ArticleInternational journal of radiation oncology, biology, physics2018
Outcome After Radiation Therapy for Langerhans Cell Histiocytosis Is Dependent on Site of Involvement.
Article in International journal of radiation oncology, biology, physics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 26 citations in OpenAlex.
- Local disease control in patients with Erdheim-Chester disease treated with external beam radiation therapy.British journal of haematology · 2026Article
- Origin, diagnosis and treatment of periocular Histiocytic disorders- state-of-the-art review.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2026Review
- [A case of adult temporal bone langerhans cell histiocytosis presenting as posterior canal dehiscence syndrome and literature review].Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology head and neck surgery · 2025Review
- Treating metastatic extraocular retinoblastoma complicated with Langerhans cell histiocytosis.GMS ophthalmology cases · 2025Article
- Stereotactic radiosurgery for intracranial Langerhans cell histiocytosis: A multi-institutional case series with long-term follow-up.Brain & spine · 2025Article
- Langerhans Cell Histiocytosis Masked by Constipation: A Case Report and Literature Review.Cureus · 2024Article
- A solitary osteolytic lesion with pathological fracture in the cervical spine - a case report.BMC musculoskeletal disorders · 2023Article
- Langerhans cell histiocytosis misdiagnosed as thyroid malignancy: A case report.World journal of clinical cases · 2023Article
- Aggressive unifocal bone Langerhans cell histiocytosis with soft tissue extension both responsive to radiotherapy: a case report.Radiation oncology (London, England) · 2022Article
- Article
- Three decades of progress from surgery to medical therapy for isolated neuroaxisJournal of neurosurgery. Case lessons · 2021Article
- Isolated Bone Lesions in the Mandible and Maxilla of Langerhans Cell Histiocytosis Treated with Fractionated Stereotactic Low-Dose Radiotherapy: Case Report and 5-Year Follow-Up.Case reports in dentistry · 2021Article
- A Dose-Response Relationship to Radiotherapy for Cutaneous Lesions of Langerhans Cell Histiocytosis.Case reports in oncological medicine · 2021Article
- Mandibular fracture due to rare manifestation of Langerhans cell histiocytosis.Revista Brasileira de terapia intensiva · 2019Article
- A Case Report of Radiotherapy for Skull Lesions of Langerhans Cell Histiocytosis With Dural Invasion.Cancer diagnosis & prognosisArticle
- Langerhans cell histiocytosis in sphenoid sinus with vision impairment: Case report and literature review.Science progressReview
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
Abstract
purposeTo characterize the efficacy and safety of radiation therapy in a contemporary Langerhans cell histiocytosis (LCH) cohort and to explore whether there are sites at higher risk for local recurrence. PATIENTS AND
methodsBetween 1995 and 2015 we identified 39 consecutive LCH patients who were treated primarily with radiation therapy. Patients were staged by single/multisystem involvement and established risk organ criteria. In 46 irradiated lesions, clinical and radiologic responses were evaluated at multiple time points after radiation therapy. Patient demographics, treatment, and local failure were compared by site of lesion.
resultsMedian age at radiation therapy was 35 years (range, 1.5-67 years). Twelve patients had multisystem involvement, and of those, 5 patients had disease in organs considered to be high risk. The following sites were irradiated: bone (31), brain (6), skin (3), lymph node (3), thyroid (2), and nasopharynx (1). Median dose was 11.4 Gy (range, 7.5-50.4 Gy). At a median follow-up of 45 months (range, 6-199 months), local recurrence or progression was noted in 5 of 46 lesions (11%). There were no local failures of the 31 bone lesions evaluated, whereas the 3-year freedom from local failure in the 15 non-bone lesions was 63% (95% confidence interval 32-83%; P=.0008). Local failures occurred in 2 of 3 skin lesions, in 2 of 6 brain lesions, and 1 of 3 lymph node lesions. Deaths were recorded in 5 of 39 patients (13%), all of whom were adults with multisystem disease.
conclusionRadiation therapy is a safe and effective measure for providing local control of LCH involving the bone. Whereas bone lesions are well controlled with low doses of radiation, disease in other tissues, such as the skin and brain, may require higher doses of radiation or additional treatment modalities.
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