Evidence map›Paper›PMID 29412477›Full record

ArticleChemistry (Weinheim an der Bergstrasse, Germany)2018

CCR5 RNA Pseudoknots: Residue and Site-Specific Labeling correlate Internal Motions with microRNA Binding.

Bin Chen, Andrew P Longhini, Felix Nußbaumer, Christoph Kreutz, Jonathan D Dinman, T Kwaku Dayie

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Chemistry (Weinheim an der Bergstrasse, Germany), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Nature communications · 2026
    Article
  2. Application of NMR to Large RNAs.Journal of molecular biology · 2025
    Review
  3. Review
  4. Strategies for Covalent Labeling of Long RNAs.Chembiochem : a European journal of chemical biology · 2021
    Review
  5. Review
  6. Article
  7. RNA Dynamics by NMR Spectroscopy.Chembiochem : a European journal of chemical biology · 2019
    Review
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Bin ChenDepartment of Cell Biology and Molecular Genetics, University of Maryland, 4062 Campus Dr., College Park, MD, 20742, USA.ORCID http://orcid.org/0000-0001-7501-4229
Andrew P LonghiniCenter for Biomolecular Structure & Organization, Department of Chemistry & Biochemistry, University of Maryland, 8314 Paint Branch Dr., College Park, MD, 20782, USA.
Felix NußbaumerInstitute of Organic Chemistry and Center for Molecular Biosciences, Innsbruck (CMBI), University of Innsbruck, Innrain 80/82, 6020, Innsbruck, Austria.
Christoph KreutzInstitute of Organic Chemistry and Center for Molecular Biosciences, Innsbruck (CMBI), University of Innsbruck, Innrain 80/82, 6020, Innsbruck, Austria.
Jonathan D DinmanDepartment of Cell Biology and Molecular Genetics, University of Maryland, 4062 Campus Dr., College Park, MD, 20742, USA.ORCID http://orcid.org/0000-0002-2402-9698
T Kwaku DayieCenter for Biomolecular Structure & Organization, Department of Chemistry & Biochemistry, University of Maryland, 8314 Paint Branch Dr., College Park, MD, 20782, USA.ORCID http://orcid.org/0000-0002-7119-4362

Funding

The Center for HIV RNA Studies (CRNA)U54GM103297 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI TELESNITSKY, ALICE · 2017 to 2018
$10.2M
Regulation of programmed -1 ribosomal frameshifting by micro-RNAsR01GM117177 · NIGMS · UNIV OF MARYLAND, COLLEGE PARK · PI DINMAN, JONATHAN D · 2015 to 2018
$1.2M
NIGMS NIH HHS R01 GM117177NIGMS NIH HHS U54 GM103297
6 · The paper itself

Abstract

Conformational dynamics of RNA molecules play a critical role in governing their biological functions. Measurements of RNA dynamic behavior sheds important light on sites that interact with their binding partners or cellular stimulators. However, such measurements using solution-state NMR are difficult for large RNA molecules (>70 nt; nt=nucleotides) owing to severe spectral overlap, homonuclear

Indexed as

Models, MolecularMicroRNAsNuclear Magnetic Resonance, BiomolecularReceptors, CCR5Solid-Phase Synthesis TechniquesMicroRNAsReceptors, CCR5CCR5 mRNA pseudoknotdynamicsmicroRNANMR spectroscopyRNA solid-phase synthesis

Identifiers

PMID29412477
PMCPMC7640883

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.