Evidence map›Paper›PMID 29412359›Full record

ArticleMemorias do Instituto Oswaldo Cruz2018

Potential application of rLc36 protein for diagnosis of canine visceral leishmaniasis.

Camila Tita Nogueira, Mayara Lúcia Del Cistia, Ana Carolina Urbaczek, Márcia Mg Jusi, Angela Maria Arenas Velásquez, Rosângela Zacarias Machado, Henrique Ferreira, Flávio Henrique-Silva, Hélio Langoni, Paulo Inácio da Costa and 1 more

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Memorias do Instituto Oswaldo Cruz, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.6field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Camila Tita NogueiraUniversidade Estadual Paulista, Instituto de Química, Campus de Araraquara, Araraquara, SP, Brasil.
Mayara Lúcia Del CistiaUniversidade Estadual Paulista, Faculdade de Ciências Farmacêuticas, Campus de Araraquara, Araraquara, SP, Brasil.
Ana Carolina UrbaczekUniversidade de São Paulo, Instituto de Química, Campus de São Carlos, São Carlos, SP, Brasil.
Márcia Mg JusiUniversidade Estadual Paulista, Faculdade de Ciências Agrárias e Veterinárias, Campus de Jaboticabal, Jaboticabal, SP, Brasil.
Angela Maria Arenas VelásquezUniversidade Estadual Paulista, Instituto de Química, Campus de Araraquara, Araraquara, SP, Brasil.
Rosângela Zacarias MachadoUniversidade Estadual Paulista, Faculdade de Ciências Agrárias e Veterinárias, Campus de Jaboticabal, Jaboticabal, SP, Brasil.
Henrique FerreiraUniversidade Estadual Paulista, Instituto de Biociências, Campus de Rio Claro, Rio Claro, SP, Brasil.
Flávio Henrique-SilvaUniversidade Federal de São Carlos, Departamento de Genética e Evolução, São Carlos, SP, Brasil.
Hélio LangoniUniversidade Estadual Paulista, Faculdade de Medicina Veterinária e de Zootecnia, Campus de Botucatu, Botucatu, SP, Brasil.
Paulo Inácio da CostaUniversidade Estadual Paulista, Faculdade de Ciências Farmacêuticas, Campus de Araraquara, Araraquara, SP, Brasil.
Márcia As GraminhaUniversidade Estadual Paulista, Instituto de Química, Campus de Araraquara, Araraquara, SP, Brasil.
Universidade Estadual Paulista (Unesp) · BRUniversidade de São Paulo · BRUniversidade Federal de São Carlos · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Visceral leishmaniasis (VL) is fatal if left untreated. Infected dogs are important reservoirs of the disease, and thus specific identification of infected animals is very important. Several diagnostic tests have been developed for canine VL (CVL); however, these tests show varied specificity and sensitivity. The present study describes the recombinant protein rLc36, expressed by Leishmania infantum, as potential antigen for more sensitive and specific diagnosis of CVL based on an immunoenzymatic assay. The concentration of 1.0 μg/mL of rLc36 enabled differentiation of positive and negative sera and showed a sensitivity of 85% and specificity of 71% (with 95% confidence), with an accuracy of 76%.

Indexed as

AnimalsDog DiseasesDogsElectrophoresis, Polyacrylamide GelEnzyme-Linked Immunosorbent AssayLeishmania infantumLeishmaniasis, VisceralMaleMiceProtozoan ProteinsSensitivity and SpecificityProtozoan Proteins

Identifiers

PMID29412359
PMCPMC5804312
OpenAlexW2790497660

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.