ArticleInternational journal for parasitology. Drugs and drug resistance2018
The optimal timing of post-treatment sampling for the assessment of anthelminthic drug efficacy against Ascaris infections in humans.
Article in International journal for parasitology. Drugs and drug resistance, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
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Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Efficacy and safety of co-administered ivermectin plus albendazole for treating soil-transmitted helminths: A systematic review, meta-analysis and individual patient data analysis.PLoS neglected tropical diseases · 2018Pooled it
- Thereaputic efficacy of single dose Albendazole against Ascaris lumbricoides, prevalence of re-infection, and its associated factors among school children at Northwest Ethiopia: an open-label trial study.BMC infectious diseases · 2026Trial
- Egg excretion patterns of soil-transmitted helminth infections in humans following albendazole-ivermectin and albendazole treatment.PLoS neglected tropical diseases · 2024Trial
- Individual responses to a single oral dose of albendazole indicate reduced efficacy against soil-transmitted helminths in an area with high drug pressure.PLoS neglected tropical diseases · 2021Trial
- Therapeutic efficacy of albendazole against soil-transmitted helminthiasis in children measured by five diagnostic methods.PLoS neglected tropical diseases · 2019Trial
- Molecular epidemiology of Ascaris lumbricoides following multiple rounds of community-wide treatment.Nature communications · 2025Article
- Factors contributing to helminth prevalence after repeated mass administration of medicines in Anambra State, Nigeria.Scientific reports · 2025Article
- Human intestinal nematode infections in Sri Lanka: A scoping review.PLoS neglected tropical diseases · 2024Article
- Epidemiology and field efficacy of anthelmintic drugs associated with gastrointestinal nematodes of sheep in Nejo district, Oromia, Ethiopia.Scientific reports · 2024Article
- Spatial heterogeneity in mass drug administration from a longitudinal epidemiological study assessing transmission interruption of soil transmitted helminths in the Wolaita zone of southern Ethiopia (Geshiyaro Project).PLoS neglected tropical diseases · 2024Article
- Gut bacteriome and metabolome of Ascaris lumbricoides in patients.Scientific reports · 2022Article
- Egg excretion indicators for the measurement of soil-transmitted helminth response to treatment.PLoS neglected tropical diseases · 2022Article
- Resistance to single dose albendazole and reinfection with intestinal helminths among children ages 2 to 11 years from the Peruvian Amazon region: a study protocol.BMC infectious diseases · 2022Article
- Efficacy of triple dose albendazole treatment for soil-transmitted helminth infections.PloS one · 2022Article
- Improving anthelmintic treatment for schistosomiasis and soil-transmitted helminthiases through sharing and reuse of individual participant data.Wellcome open research · 2022Article
- Helminthic Infection in the Background of Active Pulmonary Tuberculosis: An Underreported Co-infection.Cureus · 2021Article
- Susceptible trichostrongyloid species mask presence of benzimidazole-resistant Haemonchus contortus in cattle.Parasites & vectors · 2021Article
- Article
- Anthelmintic efficacy against gastrointestinal nematodes in goats raised under mountain farming conditions in northern Italy.BMC veterinary research · 2019Article
- Epidemiology of strongyle nematode infections and first report of benzimidazole resistance in Haemonchus contortus in goats in South Darfur State, Sudan.BMC veterinary research · 2019Article
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Abstract
The egg reduction rate (ERR) is the current standard mean to assess the efficacy of drugs against human soil-transmitted helminths (STHs; Ascaris lumbricoides, Trichuris trichiura and hookworm). Although the timing of post-treatment sampling is pivotal for a readily interpretation of drug efficacy, there is lack empirical data that allows recommending the optimal time point for a follow-up egg counting. In the present study, we re-analyzed both the kinetics of worm expulsion and egg output for Ascaris lumbricoides following a single oral dose of albendazole in a series of studies previously conducted in Kenyan communities. The results indicate that it takes up to 10 days post-treatment before the expulsion of both adult male and female Ascaris worms is completed, approximately 20% of the worms being expelled between day 7 and 10 post-treatment. The sequential analysis of the egg out put, indicated a poor ERR (89.4%) at day 7 post-treatment, but a 100% ERR at day 14 and 21 post-treatment. Based on our findings we recommend to wait at least 14 days after an albendazole treatment before conducting the follow-up egg count. Any sampling before this time point may result in biased ERR estimates, due the release of residual eggs from moribund or degenerating worms.
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