (T.A.M.), and the Cooperative Studies Program Central Office (G.D.H.), Department of Veterans Affairs, Office of Research and Development (T.G.), Washington, DC; VA Salt Lake City, Salt Lake City (J.R.); VA Northeast Program Evaluation Center, West Haven, and the Departments of Psychiatry and Public Health, Yale School of Medicine, New Haven - both in Connecticut (R.R.); and Providence VA Medical Center and the Department of Psychiatry and Human Behavior, Brown Alpert Medical School, Providence, RI (R.S.).
Hollie A HolmesFrom the Veterans Affairs (VA) Northwest Network Mental Illness Research, Education, and Clinical Center (M.A.R., E.R.P., H.A.H., K.L.H., M.M.) and the Department of Psychiatry and Behavioral Sciences, University of Washington School of Medicine (M.A.R., E.R.P., M.M.), Seattle; VA Cooperative Studies Program Coordinating Center, Palo Alto (B.C., M.-C.S., Y.L.), VA Long Beach Healthcare System, Department of Human Behavior, University of California, Irvine (C.R.), the Department of Health Research and Policy, Stanford University School of Medicine, Stanford (M.-C.S., Y.L.), and the VA San Diego Healthcare System (M.B.S.) and the Departments of Psychiatry and Family Medicine and Public Health, University of California at San Diego (M.B.S.), San Diego - all in California; VA Cooperative Studies Program Clinical Research Pharmacy Coordinating Center, Albuquerque, NM (C.H., A.D.-K.); the Department of Psychiatry, Howard University (T.A.M.), and the Cooperative Studies Program Central Office (G.D.H.), Department of Veterans Affairs, Office of Research and Development (T.G.), Washington, DC; VA Salt Lake City, Salt Lake City (J.R.); VA Northeast Program Evaluation Center, West Haven, and the Departments of Psychiatry and Public Health, Yale School of Medicine, New Haven - both in Connecticut (R.R.); and Providence VA Medical Center and the Department of Psychiatry and Human Behavior, Brown Alpert Medical School, Providence, RI (R.S.).
Kimberly L HartFrom the Veterans Affairs (VA) Northwest Network Mental Illness Research, Education, and Clinical Center (M.A.R., E.R.P., H.A.H., K.L.H., M.M.) and the Department of Psychiatry and Behavioral Sciences, University of Washington School of Medicine (M.A.R., E.R.P., M.M.), Seattle; VA Cooperative Studies Program Coordinating Center, Palo Alto (B.C., M.-C.S., Y.L.), VA Long Beach Healthcare System, Department of Human Behavior, University of California, Irvine (C.R.), the Department of Health Research and Policy, Stanford University School of Medicine, Stanford (M.-C.S., Y.L.), and the VA San Diego Healthcare System (M.B.S.) and the Departments of Psychiatry and Family Medicine and Public Health, University of California at San Diego (M.B.S.), San Diego - all in California; VA Cooperative Studies Program Clinical Research Pharmacy Coordinating Center, Albuquerque, NM (C.H., A.D.-K.); the Department of Psychiatry, Howard University (T.A.M.), and the Cooperative Studies Program Central Office (G.D.H.), Department of Veterans Affairs, Office of Research and Development (T.G.), Washington, DC; VA Salt Lake City, Salt Lake City (J.R.); VA Northeast Program Evaluation Center, West Haven, and the Departments of Psychiatry and Public Health, Yale School of Medicine, New Haven - both in Connecticut (R.R.); and Providence VA Medical Center and the Department of Psychiatry and Human Behavior, Brown Alpert Medical School, Providence, RI (R.S.).
