Evidence map›Paper›PMID 29410969›Full record

ArticleJournal of immunology research2017

Elevated Serum Level of HMGB1 in Patients with the Antiphospholipid Syndrome.

Valeria Manganelli, Antonella Capozzi, Simona Truglia, Cristiano Alessandri, Emanuela Lococo, Tina Garofalo, Caterina De Carolis, Fabrizio Conti, Guido Valesini, Maurizio Sorice and 2 more

Open access · goldAbstract read
In one paragraph

Article in Journal of immunology research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.7field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 17 citations in OpenAlex.

  1. Review
  2. B Cell Tolerance and Obstetric Antiphospholipid Syndrome.Clinical reviews in allergy & immunology · 2025
    Review
  3. Article
  4. Article
  5. Article
  6. Immunogenic cell stress and death.Nature immunology · 2022
    Review
  7. Article
  8. Article
  9. High-mobility group box 1 is a driver of inflammation throughout pregnancy.American journal of reproductive immunology (New York, N.Y. : 1989) · 2021
    Review
  10. Article
  11. Article
  12. Observational
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 1 country.

Valeria ManganelliDepartment of Experimental Medicine, Sapienza University, Rome, Italy.
Antonella CapozziDepartment of Experimental Medicine, Sapienza University, Rome, Italy.ORCID 0000-0001-6508-7731
Simona TrugliaLupus Clinic, Dipartimento di Medicina Interna e Specialità Mediche, Sapienza University, Rome, Italy.ORCID 0000-0001-9515-2135
Cristiano AlessandriLupus Clinic, Dipartimento di Medicina Interna e Specialità Mediche, Sapienza University, Rome, Italy.ORCID 0000-0003-4149-5321
Emanuela LococoDepartment of Experimental Medicine, Sapienza University, Rome, Italy.
Tina GarofaloDepartment of Experimental Medicine, Sapienza University, Rome, Italy.
Caterina De CarolisGynecology and Obstetrics, "San Giovanni Addolorata" Hospital, Rome, Italy.
Fabrizio ContiLupus Clinic, Dipartimento di Medicina Interna e Specialità Mediche, Sapienza University, Rome, Italy.ORCID 0000-0002-1897-049X
Guido ValesiniLupus Clinic, Dipartimento di Medicina Interna e Specialità Mediche, Sapienza University, Rome, Italy.
Maurizio SoriceDepartment of Experimental Medicine, Sapienza University, Rome, Italy.ORCID 0000-0003-3534-1502
Agostina LongoDepartment of Experimental Medicine, Sapienza University, Rome, Italy.
Roberta MisasiDepartment of Experimental Medicine, Sapienza University, Rome, Italy.ORCID 0000-0002-1181-6190
Sapienza University of Rome · ITAzienda Ospedaliera San Giovanni Addolorata · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Pregnancy problems are common in patients with rheumatic disease; indeed, autoimmune disorders and autoantibodies can affect pregnancy progress and lead to maternal complications. Recent studies have highlighted a close association between HMGB1, chronic inflammation, and autoimmune diseases. Thus, in this investigation, we analyzed serum levels of HMGB1, an alarmin which plays a pivotal role in inducing and enhancing immune cell function. Sera from 30 patients with antiphospholipid syndrome (11 primary and 19 secondary APS), 35 subjects with pregnancy morbidity, and 30 healthy women were analysed for HMGB1 and its putative receptor RAGE (sRAGE) by Western blot and for TNF-

Indexed as

AdolescentAdultAlarminsAntiphospholipid SyndromeFemaleHMGB1 ProteinHumansInflammationMiddle AgedPregnancyPregnancy OutcomeReceptor for Advanced Glycation End ProductsRiskTumor Necrosis Factor-alphaYoung AdultAlarminsHMGB1 ProteinReceptor for Advanced Glycation End ProductsTumor Necrosis Factor-alpha

Identifiers

PMID29410969
PMCPMC5749292
OpenAlexW2777008063

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.