ReviewPharmaceutical research2018
Drugs in Lactation.
Review in Pharmaceutical research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 43 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Clinical Lactation Study on the Exposure to Medicines Via Human Milk: an Umbrella Study Protocol
Maternal Treatment With ACE-inhibitors and Breastfeeding: a Mono-centric Study on the Exposure Through Breast Milk
Who cites it
43 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Efficacy and Safety of Antivirals in Lactating Women with Herpesviridae Infections: A Systematic Review.Viruses · 2025Pooled it
- Population pharmacokinetic modelling of amoxicillin in human breast milk-A contribution from the ConcePTION project.British journal of clinical pharmacology · 2026Article
- Transfer of trastuzumab and pertuzumab into human breast milk: a case report.Cancer chemotherapy and pharmacology · 2026Article
- Cognitive Outcomes of Children Exposed to Selective Serotonin Reuptake Inhibitors Through Breast Milk.JAMA network open · 2025Article
- The Impact of Substance Use Disorder and Drug Transfer into Breast Milk: Implications for Maternal and Infant Health.Pharmaceutics · 2025Review
- Safety and Risks of Antihypertensive Medications During Breastfeeding: A Review of Current Guidelines.Journal of clinical medicine · 2025Review
- Article
- Machine learning approaches for assessing medication transfer to human breast milk.Journal of pharmacokinetics and pharmacodynamics · 2025Article
- Transporters and drug secretion into human breast milk.Expert opinion on drug metabolism & toxicology · 2025Review
- PBPK-Led Assessment of Antimalarial Drug Concentrations in Breastmilk: A Strategy for Optimal Use of Prediction Methods to Guide Decision Making in an Understudied Population.CPT: pharmacometrics & systems pharmacology · 2025Article
- Population pharmacokinetic modelling of cetirizine concentrations in human breast milk-A contribution from the ConcePTION project.Basic & clinical pharmacology & toxicology · 2025Article
- Transfer of Intravenous Remimazolam into Milk of Lactating Sheep and Uptake by Breast-fed Lambs.Current drug metabolism · 2025Article
- Very low enalapril and enalaprilat exposureFrontiers in pharmacology · 2025Article
- Editorial: World breastfeeding week 2024: an obstetric and pediatric pharmacology perspective.Frontiers in pharmacology · 2025Article
- Clopidogrel transfer into human milk: case series - a contribution from the ConcePTION project.Frontiers in pharmacology · 2025Article
- Pragmatic and contextualized methods selection for safety assessment of infant systemic exposure through human milk: the Milk4baby decision tree approach - a contribution from the concePTION project.Frontiers in pharmacology · 2025Article
- Special Populations in Ambulatory Surgery: Oncologic, Lactating, Transgender and Gender Diverse, and Suicidal Ideation.International anesthesiology clinics · 2025Article
- A literature review of drug transport mechanisms during lactation.CPT: pharmacometrics & systems pharmacology · 2024Review
- On placental and lactational transfer of IgG-based therapeutic proteins - Current understanding and knowledge gaps from a clinical pharmacology perspective.Clinical and translational science · 2024Review
- Assessment of Infant Exposure to Antidepressants through Breastfeeding: A Literature Review of Currently Available Approaches.Pharmaceutics · 2024Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
One impediment to breastfeeding is the lack of information on the use of many drugs during lactation, especially newer ones. The principles of drug passage into breastmilk are well established, but have often not been optimally applied prospectively. Commonly used preclinical rodent models for determining drug excretion into milk are very unreliable because of marked differences in milk composition and transporters compared to those of humans. Measurement of drug concentrations in humans remains the gold standard, but computer modeling is promising. New FDA labeling requirements present an opportunity to apply modeling to preclinical drug development in place of conventional animal testing for drug excretion into breastmilk, which should improve the use of medications in nursing mothers.
Indexed as
Identifiers
29411152What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.