Miles McFallFrom the Veterans Affairs (VA) Northwest Network Mental Illness Research, Education, and Clinical Center (M.A.R., E.R.P., H.A.H., K.L.H., M.M.) and the Department of Psychiatry and Behavioral Sciences, University of Washington School of Medicine (M.A.R., E.R.P., M.M.), Seattle; VA Cooperative Studies Program Coordinating Center, Palo Alto (B.C., M.-C.S., Y.L.), VA Long Beach Healthcare System, Department of Human Behavior, University of California, Irvine (C.R.), the Department of Health Research and Policy, Stanford University School of Medicine, Stanford (M.-C.S., Y.L.), and the VA San Diego Healthcare System (M.B.S.) and the Departments of Psychiatry and Family Medicine and Public Health, University of California at San Diego (M.B.S.), San Diego - all in California; VA Cooperative Studies Program Clinical Research Pharmacy Coordinating Center, Albuquerque, NM (C.H., A.D.-K.); the Department of Psychiatry, Howard University (T.A.M.), and the Cooperative Studies Program Central Office (G.D.H.), Department of Veterans Affairs, Office of Research and Development (T.G.), Washington, DC; VA Salt Lake City, Salt Lake City (J.R.); VA Northeast Program Evaluation Center, West Haven, and the Departments of Psychiatry and Public Health, Yale School of Medicine, New Haven - both in Connecticut (R.R.); and Providence VA Medical Center and the Department of Psychiatry and Human Behavior, Brown Alpert Medical School, Providence, RI (R.S.).
Thomas A MellmanFrom the Veterans Affairs (VA) Northwest Network Mental Illness Research, Education, and Clinical Center (M.A.R., E.R.P., H.A.H., K.L.H., M.M.) and the Department of Psychiatry and Behavioral Sciences, University of Washington School of Medicine (M.A.R., E.R.P., M.M.), Seattle; VA Cooperative Studies Program Coordinating Center, Palo Alto (B.C., M.-C.S., Y.L.), VA Long Beach Healthcare System, Department of Human Behavior, University of California, Irvine (C.R.), the Department of Health Research and Policy, Stanford University School of Medicine, Stanford (M.-C.S., Y.L.), and the VA San Diego Healthcare System (M.B.S.) and the Departments of Psychiatry and Family Medicine and Public Health, University of California at San Diego (M.B.S.), San Diego - all in California; VA Cooperative Studies Program Clinical Research Pharmacy Coordinating Center, Albuquerque, NM (C.H., A.D.-K.); the Department of Psychiatry, Howard University (T.A.M.), and the Cooperative Studies Program Central Office (G.D.H.), Department of Veterans Affairs, Office of Research and Development (T.G.), Washington, DC; VA Salt Lake City, Salt Lake City (J.R.); VA Northeast Program Evaluation Center, West Haven, and the Departments of Psychiatry and Public Health, Yale School of Medicine, New Haven - both in Connecticut (R.R.); and Providence VA Medical Center and the Department of Psychiatry and Human Behavior, Brown Alpert Medical School, Providence, RI (R.S.).
Christopher ReistFrom the Veterans Affairs (VA) Northwest Network Mental Illness Research, Education, and Clinical Center (M.A.R., E.R.P., H.A.H., K.L.H., M.M.) and the Department of Psychiatry and Behavioral Sciences, University of Washington School of Medicine (M.A.R., E.R.P., M.M.), Seattle; VA Cooperative Studies Program Coordinating Center, Palo Alto (B.C., M.-C.S., Y.L.), VA Long Beach Healthcare System, Department of Human Behavior, University of California, Irvine (C.R.), the Department of Health Research and Policy, Stanford University School of Medicine, Stanford (M.-C.S., Y.L.), and the VA San Diego Healthcare System (M.B.S.) and the Departments of Psychiatry and Family Medicine and Public Health, University of California at San Diego (M.B.S.), San Diego - all in California; VA Cooperative Studies Program Clinical Research Pharmacy Coordinating Center, Albuquerque, NM (C.H., A.D.-K.); the Department of Psychiatry, Howard University (T.A.M.), and the Cooperative Studies Program Central Office (G.D.H.), Department of Veterans Affairs, Office of Research and Development (T.G.), Washington, DC; VA Salt Lake City, Salt Lake City (J.R.); VA Northeast Program Evaluation Center, West Haven, and the Departments of Psychiatry and Public Health, Yale School of Medicine, New Haven - both in Connecticut (R.R.); and Providence VA Medical Center and the Department of Psychiatry and Human Behavior, Brown Alpert Medical School, Providence, RI (R.S.).
