ArticleJournal of athletic training2018
Lateral Ankle Sprain in a Mouse Model: Lifelong Sensorimotor Dysfunction.
Article in Journal of athletic training, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 17 citations in OpenAlex.
- Corticospinal tract alterations after ankle sprain in adolescence: Insights from the mouse model.Sports medicine and health science · 2025Article
- Effects of chronic ankle instability after grade I ankle sprain on the post-traumatic osteoarthritis.Arthritis research & therapy · 2024Article
- Mouse model of subtalar post-traumatic osteoarthritis caused by subtalar joint instability.Journal of orthopaedic surgery and research · 2022Article
- A new mouse model of ankle instability induced by multiple mechanical sprains with controlled inversion angle and speed.Frontiers in bioengineering and biotechnology · 2022Article
- A mouse model of ankle-subtalar joint complex instability induced post-traumatic osteoarthritis.Journal of orthopaedic surgery and research · 2021Article
- Prolonged Rest, Long-Term Dynamic Balance, and Gait in a Mouse Ankle-Sprain Model.Journal of athletic training · 2019Article
- Analysis for osteoarthritis of the ankle joint in a mouse model of chronic ankle instability.Science progressArticle
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
contextAnkle sprains are the most common orthopaedic injury that occurs during sport and physical activity. Many individuals who sprain their ankles develop chronic ankle instability (CAI), a condition characterized by recurrent injury, decreased physical activity, and decreased quality of life. These residual impairments are believed to persist for the remainder of the patient's life, in part due to the link between CAI and posttraumatic ankle osteoarthritis. However, this belief remains speculative due to the lack of long-term prospective investigations.
objectiveTo use a mouse model of mild (MILD) and severe (SEVERE) ankle sprains to quantify balance and locomotor adaptations across the lifespan.
designCohort study.
settingUniversity research laboratory. PATIENTS OR OTHER
participantsFifty male mice (CBA/J) were randomly placed into a control (SHAM), MILD, or SEVERE group and housed individually. INTERVENTION(S): The MILD group underwent surgical transection of a single right hind-limb lateral ankle ligament, and the SEVERE group had 2 of the lateral ligaments transected. The SHAM group underwent a sham surgery during which no lateral ligaments were transected. MAIN OUTCOME MEASURE(S): After surgically inducing the ankle sprain, we measured balance and gait using a balance beam and footprint test before and every 6 weeks for 78 weeks.
resultsAge-related declines in balance but not stride length were exacerbated by an ankle sprain ( P < .001). Balance and stride lengths changed with age ( P < .001). Foot slips were worse in the SEVERE (4.32 ± 0.98) and MILD (3.53 ± 0.98) groups than in the SHAM group (2.16 ± 0.99; P < .001). Right-limb stride length was shorter in the SEVERE group (6.45 cm ± 0.41 cm) than in the SHAM group (6.87 cm ± 0.40 cm; P = .04).
conclusionsTransecting the lateral ligaments of a mouse hind foot resulted in lifelong sensorimotor dysfunction. Declines starting at 42 weeks postinjury may have represented the onset of posttraumatic osteoarthritis.
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