Evidence map›Paper›PMID 29413419›Full record

ReviewTrends in cancer2018

Dissemination from a Solid Tumor: Examining the Multiple Parallel Pathways.

Moriah E Katt, Andrew D Wong, Peter C Searson

Open access · greenAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Trends in cancer, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed
2.4field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 57 citations in OpenAlex.

  1. Article
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  10. Deciphering organotropism reveals therapeutic targets in metastasis.Frontiers in cell and developmental biology · 2025
    Review
  11. Review
  12. Article
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  14. Metastasis from the tumor interior and necrotic core formation are regulated by breast cancer-derived angiopoietin-like 7.Proceedings of the National Academy of Sciences of the United States of America · 2023
    Article
  15. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Moriah E KattInstitute for Nanobiotechnology, 100 Croft Hall, Johns Hopkins University, Baltimore, MD 21218, USA; Department of Materials Science and Engineering, Johns Hopkins University, Baltimore, MD 21218, USA; These authors contributed equally.
Andrew D WongInstitute for Nanobiotechnology, 100 Croft Hall, Johns Hopkins University, Baltimore, MD 21218, USA; Department of Materials Science and Engineering, Johns Hopkins University, Baltimore, MD 21218, USA; These authors contributed equally.
Peter C SearsonInstitute for Nanobiotechnology, 100 Croft Hall, Johns Hopkins University, Baltimore, MD 21218, USA; Department of Materials Science and Engineering, Johns Hopkins University, Baltimore, MD 21218, USA; Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA. Electronic address: searson@jhu.edu.
Johns Hopkins University · US

Funding

An engineered platform for the study of metastasis (PQ #24)R01CA170629 · NCI · JOHNS HOPKINS UNIVERSITY · PI SEARSON, PETER C · 2012 to 2015
$1.3M
NCI NIH HHS R01 CA170629
6 · The paper itself

Abstract

Metastasis can be generalized as a linear sequence of events whereby halting one or more steps in the cascade may reduce tumor cell dissemination and ultimately improve patient outcomes. However, metastasis is a complex process with multiple parallel mechanisms of dissemination. Clinical strategies focus on removing the primary tumor and/or treating distant metastases through chemo- or immunotherapies. Successful strategies for blocking metastasis will need to address the parallel mechanisms of dissemination and identify common bottlenecks. Here, we review the current understanding of common dissemination pathways for tumors. Understanding the complexities of metastasis will guide the design of new therapies that halt dissemination.

Indexed as

HumansNeoplasm InvasivenessNeoplasmsNeoplastic Cells, Circulatingdisseminationextravasationintravasationmetastasistumor microenvironmenttumor vasculature

Identifiers

PMID29413419
PMCPMC5806201
OpenAlexW2783300293

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.