Jennifer RomesserFrom the Veterans Affairs (VA) Northwest Network Mental Illness Research, Education, and Clinical Center (M.A.R., E.R.P., H.A.H., K.L.H., M.M.) and the Department of Psychiatry and Behavioral Sciences, University of Washington School of Medicine (M.A.R., E.R.P., M.M.), Seattle; VA Cooperative Studies Program Coordinating Center, Palo Alto (B.C., M.-C.S., Y.L.), VA Long Beach Healthcare System, Department of Human Behavior, University of California, Irvine (C.R.), the Department of Health Research and Policy, Stanford University School of Medicine, Stanford (M.-C.S., Y.L.), and the VA San Diego Healthcare System (M.B.S.) and the Departments of Psychiatry and Family Medicine and Public Health, University of California at San Diego (M.B.S.), San Diego - all in California; VA Cooperative Studies Program Clinical Research Pharmacy Coordinating Center, Albuquerque, NM (C.H., A.D.-K.); the Department of Psychiatry, Howard University (T.A.M.), and the Cooperative Studies Program Central Office (G.D.H.), Department of Veterans Affairs, Office of Research and Development (T.G.), Washington, DC; VA Salt Lake City, Salt Lake City (J.R.); VA Northeast Program Evaluation Center, West Haven, and the Departments of Psychiatry and Public Health, Yale School of Medicine, New Haven - both in Connecticut (R.R.); and Providence VA Medical Center and the Department of Psychiatry and Human Behavior, Brown Alpert Medical School, Providence, RI (R.S.).
Robert RosenheckFrom the Veterans Affairs (VA) Northwest Network Mental Illness Research, Education, and Clinical Center (M.A.R., E.R.P., H.A.H., K.L.H., M.M.) and the Department of Psychiatry and Behavioral Sciences, University of Washington School of Medicine (M.A.R., E.R.P., M.M.), Seattle; VA Cooperative Studies Program Coordinating Center, Palo Alto (B.C., M.-C.S., Y.L.), VA Long Beach Healthcare System, Department of Human Behavior, University of California, Irvine (C.R.), the Department of Health Research and Policy, Stanford University School of Medicine, Stanford (M.-C.S., Y.L.), and the VA San Diego Healthcare System (M.B.S.) and the Departments of Psychiatry and Family Medicine and Public Health, University of California at San Diego (M.B.S.), San Diego - all in California; VA Cooperative Studies Program Clinical Research Pharmacy Coordinating Center, Albuquerque, NM (C.H., A.D.-K.); the Department of Psychiatry, Howard University (T.A.M.), and the Cooperative Studies Program Central Office (G.D.H.), Department of Veterans Affairs, Office of Research and Development (T.G.), Washington, DC; VA Salt Lake City, Salt Lake City (J.R.); VA Northeast Program Evaluation Center, West Haven, and the Departments of Psychiatry and Public Health, Yale School of Medicine, New Haven - both in Connecticut (R.R.); and Providence VA Medical Center and the Department of Psychiatry and Human Behavior, Brown Alpert Medical School, Providence, RI (R.S.).
