Evidence map›Paper›PMID 29411410›Full record

ArticleBritish journal of clinical pharmacology2018

Discontinuities and disruptions in drug dosage guidelines for the paediatric population.

Kate M Chitty, Bosco Chan, Camille L Pulanco, Sonya Luu, Oluwaseun Egunsola, Nicholas A Buckley

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Article in British journal of clinical pharmacology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Kate M ChittyDiscipline of Pharmacology, Sydney Medical School, Translational Australian Clinical Toxicology Program, The University of Sydney, NSW, Australia, 2006.ORCID 0000-0002-7119-8953
Bosco ChanDiscipline of Pharmacology, Sydney Medical School, Translational Australian Clinical Toxicology Program, The University of Sydney, NSW, Australia, 2006.
Camille L PulancoDiscipline of Pharmacology, Sydney Medical School, Translational Australian Clinical Toxicology Program, The University of Sydney, NSW, Australia, 2006.
Sonya LuuDiscipline of Pharmacology, Sydney Medical School, Translational Australian Clinical Toxicology Program, The University of Sydney, NSW, Australia, 2006.
Oluwaseun EgunsolaDiscipline of Pharmacology, Sydney Medical School, Translational Australian Clinical Toxicology Program, The University of Sydney, NSW, Australia, 2006.
Nicholas A BuckleyDiscipline of Pharmacology, Sydney Medical School, Translational Australian Clinical Toxicology Program, The University of Sydney, NSW, Australia, 2006.ORCID 0000-0002-6326-4711

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimsThis study investigates paediatric drug dosage guidelines with the aim of investigating their agreement with body surface area (BSA) scaling principles.

methodsA total of 454 drug dosage guidelines listed in the AMH-CDC 2015 were examined. Data extracted included the administration, frequency and dose per age bracket from 0 to 18 years. Drug treatments were categorized as follows: (1) The same dose recommendation in milligrams per kilogram (mg kg

resultsMost drug treatments (63%) have the same mg kg

conclusionsPaediatric dosage guidelines are based on weight-based formulas, available dosing formulations and prior patterns of use. Substantial variation from doses predicted by BSA scaling are common, as are large shifts in recommended doses at age thresholds. Further research is required to determine if better outcomes could be achieved by adopting biologically based scaling of paediatric doses.

Indexed as

Body Surface AreaBody WeightDrug Dosage CalculationsPractice Guidelines as TopicAdolescentAge FactorsChildChild, PreschoolHumansInfantInfant, NewbornPharmaceutical PreparationsPharmaceutical Preparationsallometric scalingAustralian Medicines Handbook Children's Dosing Companion (AMH-CDC)body surface areapaediatric dosing

Identifiers

PMID29411410
PMCPMC5903237

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.