ArticleNeurochemical research2018
Analgesic Effect of Methane Rich Saline in a Rat Model of Chronic Inflammatory Pain.
Article in Neurochemical research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
11 citing papers in PubMed, 15 citations in OpenAlex.
- Methane-rich saline ameliorates depressive-like behaviors during chronic unpredictable mild stress (CUMS).Naunyn-Schmiedeberg's archives of pharmacology · 2024Article
- Emodin alleviates arthritis pain through reducing spinal inflammation and oxidative stress.Molecular pain · 2022Article
- Recent Advances in the Role of Nuclear Factor Erythroid-2-Related Factor 2 in Spinal Cord Injury: Regulatory Mechanisms and Therapeutic Options.Frontiers in aging neuroscience · 2022Review
- The role of methane in plant physiology: a review.Plant cell reports · 2020Review
- Methane and Inflammation - A Review (Fight Fire with Fire).Intensive care medicine experimental · 2019Review
- Article
- Methane-Rich Saline: A Potential Resuscitation Fluid for Hemorrhagic Shock.Oxidative medicine and cellular longevity · 2019Article
- Protective Effect of Methane-Rich Saline on Acetic Acid-Induced Ulcerative Colitis via Blocking the TLR4/NF-Oxidative medicine and cellular longevity · 2019Article
- Methane Production and Bioactivity-A Link to Oxido-Reductive Stress.Frontiers in physiology · 2019Review
- Therapeutic effect of methane and its mechanism in disease treatment.Journal of Zhejiang University. Science. BReview
- A narrative review of methane in treating neurological diseases.Medical gas researchReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 4 institutions in 1 country.
Funding
Abstract
How oxidative stress contributes to neuro-inflammation and chronic pain is documented, and methane is reported to protect against ischemia-reperfusion injury in the nervous system via anti-inflammatory and antioxidant properties. We studied whether methane in the form of methane rich saline (MS) has analgesic effects in a monoarthritis (MA) rat model of chronic inflammatory pain. Single and repeated injections of MS (i.p.) reduced MA-induced mechanical allodynia and multiple methane treatments blocked activation of glial cells, decreased IL-1β and TNF-α production and MMP-2 activity, and upregulated IL-10 expression in the spinal cord on day 10 post-MA. Furthermore, MS reduced infiltrating T cells and expression of IFN-γ and suppressed MA-induced oxidative stress (MDA and 8-OHDG), and increased superoxide dismutase and catalase activity. Thus, MS may offer anti-inflammatory and antioxidant effects to reduce chronic inflammatory pain.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.