Mei-Chiung ShihFrom the Veterans Affairs (VA) Northwest Network Mental Illness Research, Education, and Clinical Center (M.A.R., E.R.P., H.A.H., K.L.H., M.M.) and the Department of Psychiatry and Behavioral Sciences, University of Washington School of Medicine (M.A.R., E.R.P., M.M.), Seattle; VA Cooperative Studies Program Coordinating Center, Palo Alto (B.C., M.-C.S., Y.L.), VA Long Beach Healthcare System, Department of Human Behavior, University of California, Irvine (C.R.), the Department of Health Research and Policy, Stanford University School of Medicine, Stanford (M.-C.S., Y.L.), and the VA San Diego Healthcare System (M.B.S.) and the Departments of Psychiatry and Family Medicine and Public Health, University of California at San Diego (M.B.S.), San Diego - all in California; VA Cooperative Studies Program Clinical Research Pharmacy Coordinating Center, Albuquerque, NM (C.H., A.D.-K.); the Department of Psychiatry, Howard University (T.A.M.), and the Cooperative Studies Program Central Office (G.D.H.), Department of Veterans Affairs, Office of Research and Development (T.G.), Washington, DC; VA Salt Lake City, Salt Lake City (J.R.); VA Northeast Program Evaluation Center, West Haven, and the Departments of Psychiatry and Public Health, Yale School of Medicine, New Haven - both in Connecticut (R.R.); and Providence VA Medical Center and the Department of Psychiatry and Human Behavior, Brown Alpert Medical School, Providence, RI (R.S.).
Murray B SteinFrom the Veterans Affairs (VA) Northwest Network Mental Illness Research, Education, and Clinical Center (M.A.R., E.R.P., H.A.H., K.L.H., M.M.) and the Department of Psychiatry and Behavioral Sciences, University of Washington School of Medicine (M.A.R., E.R.P., M.M.), Seattle; VA Cooperative Studies Program Coordinating Center, Palo Alto (B.C., M.-C.S., Y.L.), VA Long Beach Healthcare System, Department of Human Behavior, University of California, Irvine (C.R.), the Department of Health Research and Policy, Stanford University School of Medicine, Stanford (M.-C.S., Y.L.), and the VA San Diego Healthcare System (M.B.S.) and the Departments of Psychiatry and Family Medicine and Public Health, University of California at San Diego (M.B.S.), San Diego - all in California; VA Cooperative Studies Program Clinical Research Pharmacy Coordinating Center, Albuquerque, NM (C.H., A.D.-K.); the Department of Psychiatry, Howard University (T.A.M.), and the Cooperative Studies Program Central Office (G.D.H.), Department of Veterans Affairs, Office of Research and Development (T.G.), Washington, DC; VA Salt Lake City, Salt Lake City (J.R.); VA Northeast Program Evaluation Center, West Haven, and the Departments of Psychiatry and Public Health, Yale School of Medicine, New Haven - both in Connecticut (R.R.); and Providence VA Medical Center and the Department of Psychiatry and Human Behavior, Brown Alpert Medical School, Providence, RI (R.S.).
Robert SwiftFrom the Veterans Affairs (VA) Northwest Network Mental Illness Research, Education, and Clinical Center (M.A.R., E.R.P., H.A.H., K.L.H., M.M.) and the Department of Psychiatry and Behavioral Sciences, University of Washington School of Medicine (M.A.R., E.R.P., M.M.), Seattle; VA Cooperative Studies Program Coordinating Center, Palo Alto (B.C., M.-C.S., Y.L.), VA Long Beach Healthcare System, Department of Human Behavior, University of California, Irvine (C.R.), the Department of Health Research and Policy, Stanford University School of Medicine, Stanford (M.-C.S., Y.L.), and the VA San Diego Healthcare System (M.B.S.) and the Departments of Psychiatry and Family Medicine and Public Health, University of California at San Diego (M.B.S.), San Diego - all in California; VA Cooperative Studies Program Clinical Research Pharmacy Coordinating Center, Albuquerque, NM (C.H., A.D.-K.); the Department of Psychiatry, Howard University (T.A.M.), and the Cooperative Studies Program Central Office (G.D.H.), Department of Veterans Affairs, Office of Research and Development (T.G.), Washington, DC; VA Salt Lake City, Salt Lake City (J.R.); VA Northeast Program Evaluation Center, West Haven, and the Departments of Psychiatry and Public Health, Yale School of Medicine, New Haven - both in Connecticut (R.R.); and Providence VA Medical Center and the Department of Psychiatry and Human Behavior, Brown Alpert Medical School, Providence, RI (R.S.).
