Evidence map›Paper›PMID 29411521›Full record

ArticleJournal of neuropsychology2019

Words fail: Lesion-symptom mapping of errors of omission in post-stroke aphasia.

Qi Chen, Erica Middleton, Daniel Mirman

Open access · greenAbstract read
In one paragraph

Article in Journal of neuropsychology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
3.0field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 44 citations in OpenAlex.

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  16. Retrieval practice and spacing effects in multi-session treatment of naming impairment in aphasia.Cortex; a journal devoted to the study of the nervous system and behavior · 2019
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 3 institutions in 2 countries.

Qi ChenSchool of Psychology, Center for Studies of Psychological Application and Guangdong Key Laboratory of Mental Health and Cognitive Science, South China Normal University, Guangzhou, China.
Erica MiddletonMoss Rehabilitation Research Institute, Elkins Park, Pennsylvania, USA.
Daniel MirmanMoss Rehabilitation Research Institute, Elkins Park, Pennsylvania, USA.ORCID 0000-0001-5472-0220
Moss Rehabilitation Hospital · USSouth China Normal University · CNUniversity of Alabama at Birmingham · US

Funding

Retrieval Practice Principles: A Theory of Learning for Aphasia RehabilitationR01DC015516 · NIDCD · THOMAS JEFFERSON UNIVERSITY · PI Erica Lee Middleton · 2017 to 2026
$4.9M
Dynamics of Spoken Word Comprehension in AphasiaR01DC010805 · NIDCD · DREXEL UNIVERSITY · PI MIRMAN, DANIEL · 2010 to 2014
$1.8M
Delineating the Impact of Retrieval Practice in AphasiaR03DC012426 · NIDCD · ALBERT EINSTEIN HEALTHCARE NETWORK · PI MIDDLETON, ERICA LEE · 2012 to 2014
$450k
NIDCD NIH HHS R01 DC010805NIDCD NIH HHS R01 DC015516NIDCD NIH HHS R03 DC012426
6 · The paper itself

Abstract

Impaired object naming is a core deficit in post-stroke aphasia, which can manifest as errors of commission - producing an incorrect word or a non-word - or as errors of omission - failing to attempt to name the object. Detailed behavioural, computational, and neurological investigations of errors of commission have played a key role in the development of neurocognitive models of word production. In contrast, the neurocognitive basis of omission errors is radically underspecified despite being a prevalent phenomenon in aphasia and other populations. The prevalence of omission errors makes their neurocognitive basis important for characterizing an individual's deficits and, ideally, for personalizing treatment and evaluating treatment outcomes. This study leveraged established relationships between lesion location and errors of commission to investigate omission errors in picture naming. Omission error rates from the Philadelphia Naming Test for 123 individuals with post-stroke aphasia were analysed using support vector regression lesion-symptom mapping. Omission errors were most strongly associated with left frontal and mid-anterior temporal lobe lesions. Computational model analysis further showed that omission errors were positively associated with impaired semantically driven lexical retrieval rather than phonological retrieval. These results suggest that errors of omission in aphasia predominantly arise from lexical-semantic deficits in word retrieval and selection from a competitor set.

Indexed as

AdultAgedAphasiaBrain MappingComputer SimulationFemaleHumansLanguageMagnetic Resonance ImagingMaleMiddle AgedModels, NeurologicalNeuropsychological TestsPrecision MedicinePsychomotor PerformanceRegression Analysisaphasialesion-symptom mappingomission errorspicture namingword production

Identifiers

PMID29411521
PMCPMC6367056
OpenAlexW2794299832

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.