Evidence map›Paper›PMID 29413969›Full record

ReviewCurrent opinion in cell biology2017

Tracking the origin, development, and differentiation of hematopoietic stem cells.

Priyanka R Dharampuriya, Giorgia Scapin, Colline Wong, K John Wagner, Jennifer L Cillis, Dhvanit I Shah

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Current opinion in cell biology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Multi-lineage Differentiation from Hematopoietic Stem Cells.Advances in experimental medicine and biology · 2023
    Review
  6. Molecular regulation of hematopoietic stem cell quiescence.Cellular and molecular life sciences : CMLS · 2022
    Review
  7. Article
  8. Review
  9. Observational
  10. Optimal experimental design for mathematical models of haematopoiesis.Journal of the Royal Society, Interface · 2021
    Article
  11. Article
  12. Article
  13. Analysis of Hematopoietic Stem Progenitor Cell Metabolism.Journal of visualized experiments : JoVE · 2019
    Article
  14. Article
  15. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Priyanka R DharampuriyaDivision of Hematology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA; Harvard Stem Cell Institute, Cambridge, MA 02138, USA.
Giorgia ScapinDivision of Hematology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA; Harvard Stem Cell Institute, Cambridge, MA 02138, USA; Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, MA 02138, USA.
Colline WongDivision of Hematology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA; Harvard Stem Cell Institute, Cambridge, MA 02138, USA; Boston College, Chestnut Hill, MA 02467, USA.
K John WagnerDivision of Hematology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA; Harvard Stem Cell Institute, Cambridge, MA 02138, USA; Boston College, Chestnut Hill, MA 02467, USA.
Jennifer L CillisDivision of Hematology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA; Harvard Stem Cell Institute, Cambridge, MA 02138, USA; Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, MA 02138, USA.
Dhvanit I ShahDivision of Hematology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA; Harvard Stem Cell Institute, Cambridge, MA 02138, USA; Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, MA 02138, USA; Dana-Farber/Harvard Cancer Center, Boston, MA 02115, USA. Electronic address: dshah@research.bwh.harvard.edu.

Funding

Biomechanical Stimulation of Hemogenic Endothelial Cells to Develop Clinical-Grade Hematopoietic Stem CellsR01HL131645 · NHLBI · RESEARCH INST NATIONWIDE CHILDREN'S HOSP · PI SHAH, DHVANIT INDRAVADAN · 2016 to 2019
$1.6M
NHLBI NIH HHS R01 HL131645
6 · The paper itself

Abstract

purpose of reviewThe hierarchical nature of the hematopoietic system provides an ideal model system to illustrate the features of lineage tracing. We have outlined the utility of lineage tracing methods in establishing the origin and development of hematopoietic cells. RECENT

findingsMethods such as CRISPR/Cas9, Polylox barcoding, and single-cell RNA-sequencing have improved our understanding of hematopoiesis. SUMMARY: This review chronicles the fate of the hematopoietic cells emerging from the mesoderm that subsequently develops into the adult blood lineages. Specifically, we explain classic techniques utilized in lineage tracing for the hematopoietic system, as well as novel state-of-the-art methods to elucidate clonal hematopoiesis and cell fate mapping at a single-cell level.

Indexed as

Cell DifferentiationHematopoiesisHematopoietic Stem CellsHumans

Identifiers

PMID29413969
PMCPMC5821519

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.