Evidence map›Paper›PMID 29413653›Full record

ReviewSurgical pathology clinics2018

Lobular Carcinoma In Situ.

Hannah Y Wen, Edi Brogi

Registry-linked trialOpen access · greenAbstract readReview
In one paragraph

Review in Surgical pathology clinics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06133465 (Pure Florid and Pleomorphic Lobular Carcinoma in Situ of the Breast), which is not on this map. Cited by 37 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
37citing papers in PubMed, 1 pooled it
3.5field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06133465 completednot on this mapstarted 2023, after this paper: background citation

Pure Florid and Pleomorphic Lobular Carcinoma in Situ of the Breast: Towards an Increasingly Uniform Management. A Multicenter Observational Retrospective Study.

TypeobservationalSponsorIstituto Oncologico Veneto IRCCSRan2023 to 2025Enrolled1,063ConditionsPleomorphic Lobular Breast Carcinoma in Situ, Breast Florid Lobular Carcinoma in SituArmsSurgical wide local excision, Cavity shaving, Excision margin surgical clearance, Adjuvant Radiotherapy, Adjuvant Hormone Therapy
3 · Its place in the literature

Who cites it

37 citing papers in PubMed, 1 synthesis or guideline pooled it, 98 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Clinical Outcomes of Lobular CarcinomaJournal of breast cancer · 2026
    Article
  4. Article
  5. Review
  6. Article
  7. Breast Cancer Polygenic Risk Score Associated with Outcomes after In Situ Breast Disease.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2025
    Article
  8. Article
  9. Review
  10. Review
  11. Article
  12. Review
  13. Article
  14. Article
  15. Article
  16. Review
  17. Review
  18. Review
  19. Results of a worldwide survey on the currently used histopathological diagnostic criteria for invasive lobular breast cancer.Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc · 2022
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Hannah Y WenDepartment of Pathology, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, USA. Electronic address: weny@mskcc.org.
Edi BrogiDepartment of Pathology, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, USA.
Memorial Sloan Kettering Cancer Center · US

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Nicholas D Socci · 1985 to 2026
$347.4M
NCI NIH HHS P30 CA008748
6 · The paper itself

Abstract

Lobular carcinoma in situ (LCIS) is a risk factor and a nonobligate precursor of breast carcinoma. The relative risk of invasive carcinoma after classic LCIS diagnosis is approximately 9 to 10 times that of the general population. Classic LCIS diagnosed on core biopsy with concordant imaging and pathologic findings does not mandate surgical excision, and margin status is not reported. The identification of variant LCIS in a needle core biopsy specimen mandates surgical excision, regardless of radiologic-pathologic concordance. The presence of variant LCIS close to the surgical margin of a resection specimen is reported, and reexcision should be considered.

Indexed as

Biopsy, Large-Core NeedleBreast Carcinoma In SituCarcinoma, LobularDisease ManagementFemaleHumansMargins of ExcisionMastectomy, SegmentalPrecancerous ConditionsUnnecessary ProceduresWatchful WaitingCDH1Core biopsyE-cadherinp120Pleomorphic lobular carcinoma in situVariant lobular carcinoma in situ

Identifiers

PMID29413653
PMCPMC5841603
OpenAlexW2774824911

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.