ReviewAdvances in pharmacology (San Diego, Calif.)2018
Imaging Translocator Protein as a Biomarker of Neuroinflammation in Dementia.
Review in Advances in pharmacology (San Diego, Calif.), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 38 citations in OpenAlex.
- 18 kDa Translocator protein (TSPO) is upregulated in rat brain after peripheral nerve injury and downregulated by diroximel fumarate.Brain, behavior, and immunity · 2025Article
- Radiotracers for Imaging of Inflammatory Biomarkers TSPO and COX-2 in the Brain and in the Periphery.International journal of molecular sciences · 2023Review
- Emerging Roles of Cells and Molecules of Innate Immunity in Alzheimer's Disease.International journal of molecular sciences · 2023Review
- Investigating the Prognostic Role of Peripheral Inflammatory Markers in Mild Cognitive Impairment.Journal of clinical medicine · 2023Article
- Low-dose brain irradiation normalizes TSPO and CLUSTERIN levels and promotes the non-amyloidogenic pathway in pre-symptomatic TgF344-AD rats.Journal of neuroinflammation · 2022Article
- Neuroinflammation in World Trade Center responders at midlife: A pilot study using [Brain, behavior, & immunity - health · 2021Article
- Neuroinflammation is highest in areas of disease progression in semantic dementia.Brain : a journal of neurology · 2021Article
- Neuroinflammation and microglial activation in Alzheimer disease: where do we go from here?Nature reviews. Neurology · 2021Review
- Comparison of [11C]-PBR28 Binding Between Persons Living With HIV and HIV-Uninfected Individuals.Journal of acquired immune deficiency syndromes (1999) · 2020Article
- Neuroinflammation PET Imaging: Current Opinion and Future Directions.Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2020Review
- Translocator protein 18 kDa: a potential therapeutic biomarker for post traumatic stress disorder.Metabolic brain disease · 2020Review
- Brain tocopherol levels are associated with lower activated microglia density in elderly human cortex.Alzheimer's & dementia (New York, N. Y.) · 2020Article
- Neuroimaging of traumatic brain injury in military personnel: An overview.Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia · 2019Review
- PET Imaging of the P2X7 Ion Channel with a Novel Tracer [Molecular imaging and biology · 2019Article
- Translocator protein in late stage Alzheimer's disease and Dementia with Lewy bodies brains.Annals of clinical and translational neurology · 2019Article
- Neuroimaging Biomarkers for Alzheimer's Disease.Molecular neurodegeneration · 2019Review
- Molecular Imaging of Neuroinflammation in HIV.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2019Review
- Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
Neuroinflammation has long been considered a potential contributor to neurodegenerative disorders that result in dementia. Accumulation of abnormal protein aggregates in Alzheimer's disease, frontotemporal dementia, and dementia with Lewy bodies is associated with the activation of microglia and astrocytes into proinflammatory states, and chronic low-level activation of glial cells likely contributes to the pathological changes observed in these and other neurodegenerative diseases. The 18kDa translocator protein (TSPO) is a key biomarker for measuring inflammation in the brain via positron emission tomography (PET). Increased TSPO density has been observed in brain tissue from patients with neurodegenerative diseases and colocalizes to activated microglia and reactive astrocytes. Several radioligands have been developed to measure TSPO density in vivo with PET, and these have been used in clinical studies of different dementia syndromes. However, TSPO radioligands have limitations, including low specific-to-nonspecific signal and differential affinity to a polymorphism on the TSPO gene, which must be taken into consideration in designing and interpreting human PET studies. Nonetheless, most PET studies have shown that increased TSPO binding is associated with various dementias, suggesting that TSPO has potential as a biomarker to further explore the role of neuroinflammation in dementia pathogenesis and may prove useful in monitoring disease progression.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.