Theresa GleasonFrom the Veterans Affairs (VA) Northwest Network Mental Illness Research, Education, and Clinical Center (M.A.R., E.R.P., H.A.H., K.L.H., M.M.) and the Department of Psychiatry and Behavioral Sciences, University of Washington School of Medicine (M.A.R., E.R.P., M.M.), Seattle; VA Cooperative Studies Program Coordinating Center, Palo Alto (B.C., M.-C.S., Y.L.), VA Long Beach Healthcare System, Department of Human Behavior, University of California, Irvine (C.R.), the Department of Health Research and Policy, Stanford University School of Medicine, Stanford (M.-C.S., Y.L.), and the VA San Diego Healthcare System (M.B.S.) and the Departments of Psychiatry and Family Medicine and Public Health, University of California at San Diego (M.B.S.), San Diego - all in California; VA Cooperative Studies Program Clinical Research Pharmacy Coordinating Center, Albuquerque, NM (C.H., A.D.-K.); the Department of Psychiatry, Howard University (T.A.M.), and the Cooperative Studies Program Central Office (G.D.H.), Department of Veterans Affairs, Office of Research and Development (T.G.), Washington, DC; VA Salt Lake City, Salt Lake City (J.R.); VA Northeast Program Evaluation Center, West Haven, and the Departments of Psychiatry and Public Health, Yale School of Medicine, New Haven - both in Connecticut (R.R.); and Providence VA Medical Center and the Department of Psychiatry and Human Behavior, Brown Alpert Medical School, Providence, RI (R.S.).
Ying LuFrom the Veterans Affairs (VA) Northwest Network Mental Illness Research, Education, and Clinical Center (M.A.R., E.R.P., H.A.H., K.L.H., M.M.) and the Department of Psychiatry and Behavioral Sciences, University of Washington School of Medicine (M.A.R., E.R.P., M.M.), Seattle; VA Cooperative Studies Program Coordinating Center, Palo Alto (B.C., M.-C.S., Y.L.), VA Long Beach Healthcare System, Department of Human Behavior, University of California, Irvine (C.R.), the Department of Health Research and Policy, Stanford University School of Medicine, Stanford (M.-C.S., Y.L.), and the VA San Diego Healthcare System (M.B.S.) and the Departments of Psychiatry and Family Medicine and Public Health, University of California at San Diego (M.B.S.), San Diego - all in California; VA Cooperative Studies Program Clinical Research Pharmacy Coordinating Center, Albuquerque, NM (C.H., A.D.-K.); the Department of Psychiatry, Howard University (T.A.M.), and the Cooperative Studies Program Central Office (G.D.H.), Department of Veterans Affairs, Office of Research and Development (T.G.), Washington, DC; VA Salt Lake City, Salt Lake City (J.R.); VA Northeast Program Evaluation Center, West Haven, and the Departments of Psychiatry and Public Health, Yale School of Medicine, New Haven - both in Connecticut (R.R.); and Providence VA Medical Center and the Department of Psychiatry and Human Behavior, Brown Alpert Medical School, Providence, RI (R.S.).
