ReviewCurrent reviews in musculoskeletal medicine2018
The Role of Biologic Therapy in Rotator Cuff Tears and Repairs.
Review in Current reviews in musculoskeletal medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 51 citations in OpenAlex.
- Footprint preparation with nanofractures in a supraspinatus repair cuts in half the retear rate at 1-year follow-up. A randomized controlled trial.Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA · 2021Trial
- Exosomes for the Management of Rotator Cuff Injuries: A Systematic Review.Indian journal of orthopaedics · 2025Review
- Proximal Fibula Resection for Tumors-Case Series and Technical Note.Journal of clinical medicine · 2024Article
- Surgical management for massive rotator cuff tears: a network meta-analysis of randomized controlled trials.Burns & trauma · 2024Article
- Public Interest in Shoulder Platelet-Rich Plasma Injections Is Increasing: A 10-Year Google Trends Analysis.Arthroscopy, sports medicine, and rehabilitation · 2023Article
- The role of platelet-rich plasma in shoulder pathologies: a critical review of the literature.EFORT open reviews · 2023Review
- The Number of Surgeons Using Superior Capsular Reconstruction for Rotator Cuff Repair Is Declining.Arthroscopy, sports medicine, and rehabilitation · 2022Article
- Autograft Long Head Biceps Tendon Can Be Used as a Scaffold for Biologically Augmenting Rotator Cuff Repairs.Arthroscopy : the journal of arthroscopic & related surgery : official publication of the Arthroscopy Association of North America and the International Arthroscopy Association · 2022Article
- Systematic Review of Platelet-Rich Plasma for Rotator Cuff Repair: Are We Adhering to the Minimum Information for Studies Evaluating Biologics in Orthopaedics?Orthopaedic journal of sports medicine · 2021Review
- Review
- Article
- Current Biological Strategies to Enhance Surgical Treatment for Rotator Cuff Repair.Frontiers in bioengineering and biotechnology · 2021Review
- No healing improvement after rotator cuff reconstruction augmented with an autologous periosteal flap.Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA · 2019Article
- Biologics and stem cell-based therapies for rotator cuff repair.Annals of the New York Academy of Sciences · 2019Review
- Graft use in the treatment of large and massive rotator cuff tears: an overview of techniques and modes of failure with MRI correlation.Skeletal radiology · 2019Review
- Platelet-rich plasma and the shoulder: clinical indications and outcomes.Current reviews in musculoskeletal medicine · 2018Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purpose of reviewThe purpose of this review was to establish the foundation of the major biologic adjuvants to rotator cuff repairs and review recent scientific findings. RECENT
findingsPlatelet-rich plasma (PRP) overall has no significant impact on functional outcomes and repair integrity, but may be more advantageous in small to medium tears. Further studies should focus on leukocyte-rich versus poor preparations and the use of PRP in patients that are high risk for repair failure. Biologic and synthetic patches or augments provide mechanical stability for large and massive rotator cuff tears and decrease re-tear rates. Mesenchymal stem cells have demonstrated improved healing rates without an impact on outcomes. Cytokines and growth factors show promise in animal models, but require human trials to further evaluate. In massive or revision repairs, allograft or synthetic patch augmentation should be considered. Platelet-rich plasma may have benefit in smaller tears. Further studies are needed to evaluate the value of mesenchymal stem cells and various cytologic chemical signals.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.