ReviewCurrent opinion in neurobiology2018
A disinhibitory circuit motif and flexible information routing in the brain.
Review in Current opinion in neurobiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
49 citing papers in PubMed.
- Article
- Disinhibitory signaling enables flexible coding of top-down information in cortical networks.PLoS biology · 2026Article
- Testing circuit-level theories of consciousness in humans.Trends in cognitive sciences · 2026Review
- Prefrontal cortex interneurons and their contributions to attention, working memory, and adaptive behavior.Progress in neurobiology · 2026Review
- Disinhibition of a recurrent attractor gates a persistent goal signal for navigation.bioRxiv : the preprint server for biology · 2025Article
- Functional thalamocortical innervation of VIP- and SST-expressing GABAergic interneurons in mouse barrel cortex.iScience · 2025Article
- Untangling stability and gain modulation in cortical circuits with multiple interneuron classes.eLife · 2025Article
- Biological detail and graph structure in network neuroscience.Frontiers in network physiology · 2025Review
- Compartmentalized pooling generates orientation selectivity in wide-field amacrine cells.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Simultaneous interneuron labeling reveals cell type-specific, population-level interactions in cortex.iScience · 2024Article
- Top-down modulation in canonical cortical circuits with short-term plasticity.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Simultaneous interneuron labeling reveals population-level interactions among parvalbumin, somatostatin, and pyramidal neurons in cortex.bioRxiv : the preprint server for biology · 2024Article
- Cellular mechanisms of cooperative context-sensitive predictive inference.Current research in neurobiology · 2024Review
- γ And β Band Oscillation in Working Memory Given Sequential or Concurrent Multiple Items: A Spiking Network Model.eNeuro · 2023Article
- Training biologically plausible recurrent neural networks on cognitive tasks with long-term dependencies.bioRxiv : the preprint server for biology · 2023Article
- Inter-areal transmission of multiple neural signals through frequency-division-multiplexing communication.Cognitive neurodynamics · 2023Article
- Article
- Flexible control of representational dynamics in a disinhibition-based model of decision-making.eLife · 2023Article
- Arousal and Locomotion Differently Modulate Activity of Somatostatin Neurons across Cortex.eNeuro · 2023Article
- Stability and learning in excitatory synapses by nonlinear inhibitory plasticity.PLoS computational biology · 2022Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
In the mammalian neocortex, an area typically receives inputs from, and projects to, dozens of other areas. Mechanisms are needed to flexibly route information to the right place at the right time, which we term 'pathway gating'. For instance, a region in your brain that receives signals from both visual and auditory pathways may want to 'gate in' the visual pathway while 'gating out' the auditory pathway when you try to read a book surrounded by people in a noisy café. In this review, we marshall experimental and computational evidence in support of a circuit mechanism for flexible pathway gating realized by a disinhibitory motif. Moreover, recent work shows an increasing preponderance of this disinhibitory motif from sensory areas to association areas of the mammalian cortex. Pathway input gating is briefly compared with alternative or complementary gating mechanisms. Predictions and open questions for future research on this puzzle about the complex brain system will be discussed.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.