Evidence map›Paper›PMID 29413459›Full record

ArticleNuclear medicine and biology2018

Benjamin B Kasten, Abhishek Gangrade, Harrison Kim, Jinda Fan, Soldano Ferrone, Cristina R Ferrone, Kurt R Zinn, Donald J Buchsbaum

Erratum issuedOpen access · greenAbstract read
In one paragraph

Article in Nuclear medicine and biology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 41 papers.

0numbers the graph read from it
0cells of the map it votes in
41citing papers in PubMed
3.7field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

41 citing papers in PubMed, 64 citations in OpenAlex.

  1. Picolinamide-functionalized macrocyclic chelators forInorganic chemistry frontiers · 2026
    Article
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  6. Review
  7. Article
  8. EJNMMI radiopharmacy and chemistry · 2025
    Review
  9. Statins inhibit onco-dimerization of the 4Ig isoform of B7-H3.bioRxiv : the preprint server for biology · 2024
    Article
  10. Preclinical Investigation of [Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2024
    Article
  11. Article
  12. B7 homolog 3 in pancreatic cancer.World journal of gastroenterology · 2024
    Review
  13. Article
  14. Review
  15. Review
  16. Review
  17. Article
  18. Primary standardization ofApplied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine · 2022
    Article
  19. Review
  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 1 country.

Benjamin B KastenDepartment of Radiology, University of Alabama at Birmingham, Birmingham, AL, United States. Electronic address: benjaminkasten@uabmc.edu.
Abhishek GangradeDepartment of Radiation Oncology, University of Alabama at Birmingham, Birmingham, AL, United States.
Harrison KimDepartment of Radiology, University of Alabama at Birmingham, Birmingham, AL, United States.
Jinda FanDepartment of Radiology, University of Alabama at Birmingham, Birmingham, AL, United States.
Soldano FerroneDepartment of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA, United States.
Cristina R FerroneDepartment of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA, United States.
Kurt R ZinnInstitute for Quantitative Health Science and Engineering, Department of Radiology, Michigan State University, East Lansing, MI, United States.
Donald J BuchsbaumDepartment of Radiation Oncology, University of Alabama at Birmingham, Birmingham, AL, United States.
University of Alabama at Birmingham · USHarvard University · USMichigan State University · USUniversity of Alabama at Birmingham Hospital · US

Funding

Therapy of pancreatic cancer with 212Pb-labeled B7-H3 specific Ab and LDE225R21CA173120 · NCI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI BUCHSBAUM, DONALD J, FERRONE, SOLDANO · 2014 to 2015
$388k
IL-15 TRiKES-based specific immunotherapy of pancreatic ductal adenocarcinomaR03CA231766 · NCI · MASSACHUSETTS GENERAL HOSPITAL · PI FERRONE, CRISTINA R., FERRONE, SOLDANO · 2018 to 2019
$177k
Safety and anti-tumor activity of B7-H3 CAR T cells in TNBCR03CA223886 · NCI · MASSACHUSETTS GENERAL HOSPITAL · PI DOTTI, GIANPIETRO, FERRONE, SOLDANO · 2018 to 2019
$176k
NCI NIH HHS R03 CA223886NCI NIH HHS R03 CA231766NCI NIH HHS R21 CA173120
6 · The paper itself

Abstract

introductionWe recently validated monoclonal antibody (mAb) 376.96 as an effective carrier for targeted α-particle radioimmunotherapy (RIT) with

methodsIn vitro Scatchard assays assessed the specific binding of

results

conclusionOur results provide evidence for the efficacy of B7-H3 targeted RIT against preclinical models of pancreatic ductal adenocarcinoma (PDAC) and support future studies with

Indexed as

Lead RadioisotopesAnimalsCell DifferentiationCell Line, TumorCell Transformation, NeoplasticFemaleHumansImmunoconjugatesIsotope LabelingMicePancreatic NeoplasmsRadioimmunotherapyTissue DistributionImmunoconjugatesLead-212Lead Radioisotopes(212)PbB7-H3Pancreatic ductal adenocarcinomaRadioimmunotherapy

Identifiers

PMID29413459
PMCPMC5817013
OpenAlexW2779882137

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.