ArticleMucosal immunology2018
Lymphoid tissue-resident Alcaligenes LPS induces IgA production without excessive inflammatory responses via weak TLR4 agonist activity.
Article in Mucosal immunology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
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Who cites it
25 citing papers in PubMed, 61 citations in OpenAlex.
- Sublingual bivalent vaccination with PspA-C-CPE and Alcaligenes lipid A induces protective immunity against both Streptococcus pneumoniae and Clostridium perfringens.Research square · 2026Article
- Diversity of oligosaccharides in lipooligosaccharides of Akkermansia muciniphila and its anti-atherosclerotic activity.Natural products and bioprospecting · 2026Article
- Alcaligenes lipid A as a sublingual adjuvant to augment protective immune responses in the respiratory and gastrointestinal tracts.International immunology · 2026Article
- The hidden language of gut-derived lipopolysaccharides: fine chemistry, huge immunological consequences.Chemical science · 2026Review
- The Safety ofViruses · 2026Article
- Commensal bacterial glycosylation at the interface of host-bacteria interactions.Gut microbes · 2025Review
- Alcaligenes lipid A functions as a superior mucosal adjuvant to monophosphoryl lipid A via the recruitment and activation of CD11b+ dendritic cells in nasal tissue.International immunology · 2024Article
- Immunoglobulin A antibody composition is sculpted to bind the self gut microbiome.Science immunology · 2022Article
- Changes of gut microbiota in colorectal cancer patients withFrontiers in cellular and infection microbiology · 2022Article
- Lipid A-Mediated Bacterial-Host Chemical Ecology: Synthetic Research of Bacterial Lipid As and Their Development as Adjuvants.Molecules (Basel, Switzerland) · 2021Review
- Lipopolysaccharide from Gut-Associated Lymphoid-Tissue-Resident Alcaligenes faecalis: Complete Structure Determination and Chemical Synthesis of Its Lipid A.Angewandte Chemie (International ed. in English) · 2021Article
- Review
- Lipopolysaccharide Derived From the Lymphoid-Resident Commensal BacteriaFrontiers in immunology · 2021Article
- Chemically SynthesizedFrontiers in pharmacology · 2021Article
- Chemically SynthesizedMicroorganisms · 2020Article
- Adjuvant Activity of Synthetic Lipid A ofVaccines · 2020Article
- Diversity of energy metabolism in immune responses regulated by micro-organisms and dietary nutrition.International immunology · 2020Review
- Fatty acid metabolism in the host and commensal bacteria for the control of intestinal immune responses and diseases.Gut microbes · 2020Review
- Persistent colonization of non-lymphoid tissue-resident macrophages by Stenotrophomonas maltophilia.International immunology · 2020Article
- Review
Corrections and comments
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Authors and funding
13 authors at 6 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Alcaligenes are opportunistic commensal bacteria that reside in gut-associated lymphoid tissues such as Peyer's patches (PPs); however, how they create and maintain their homeostatic environment, without inducing an excessive inflammatory response remained unclear. We show here that Alcaligenes-derived lipopolysaccharide (Alcaligenes LPS) acts as a weak agonist of toll-like receptor 4 and promotes IL-6 production from dendritic cells, which consequently enhances IgA production. The inflammatory activity of Alcaligenes LPS was weaker than that of Escherichia coli-derived LPS and therefore no excessive inflammation was induced by Alcaligenes LPS in vitro or in vivo. Alcaligenes LPS also showed adjuvanticity, inducing antigen-specific immune responses without excessive inflammation. These findings reveal the presence of commensal bacteria-mediated homeostatic inflammatory conditions within PPs that produce optimal IgA induction without causing pathogenic inflammation and suggest that Alcaligenes LPS could be a safe and potent adjuvant.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.