Evidence map›Paper›PMID 29411176›Full record

ArticleLasers in medical science2018

Label-free imaging for T staging of gastric carcinoma by multiphoton microscopy.

Kexin He, Lili Zhao, Xiaoyang Huang, Ying Ding, Li Liu, Xiang Wang, Min Wang, Yong Zhang, Zhining Fan

Abstract read
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In one paragraph

Article in Lasers in medical science, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.7field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 13 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Kexin HeDigestive Endoscopy Department, The First Affiliated Hospital with Nanjing Medical University, Nanjing, 210029, China.
Lili ZhaoDigestive Endoscopy Department, The First Affiliated Hospital with Nanjing Medical University, Nanjing, 210029, China.
Xiaoyang HuangNational Laboratory of Solid State Microstructure of Nanjing University, Nanjing, 210093, China.
Ying DingDepartment of Pathology, The First Affiliated Hospital with Nanjing Medical University, Nanjing, 210029, China.
Li LiuDigestive Endoscopy Department, The First Affiliated Hospital with Nanjing Medical University, Nanjing, 210029, China.
Xiang WangDigestive Endoscopy Department, The First Affiliated Hospital with Nanjing Medical University, Nanjing, 210029, China.
Min WangDigestive Endoscopy Department, The First Affiliated Hospital with Nanjing Medical University, Nanjing, 210029, China.
Yong ZhangNational Laboratory of Solid State Microstructure of Nanjing University, Nanjing, 210093, China.
Zhining FanDigestive Endoscopy Department, The First Affiliated Hospital with Nanjing Medical University, Nanjing, 210029, China. fanzhining@njmu.edu.cn.ORCID http://orcid.org/0000-0002-4100-912X
Nanjing Medical University · CNCollaborative Innovation Center of Advanced Microstructures · CN

Funding

"333" project of Jiangsu Province BRA2015463Jiangsu Province Key technology research Program BE2016738National Natural Science Foundation of China 81700577The Key Medical Program of Jiangsu Province 2DXKA2016005The Priority Academic Program Development of Jiangsu Higher Education Institutions JX10231802
6 · The paper itself

Abstract

Gastric cancer is one of the most common malignancies worldwide. The accurate diagnosis of tumor invasion depth is critical for therapeutic strategy and prognosis. Without fluorescent labelling, multiphoton microscopy (MPM) imaging could directly reveal tissue architecture based on two-photon excited fluorescence (TPEF) and second harmonic generation (SHG). In this study, we aimed to explore the feasibility of MPM imaging to assess the gastric tumor morphology and infiltration. Unstained slides of 18 fresh gastric tissues with different T staging were examined by multiphoton microscopy. Morphological and quantitative analyses were both conducted. The nuclear area was defined as the area of nuclear boundary. Collagen content was defined as the ratio of SHG pixels to all pixels. Gastric normal and tumor tissues under different T stages visually presented with cellular and subcellular features on fluorescent imaging. The nuclear areas of normal and cancerous cells were 32.01 ± 2.89 and 58.41 ± 6.06 μm

Indexed as

AgedFemaleGastric MucosaHumansMaleMicroscopy, Fluorescence, MultiphotonMiddle AgedNeoplasm StagingStomach NeoplasmsEndoscopyGastric cancerMultiphoton microscopyT stageTumor infiltration depthTumor tissue

Identifiers

PMID29411176
OpenAlexW2790372466

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.