Grant D HuangFrom the Veterans Affairs (VA) Northwest Network Mental Illness Research, Education, and Clinical Center (M.A.R., E.R.P., H.A.H., K.L.H., M.M.) and the Department of Psychiatry and Behavioral Sciences, University of Washington School of Medicine (M.A.R., E.R.P., M.M.), Seattle; VA Cooperative Studies Program Coordinating Center, Palo Alto (B.C., M.-C.S., Y.L.), VA Long Beach Healthcare System, Department of Human Behavior, University of California, Irvine (C.R.), the Department of Health Research and Policy, Stanford University School of Medicine, Stanford (M.-C.S., Y.L.), and the VA San Diego Healthcare System (M.B.S.) and the Departments of Psychiatry and Family Medicine and Public Health, University of California at San Diego (M.B.S.), San Diego - all in California; VA Cooperative Studies Program Clinical Research Pharmacy Coordinating Center, Albuquerque, NM (C.H., A.D.-K.); the Department of Psychiatry, Howard University (T.A.M.), and the Cooperative Studies Program Central Office (G.D.H.), Department of Veterans Affairs, Office of Research and Development (T.G.), Washington, DC; VA Salt Lake City, Salt Lake City (J.R.); VA Northeast Program Evaluation Center, West Haven, and the Departments of Psychiatry and Public Health, Yale School of Medicine, New Haven - both in Connecticut (R.R.); and Providence VA Medical Center and the Department of Psychiatry and Human Behavior, Brown Alpert Medical School, Providence, RI (R.S.).
VA Northwest Network · USGeriatric Research Education and Clinical Center · USProgram Support Center · USHoward University · USProvidence VA Medical Center · USStanford University · USUniversity of California, San Diego · USUniversity of Washington · USVA Long Beach Healthcare System · USVA Salt Lake City Healthcare System · USYale University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundIn randomized trials, prazosin, an α

methodsWe recruited veterans from 13 Department of Veterans Affairs medical centers who had chronic PTSD and reported frequent nightmares. Participants were randomly assigned to receive prazosin or placebo for 26 weeks; the drug or placebo was administered in escalating divided doses over the course of 5 weeks to a daily maximum of 20 mg in men and 12 mg in women. After week 10, participants continued to receive prazosin or placebo in a double-blind fashion for an additional 16 weeks. The three primary outcome measures were the change in score from baseline to 10 weeks on the Clinician-Administered PTSD Scale (CAPS) item B2 ("recurrent distressing dreams"; scores range from 0 to 8, with higher scores indicating more frequent and more distressing dreams); the change in score from baseline to 10 weeks on the Pittsburgh Sleep Quality Index (PSQI; scores range from 0 to 21, with higher scores indicating worse sleep quality); and the Clinical Global Impression of Change (CGIC) score at 10 weeks (scores range from 1 to 7, with lower scores indicating greater improvement and a score of 4 indicating no change).

resultsA total of 304 participants underwent randomization; 152 were assigned to prazosin, and 152 to placebo. At 10 weeks, there were no significant differences between the prazosin group and the placebo group in the mean change from baseline in the CAPS item B2 score (between-group difference, 0.2; 95% confidence interval [CI], -0.3 to 0.8; P=0.38), in the mean change in PSQI score (between-group difference, 0.1; 95% CI, -0.9 to 1.1; P=0.80), or in the CGIC score (between-group difference, 0; 95% CI, -0.3 to 0.3; P=0.96). There were no significant differences in these measures at 26 weeks (a secondary outcome) or in other secondary outcomes. At 10 weeks, the mean difference between the prazosin group and the placebo group in the change from baseline in supine systolic blood pressure was a decrease of 6.7 mm Hg. The adverse event of new or worsening suicidal ideation occurred in 8% of the participants assigned to prazosin versus 15% of those assigned to placebo.

conclusionsIn this trial involving military veterans who had chronic PTSD, prazosin did not alleviate distressing dreams or improve sleep quality. (Funded by the Department of Veterans Affairs Cooperative Studies Program; PACT ClinicalTrials.gov number, NCT00532493 .).

Indexed as

VeteransAdrenergic alpha-1 Receptor AntagonistsAdultCombined Modality TherapyDose-Response Relationship, DrugDouble-Blind MethodDreamsFemaleHospitals, VeteransHumansMaleMiddle AgedPrazosinPsychiatric Status Rating ScalesPsychotherapySleepAdrenergic alpha-1 Receptor AntagonistsPrazosin

Identifiers

PMID29414272
OpenAlexW2789959403

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.