Evidence map›Paper›PMID 29412738›Full record

ArticleCellular reprogramming2018

Reciprocity of Action of Increasing Oct4 and Repressing p53 in Transdifferentiation of Mouse Embryonic Fibroblasts into Cardiac Myocytes.

Hongran Wang, Shuying Zhao, Michelle Barton, Todd Rosengart, Austin J Cooney

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cellular reprogramming, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.4field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

  1. Review
  2. Article
  3. High levels ofTranslational cancer research · 2020
    Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 4 institutions in 1 country.

Hongran Wang1 Department of Pediatrics, Dell Pediatric Research Institute, University of Texas at Austin Dell Medical School , Austin, Texas.
Shuying Zhao1 Department of Pediatrics, Dell Pediatric Research Institute, University of Texas at Austin Dell Medical School , Austin, Texas.
Michelle Barton2 Department of Epigenetics and Molecular Carcinogenesis, Center for Stem Cell and Developmental Biology, UT MD Anderson Cancer Center , Houston, Texas.
Todd Rosengart3 Department of Surgery, Baylor College of Medicine , Houston, Texas.
Austin J Cooney1 Department of Pediatrics, Dell Pediatric Research Institute, University of Texas at Austin Dell Medical School , Austin, Texas.
Dell Children's Medical Center of Central Texas · USBaylor College of Medicine · USDELL (United States) · USThe University of Texas MD Anderson Cancer Center · US

Funding

In Situ Cardiac Infarct Cellular ReprogrammingR01HL121294 · NHLBI · BAYLOR COLLEGE OF MEDICINE · PI ROSENGART, TODD K · 2015 to 2018
$2.7M
NHLBI NIH HHS R01 HL121294
6 · The paper itself

Abstract

p53 is a barrier to somatic cell reprogramming. Deletion or transient suppression of p53 increases the efficiency of reprogramming of somatic cells into induced pluripotent stem cells. Whether p53 represents an obstacle to a similar process transdifferentiation of somatic cells is unknown. However, it is predicted that inhibition of p53 would promote transdifferentiation of fibroblasts into cardiomyocytes. In this study, the effect of p53 on the capacity of cardiogenic transdifferentiation is evaluated using p53 wild-type (p53

Indexed as

AnimalsCell TransdifferentiationEctodermEndodermFibroblastsGene Expression Regulation, DevelopmentalGenetic MarkersHeterozygoteLong-Term Synaptic DepressionMesodermMiceMice, Inbred C57BLMice, KnockoutMouse Embryonic Stem CellsMutationMyocytes, CardiacGenetic MarkersOctamer Transcription Factor-3Pou5f1 protein, mouseTrp53 protein, mouseTumor Suppressor Protein p53cardiomyocyte differentiationfibroblastOct4p53reprogrammingtransdifferentiation

Identifiers

PMID29412738
PMCPMC5824656
OpenAlexW2792596538

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.