Trial reportEarly human development2018
Association between cognition and the retinal microvasculature in 11-year old children born preterm or at term.
Trial report in Early human development, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 2 syntheses or guidelines pooled it, 25 citations in OpenAlex.
- Look into my eyes: What can eye-based measures tell us about the relationship between physical activity and cognitive performance?Journal of sport and health science · 2023Pooled it
- Intelligence Quotient (IQ) in school-aged preterm infants: A systematic review.Frontiers in psychology · 2023Pooled it
- Retinal Microvasculature and Emotional, Behavioral, and Cognitive Outcomes at School Age.Journal of the American Heart Association · 2026Article
- Retinal biomarkers in schizophrenia spectrum disorders: evidence and implications for the neurodevelopmental and neurodegenerative models.Frontiers in medicine · 2025Review
- Changes of the peripapillary vascular parameters in premature infants without retinopathy of prematurity using U-net segmentation.International journal of ophthalmology · 2024Article
- Perfused boundary region as biomarker for endothelial integrity in former preterms in adolescence.Pediatric research · 2023Article
- Optic disc and retinal vascular features in first 6 years of Chinese children.Frontiers in pediatrics · 2023Article
- Retinal Microvasculature in Schizophrenia.Eye and brain · 2021Article
- Denser Retinal Microvascular Network Is Inversely Associated With Behavioral Outcomes and Sustained Attention in Children.Frontiers in neurology · 2021Article
- Retinal and Renal Microvasculature in Relation to Central Hemodynamics in 11-Year-Old Children Born Preterm or At Term.Journal of the American Heart Association · 2020Article
- Association of Retinal Microvascular Characteristics With Short-term Memory Performance in Children Aged 4 to 5 Years.JAMA network open · 2020Article
- Article
- Central arterial stiffness and retinal vessel calibers: the Atherosclerosis Risk in Communities Study-Neurocognitive Study.Journal of hypertension · 2020Article
- Altered Intrinsic Brain Activities in Patients with Diabetic Retinopathy Using Amplitude of Low-frequency Fluctuation: A Resting-state fMRI Study.Diabetes, metabolic syndrome and obesity : targets and therapy · 2020Article
- Retinal Microvasculature in Relation to Central Hemodynamics in a Flemish Population.Hypertension (Dallas, Tex. : 1979) · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundRetinal microvessels can be visualized non-invasively and mirror the status of the cerebral microvasculature.
aimsTo investigate whether in young children born prematurely or at term cognitive performance is related to retinal microvascular traits. STUDY DESIGN, SUBJECTS: In 93 prematurely born infants (birth weight < 1000 g) and 87 controls born at term, we measured head circumference (HC) and determined intelligence quotient (IQ) by combining matrix reasoning and spatial span (Wechsler Non-Verbal test, Dutch version) and post-processed retinal photographs using Singapore I Vessel Assessment software (version 3.6). OUTCOME MEASURES,
resultsCompared with controls, cases had smaller HC (51.7 vs 53.4 cm; p < 0.001), lower IQ (93.9 vs 109.2; p < 0.001), smaller retinal arteriolar (CRAE; 162.7 vs 174.0 μm; p < 0.001) and venular (CRVE; 234.9 vs 242.8 μm; p = 0.003) diameters and CRAE/CRVE ratio (0.69 vs 0.72; p = 0.001). A 1-SD decrease in CRAE was associated with smaller HC (-0.53 cm; p < 0.001) and lower total IQ (-3.74; p < 0.001), matrix reasoning (-1.77; p = 0.004) and spatial span (-2.03; p = 0.002). These associations persisted after adjustment for sex and age and risk factors for cognitive impairment, including blood pressure, body mass index and parental educational attainment.
conclusionsHC, total IQ, matrix reasoning and spatial span decrease with smaller retinal arteriolar diameter. Our findings suggest that maldevelopment of the cerebral microcirculation, as mirrored by the retinal microvasculature, has lasting effects on the growth of the brain and cognitive performance of prematurely born children.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.