Evidence map›Paper›PMID 29411531›Full record

Observational studyCatheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions2018

Aspirin and clopidogrel high on-treatment platelet reactivity and genetic predictors in peripheral arterial disease.

Khung-Keong Yeo, Ehrin J Armstrong, Javier E López, Debbie C Chen, Gregory G Westin, Chin-Shang Li, David Anderson, Amy Hua, Anil Singapuri, Ezra A Amsterdam and 2 more

Open access · greenAbstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
1.5field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it, 22 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Review
  5. Article
  6. ShouldPharmacogenomics and personalized medicine · 2020
    Article
  7. Factors Influencing Aspirin Hyporesponsiveness in Elderly Chinese Patients.Medical science monitor : international medical journal of experimental and clinical research · 2019
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors at 7 institutions in 2 countries.

Khung-Keong YeoDivision of Cardiovascular Medicine and the Vascular Center, University of California, Davis, California.ORCID 0000-0002-5457-4881
Ehrin J ArmstrongDivision of Cardiovascular Medicine and the Vascular Center, University of California, Davis, California.ORCID 0000-0002-5682-8363
Javier E LópezDivision of Cardiovascular Medicine, University of California, Davis, California.
Debbie C ChenDepartment of Medicine, Massachusetts General Hospital, Boston, Massachusetts.
Gregory G WestinDivision of Vascular and Endovascular Surgery, NYU Langone Medical Center, New York, New York.
Chin-Shang LiDivision of Biostatistics, Department of Public Health Sciences, University of California, Davis, California.
David AndersonDepartment of Internal Medicine, University of California, San Francisco, California.
Amy HuaDivision of Cardiovascular Medicine, University of California, Davis, California.
Anil SingapuriDivision of Cardiovascular Medicine, University of California, Davis, California.
Ezra A AmsterdamDivision of Cardiovascular Medicine, University of California, Davis, California.
Nipavan ChiamvimonvatDivision of Cardiovascular Medicine, University of California, Davis, California.
John R LairdDivision of Cardiovascular Medicine and the Vascular Center, University of California, Davis, California.
University of California, Davis · USMassachusetts General Hospital · USNational Heart Centre Singapore · SGNYU Langone Health · USUniversity of California, San Francisco · USVA Eastern Colorado Health Care System · USVA Northern California Health Care System · US

Funding

UC Davis Clinical and Translational Science CenterUL1TR001860 · NCATS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI KENYON, NICHOLAS J., LYLES, COURTNEY REES · 2016 to 2025
$47.3M
UC Davis Clinical and Translational Science CenterUL1TR000002 · NCATS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI BERGLUND, LARS F · 2012 to 2015
$12.2M
Functional Interactions of Cardiac Ion ChannelsR01HL085844 · NHLBI · UNIVERSITY OF CALIFORNIA AT DAVIS · PI CHIAMVIMONVAT, NIPAVAN · 2007 to 2025
$7.3M
Translational Study of Cardiac DysfunctionR01HL085727 · NHLBI · UNIVERSITY OF CALIFORNIA AT DAVIS · PI CHIAMVIMONVAT, NIPAVAN, SIRISH, PADMINI · 2008 to 2022
$5.7M
UC Davis Clinical and Translational Science CenterKL2TR000134 · NCATS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI BERGLUND, LARS F · 2012 to 2015
$3.1M
Decoding the enigma of cardiac amplificationR01HL137228 · NHLBI · UNIVERSITY OF CALIFORNIA AT DAVIS · PI CHIAMVIMONVAT, NIPAVAN · 2017 to 2020
$2.2M
Regulation of ion channels in the heartI01BX000576 · VA · VA NORTHERN CALIFORNIA HEALTH CARE SYS · PI CHIAMVIMONVAT, NIPAVAN · 2009 to 2019
–
Metabolomics study in patients post myocardial infarctionI01CX001490 · VA · VA NORTHERN CALIFORNIA HEALTH CARE SYS · PI CHIAMVIMONVAT, NIPAVAN · 2017 to 2021
–
BLRD VA I01 BX000576CSRD VA I01 CX001490NCATS NIH HHS KL2 TR000134NCATS NIH HHS UL1 TR001860NHLBI NIH HHS R01 HL085727NHLBI NIH HHS R01 HL085844NHLBI NIH HHS R01 HL137228
6 · The paper itself

Abstract

objectivesOur aims were to examine the prevalence and genetic predictors of aspirin and clopidogrel high on-treatment platelet reactivity (HoTPR), and associated adverse cardiovascular outcomes in patients with peripheral arterial disease (PAD).

backgroundThe association of aspirin and clopidogrel HoTPR with outcomes in PAD remains unclear.

methodsThis is a prospective cohort study of patients with angiographically documented PAD involving carotid and lower extremity arteries. Aspirin and clopidogrel HoTPR (using the VerifyNow Assay) and associated genetic predictors were compared to clinical outcomes. The primary end-point was a composite of major adverse cardiovascular events: all-cause mortality, myocardial infarction, stroke, target vessel revascularization (TVR) and limb-loss in patients who underwent extremity intervention.

resultsThe study was stopped prematurely due to slow patient enrolment. Of 195 patients enrolled, the primary analysis was performed in 154 patients taking both drugs. Aspirin HoTPR was present in 31 (20%) and clopidogrel HoTPR in 76 (49%) patients. There was a trend toward more primary composite outcome events with PRU ≥ 235 (52% freedom-from-event rate vs. 70% for PRU < 235; P = 0.09). TVR was higher in those with PRU ≥ 235 (20 vs. 6%, unadjusted P = 0.02). There was no association between aspirin HoTPR and combined outcomes. Single nucleotide polymorphisms in serum paraoxonase/arylesterase 1 (PON1) gene was associated with aspirin HoTPR (P = 0.005) while SNP in phospholipase A2, group III (PLA2G3) gene was associated with clopidogrel HoTPR (P = 0.002).

conclusionClopidogrel HoTPR was significantly associated with TVR, while aspirin HoTPR was not associated with adverse clinical outcomes in patients with PAD.

Indexed as

AdultAgedAged, 80 and overAmputation, SurgicalAngiographyAryldialkylphosphataseAspirinCaliforniaClopidogrelDrug ResistanceDrug Therapy, CombinationFemaleGroup III Phospholipases A2HumansLimb SalvageMaleAryldialkylphosphataseAspirinClopidogrelGroup III Phospholipases A2PLA2G3 protein, humanPlatelet Aggregation InhibitorsPON1 protein, humanantiplatelet therapygeneticsperipheral arterial disease

Identifiers

PMID29411531
PMCPMC5997520
OpenAlexW2792964904

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.