Evidence map›Paper›PMID 29413963›Full record

ArticleRedox biology2018

Renal protective effect of polysulfide in cisplatin-induced nephrotoxicity.

Xu Cao, Xiaowei Nie, Siping Xiong, Lei Cao, Zhiyuan Wu, Philip K Moore, Jin-Song Bian

Open access · goldAbstract read
In one paragraph

Article in Redox biology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed, 1 pooled it
5.5field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 1 synthesis or guideline pooled it, 70 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Frontiers in pharmacology · 2023
    Article
  11. Article
  12. Article
  13. Article
  14. Review
  15. Endogenous SORedox biology · 2021
    Article
  16. Hydrogen Sulfide and the Kidney.Advances in experimental medicine and biology · 2021
    Article
  17. Review
  18. Protective Role of Nrf2 in Renal Disease.Antioxidants (Basel, Switzerland) · 2020
    Review
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 2 countries.

Xu CaoDepartment of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117600, Singapore.
Xiaowei NieCenter of Clinical Research, Wuxi People's Hospital of Nanjing Medical University, Wuxi, Jiangsu 214023, PR China.
Siping XiongDepartment of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117600, Singapore.
Lei CaoDepartment of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117600, Singapore.
Zhiyuan WuDepartment of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117600, Singapore; Life Science Institute, National University of Singapore, Singapore.
Philip K MooreDepartment of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117600, Singapore; Life Science Institute, National University of Singapore, Singapore.
Jin-Song BianDepartment of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117600, Singapore. Electronic address: phcbjs@nus.edu.sg.
National University of Singapore · SGNanjing Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cisplatin is a major chemotherapeutic drug for solid tumors whereas it may lead to severe nephrotoxicity. Despite decades of efforts, effective therapies remain largely lacking for this disease. In the current research, we investigated the therapeutic effect of hydrogen polysulfide, a novel hydrogen sulfide (H

Indexed as

AnimalsCarcinoma, Non-Small-Cell LungCell LineCisplatinGene Expression Regulation, NeoplasticHumansHydrogen SulfideKidneyNADPH OxidasesRatsReactive Oxygen SpeciesRenal InsufficiencySulfidesSus scrofaCisplatinHydrogen SulfideNADPH OxidasespolysulfideReactive Oxygen SpeciesSulfidesCisplatin nephrotoxicityHydrogen sulfideNADPH oxidaseNuclear factor erythroid 2-related factor 2PolysulfideReactive oxygen species

Identifiers

PMID29413963
PMCPMC5881418
OpenAlexW2792077511

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.