Evidence map›Paper›PMID 29412389›Full record

ArticleArchives of endocrinology and metabolism2017

High prevalence of insulin resistance among Brazilian chronic hepatitis C patients.

Livia Melo Villar, Gabriela Cardoso Caldas, Leticia de Paula Scalioni, Juliana Custódio Miguel, Elisangela Ferreira da Silva, Vanessa Alves Marques, Cristiane Alves Villela-Nogueira, Lia Laura Lewis-Ximenez, Elisabeth Lampe

Open access · diamondAbstract read
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In one paragraph

Article in Archives of endocrinology and metabolism, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Livia Melo VillarLaboratório de Hepatite Viral, Instituto Oswaldo Cruz (Fiocruz), Rio de Janeiro, RJ, Brasil.
Gabriela Cardoso CaldasLaboratório de Hepatite Viral, Instituto Oswaldo Cruz (Fiocruz), Rio de Janeiro, RJ, Brasil.
Leticia de Paula ScalioniLaboratório de Hepatite Viral, Instituto Oswaldo Cruz (Fiocruz), Rio de Janeiro, RJ, Brasil.
Juliana Custódio MiguelLaboratório de Hepatite Viral, Instituto Oswaldo Cruz (Fiocruz), Rio de Janeiro, RJ, Brasil.
Elisangela Ferreira da SilvaLaboratório de Hepatite Viral, Instituto Oswaldo Cruz (Fiocruz), Rio de Janeiro, RJ, Brasil.
Vanessa Alves MarquesLaboratório de Hepatite Viral, Instituto Oswaldo Cruz (Fiocruz), Rio de Janeiro, RJ, Brasil.
Cristiane Alves Villela-NogueiraUnidade de Hepatologia, Departamento de Clínica Médica, Hospital Universitário Clementino Fraga Filho (HUCFF), Universidade Federal do Rio de Janeiro (UFRJ), Rio de Janeiro, RJ, Brasil.
Lia Laura Lewis-XimenezLaboratório de Hepatite Viral, Instituto Oswaldo Cruz (Fiocruz), Rio de Janeiro, RJ, Brasil.
Elisabeth LampeLaboratório de Hepatite Viral, Instituto Oswaldo Cruz (Fiocruz), Rio de Janeiro, RJ, Brasil.
Universidade Federal do Rio de Janeiro · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveThis study aims to estimate the prevalence of insulin resistance (IR) among chronic hepatitis C (CHC) patients and their related laboratory and demographic data. SUBJECTS AND

methodsIn this study, non-diabetic CHC patients referred to Viral Hepatitis Ambulatories from Rio de Janeiro (Brazil) donated blood samples. Insulin was measured using a chemiluminescence immunoassay. IR was determined by HOMA-IR, where HOMA-IR > 2 was defined as IR.

resultsA total of 214 CHC patients were recruited (123 females aged 53.6 years ± 10.9 years). IR was present in 133 patients (62.1%) and was associated in bivariate analysis to higher mean values of age (p = 0.040), triglycerides (p = 0.032), glucose (p = 0.000), insulin (p = 0.000), waist circumference (p = 0.001), and body mass index (p = 0.007); however, none of these variables were significant in the multivariate analysis.

conclusionsThe high prevalence of IR was observed among CHC patients, and there was no difference in clinical or laboratory parameters when both groups were compared in the multivariate analysis. This high IR prevalence could lead to a high risk for development of cardiovascular disease and metabolic disorders.

Indexed as

Body Mass IndexBrazilFemaleHepatitis C, ChronicHumansInsulin ResistanceLuminescent MeasurementsMaleMiddle AgedPrevalence

Identifiers

PMID29412389
PMCPMC10522051
OpenAlexW2789340371

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.