ArticleRedox biology2018
In situ generation, metabolism and immunomodulatory signaling actions of nitro-conjugated linoleic acid in a murine model of inflammation.
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In one paragraph
Article in Redox biology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
46citing papers in PubMed, 1 pooled it
6.1field-weighted citation impact, top 3% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
46 citing papers in PubMed, 1 synthesis or guideline pooled it, 70 citations in OpenAlex.
- The effects of conjugated linoleic acid supplementation on inflammatory cytokines and adipokines in adults: A GRADE-assessed systematic review and dose-response meta-analysis.Frontiers in immunology · 2023Pooled it
- Ultrasound targeted fatty acid nitroalkene-containing lipid nanoparticles attenuate inflammation and reverse myocardial fibrosis.Theranostics · 2026Article
- Study on the Enrichment Effect ofMicroorganisms · 2025Article
- Nitrated fatty acids protect against acute kidney injury in sickle cell disease.Blood advances · 2025Article
- Unraveling the nexus: Genomic instability and metabolism in cancer.Cell reports · 2025Review
- The Octadecanoids: Synthesis and Bioactivity of 18-Carbon Oxygenated Fatty Acids in Mammals, Bacteria, and Fungi.Chemical reviews · 2025Review
- Development of nitroalkene-based inhibitors to target STING-dependent inflammation.Redox biology · 2024Article
- The chemical biology of dinitrogen trioxide.Redox biochemistry and chemistry · 2024Article
- Integration of clinical phenoms and metabolomics facilitates precision medicine for lung cancer.Cell biology and toxicology · 2024Article
- Digestive interaction between dietary nitrite and dairy products generates novel nitrated linolenic acid products.Food chemistry · 2024Article
- Effect of nitro-conjugated linoleic acid on the inflammatory response of murine macrophages activated with lipopolysaccharide derived from Prevotella intermedia.Inflammopharmacology · 2024Article
- Analysis of Phosphatidylinositol Modifications by Reactive Nitrogen Species Using LC-MS: Coming to Grips with Their Nitroxidative Susceptibility.Journal of the American Society for Mass Spectrometry · 2023Article
- Protective Effect of NOCells · 2023Article
- Nitro-oleic acid regulates T cell activation through post-translational modification of calcineurin.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Induction of glutathione biosynthesis by glycine-based treatment mitigates atherosclerosis.Redox biology · 2022Article
- Post-Translational Modifications of STING: A Potential Therapeutic Target.Frontiers in immunology · 2022Review
- Lipid nitroalkene nanoparticles for the focal treatment of ischemia reperfusion.Nanotheranostics · 2022Article
- Nitro-fatty acids decrease type I interferons and monocyte chemoattractant protein 1 in ex vivo models of inflammatory arthritis.BMC immunology · 2021Article
- Review
- Chemoproteomic profiling reveals cellular targets of nitro-fatty acids.Redox biology · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
15 authors at 3 institutions in 3 countries.
Luis VillacortaDepartment of Internal Medicine, Frankel Cardiovascular Center, University of Michigan Medical Center, Ann Arbor, MI, USA. Electronic address: luisvill@umich.edu.
Lucia MinarrietaCátedra de Inmunología, Facultad de Química y Ciencias, Universidad de la República, Montevideo, Uruguay; Institute of Infection Immunology, TWINCORE, Hannover, Germany.
Sonia R SalvatoreDepartment of Pharmacology and Chemical Biology, University of Pittsburgh, Pittsburgh, PA, USA.
Nicholas K KhooDepartment of Pharmacology and Chemical Biology, University of Pittsburgh, Pittsburgh, PA, USA.
Oren RomDepartment of Internal Medicine, Frankel Cardiovascular Center, University of Michigan Medical Center, Ann Arbor, MI, USA.
Zhen GaoDepartment of Internal Medicine, Frankel Cardiovascular Center, University of Michigan Medical Center, Ann Arbor, MI, USA.
Rebecca C BermanDepartment of Internal Medicine, Frankel Cardiovascular Center, University of Michigan Medical Center, Ann Arbor, MI, USA.
Soma JobbagyDepartment of Pharmacology and Chemical Biology, University of Pittsburgh, Pittsburgh, PA, USA.
Lihua LiDepartment of Pharmacology and Chemical Biology, University of Pittsburgh, Pittsburgh, PA, USA.
Steven R WoodcockDepartment of Pharmacology and Chemical Biology, University of Pittsburgh, Pittsburgh, PA, USA.
Y Eugene ChenDepartment of Cardiac Surgery, Frankel Cardiovascular Center, University of Michigan Medical Center, Ann Arbor, MI, USA.
Bruce A FreemanDepartment of Pharmacology and Chemical Biology, University of Pittsburgh, Pittsburgh, PA, USA.
Ana M FerreiraCátedra de Inmunología, Facultad de Química y Ciencias, Universidad de la República, Montevideo, Uruguay.
Francisco J SchopferDepartment of Pharmacology and Chemical Biology, University of Pittsburgh, Pittsburgh, PA, USA.
Dario A VitturiDepartment of Pharmacology and Chemical Biology, University of Pittsburgh, Pittsburgh, PA, USA. Electronic address: dav28@pitt.edu.
University of Pittsburgh · USUniversity of Michigan–Ann Arbor · USUniversidad de la República · UY
Funding
Vascular Subphenotypes of Lung DiseaseP01HL103455 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI MORRIS, ALISON · 2011 to 2020
$26.1MThe Role of PPAR-gamma in Vascular Lesion FormationR01HL068878 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI CHEN, YUQING EUGENE · 2002 to 2019
$7.6MRedox Transduction of Nitric Oxide SignalingR37HL058115 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI FREEMAN, BRUCE ALAN · 2008 to 2017
$5.2MFormation and metabolism of nitrated fatty acidsR01GM125944 · NIGMS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI SCHOPFER, FRANCISCO JOSE · 2018 to 2025
$3.4MAnti-Inflammatory Lipid Mediators in AsthmaR01HL132550 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI FREEMAN, BRUCE ALAN, HOLGUIN, FERNANDO · 2016 to 2019
$2.9MConjugated linoleic acid nitration in vascular inflammation and atherosclerosisR01HL123333 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI VILLACORTA, LUIS · 2015 to 2019
$2.0MFormation of Omega 3-Derived Electrophiles During InflammationR01AT006822 · NCCIH · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI SCHOPFER, FRANCISCO JOSE · 2011 to 2015
$1.8MProtection against sickle cell disease nephropathy by nitrated fatty acidsK01HL133331 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI VITTURI, DARIO A · 2016 to 2021
$848kNCCIH NIH HHS R01 AT006822NHLBI NIH HHS K01 HL133331NHLBI NIH HHS P01 HL103455NHLBI NIH HHS R01 HL068878NHLBI NIH HHS R01 HL123333NHLBI NIH HHS R01 HL132550NHLBI NIH HHS R37 HL058115NIGMS NIH HHS R01 GM125944
Abstract
Conjugated linoleic acid (CLA) is a prime substrate for intra-gastric nitration giving rise to the formation of nitro-conjugated linoleic acid (NO
Indexed as
AnimalsDisease Models, AnimalHumansImmunoconjugatesInflammationLinoleic Acids, ConjugatedMiceNF-kappa BNitric OxideSignal TransductionImmunoconjugatesLinoleic Acids, ConjugatedNF-kappa BNitric OxideElectrophileInflammationMacrophageNF-κBNitrationNitro-fatty acidNrf2
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.