ArticlePsychoneuroendocrinology2018
Effects of testosterone dose on spatial memory among castrated adult male rats.
Article in Psychoneuroendocrinology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Disturbed Spatial Learning and Hippocampal Molecular and Histological Alterations in Middle-Aged Rats with a History of Polycystic Ovary Syndrome.International journal of endocrinology and metabolism · 2027Article
- Therapeutic potential of nasal kisspeptin-54 for reducing α-synuclein accumulation and restoring hippocampal synaptic plasticity in a 6-hydroxydopamine-induced rat model of Parkinson's disease.Turkish journal of medical sciences · 2026Article
- Effects of Testosterone and Its Major Metabolites upon Different Stages of Neuron Survival in the Dentate Gyrus of Male Rats.Biomolecules · 2025Article
- Local synthesis and function of neuro-estrogen and neuro-androgen: impact on the hippocampus-related cognition and neuronal plasticity.Frontiers in cellular neuroscience · 2025Review
- The effects of peripheral hormone responses to exercise on adult hippocampal neurogenesis.Frontiers in endocrinology · 2023Review
- Hippocampal synaptic dysfunction and spatial memory impairment in omeprazole-treated rats.Metabolic brain disease · 2022Article
- Effects of Long-Acting Testosterone Undecanoate on Behavioral Parameters and Na + , KNeurochemical research · 2021Article
- Article
- Regulation of risky decision making by gonadal hormones in males and females.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2021Article
- Dose-dependent effects of testosterone on spatial learning strategies and brain-derived neurotrophic factor in male rats.Psychoneuroendocrinology · 2020Article
- Article
- Testosterone enhances mitochondrial complex V function in the substantia nigra of aged male rats.Aging · 2020Article
- Testosterone replacement causes dose-dependent improvements in spatial memory among aged male rats.Psychoneuroendocrinology · 2020Article
- Testosterone and Adult Neurogenesis.Biomolecules · 2020Review
- Rapid Estrogenic and Androgenic Neurosteroids Effects in the Induction of Long-Term Synaptic Changes: Implication for Early Memory Formation.Frontiers in neuroscience · 2020Review
- Activation of androgen receptors protects intact male mice from memory impairments caused by aromatase inhibition.Hormones and behavior · 2019Article
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6 authors.
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Abstract
Previous research on the activational effects of testosterone on spatial memory has produced mixed results, possibly because such effects are dose-dependent. We tested a wide range of testosterone doses using two spatial memory tasks: a working-reference memory version of the radial-arm maze (RAM) and an object location memory task (OLMT). Adult male Sprague-Dawley rats were castrated or sham-castrated and given daily injections of drug vehicle (Oil Sham and Oil GDX) or one of four doses of testosterone propionate (0.125, 0.250, 0.500, and 1.000 mg T) beginning seven days before the first day of behavioral tests and continuing throughout testing. For the RAM, four arms of the maze were consistently baited on each day of testing. Testosterone had a significant effect on working memory on the RAM, with the Oil Sham, 0.125 mg T, and 0.500 mg T groups performing better than the Oil GDX group. In contrast, there was no significant effect of testosterone on spatial reference memory on the RAM. For the OLMT, we tested long-term memory using a 2 h inter-trial interval between first exposure to two identical objects and re-exposure after one object had been moved. Only the 0.125 and 0.500 mg T groups showed a significant increase in exploration of the moved object during the testing trials, indicating better memory than all other groups. Testosterone replacement restored spatial memory among castrated male rats on both behavioral tasks, but there was a complex dose-response relationship; therefore, the therapeutic value of testosterone is likely sensitive to dose.
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