Evidence map›Paper›PMID 29411084›Full record

ArticleAnalytical and bioanalytical chemistry2018

Comprehensive targeted and non-targeted lipidomics analyses in failing and non-failing heart.

Ganesh V Halade, Anela Dorbane, Kevin A Ingle, Vasundhara Kain, Jean-Marie Schmitter, Boutayna Rhourri-Frih

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Analytical and bioanalytical chemistry, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.3field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 20 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Review
  6. Big Data Approaches in Heart Failure Research.Current heart failure reports · 2020
    Review
  7. Article
  8. Review
  9. Article
  10. Lipidomics reveals associations between rice quality traits.Metabolomics : Official journal of the Metabolomic Society · 2020
    Article
  11. Article
  12. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 2 countries.

Ganesh V HaladeDivision of Cardiovascular Disease, Department of Medicine, The University of Alabama at Birmingham, 703 19th Street South, MC7755, Birmingham, AL, 35294, USA. ganeshhalade@uabmc.edu.
Anela DorbaneChimie et Biologie des Membranes et Nanoobjets, University of Bordeaux, CNRS UMR 5248, 146, rue Léo Saignat, 33076, Bordeaux, France.
Kevin A IngleDivision of Cardiovascular Disease, Department of Medicine, The University of Alabama at Birmingham, 703 19th Street South, MC7755, Birmingham, AL, 35294, USA.
Vasundhara KainDivision of Cardiovascular Disease, Department of Medicine, The University of Alabama at Birmingham, 703 19th Street South, MC7755, Birmingham, AL, 35294, USA.
Jean-Marie SchmitterChimie et Biologie des Membranes et Nanoobjets, University of Bordeaux, CNRS UMR 5248, 146, rue Léo Saignat, 33076, Bordeaux, France.
Boutayna Rhourri-FrihChimie et Biologie des Membranes et Nanoobjets, University of Bordeaux, CNRS UMR 5248, 146, rue Léo Saignat, 33076, Bordeaux, France. boutayna.frih@u-bordeaux.fr.
University of Alabama at Birmingham · USCentre National de la Recherche Scientifique · FRChimie et Biologie des Membranes et des Nanoobjects · FRInstitut Polytechnique de Bordeaux · FR

Funding

Resolution of Inflammation in Heart Failure Post-Myocardial InfarctionR01HL132989 · NHLBI · UNIVERSITY OF SOUTH FLORIDA · PI HALADE, GANESH V · 2016 to 2020
$1.8M
DHA Mechanisms in Obesity-mediated Cardiac Remodeling Post-Myocardial InfarctionR00AT006704 · NCCIH · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI HALADE, GANESH V · 2013 to 2015
$717k
DHA Mechanisms in Obesity-mediated Cardiac Remodeling Post-Myocardial InfarctionK99AT006704 · NCCIH · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI HALADE, GANESH V · 2011 to 2012
$194k
American Heart Association POST31000008NCCIH NIH HHS K99 AT006704NCCIH NIH HHS R00 AT006704NHLBI NIH HHS R01 HL132989NIH HHS AT006704; HL132989
6 · The paper itself

Abstract

Myocardial infarction (MI) and subsequent progressive heart failure pathology is the major cause of death worldwide; however, the mechanism of this pathology remains unclear. The present work aimed at testing the hypothesis whether the inflammatory response is superimposed with the formation of bioactive lipid resolving molecules at the site of the injured myocardium in acute heart failure pathology post-MI. In this view, we used a robust permanent coronary ligation model to induce MI, leading to decreased contractility index with marked wall thinning and necrosis of the infarcted left ventricle. Then, we applied mass spectrometry imaging (MSI) in positive and negative ionization modes to characterize the spatial distribution of left ventricle lipids in the infarcted myocardium post-MI. After micro-extraction, liquid chromatography coupled to tandem mass spectrometry was used to confirm the structures of the imaged lipids. Statistical tools such as principal component analysis were used to establish a comprehensive visualization of lipid profile changes in MI and no-MI hearts. Resolving bioactive molecules such as resolvin (Rv) D1, RvD5, RvE3, 17-HDHA, LXA

Indexed as

AnimalsDocosahexaenoic AcidsHeartInflammationLipid MetabolismLipidsMaleMass SpectrometryMice, Inbred C57BLMyocardial InfarctionMyocardiumDocosahexaenoic AcidsLipidsresolvin D1resolvin D5Bioactive lipid moleculesIschemic myocardiumLipidsMyocardial infarctionResolution of inflammation

Identifiers

PMID29411084
PMCPMC7837410
OpenAlexW2792280375

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.