ArticleFrontiers in medicine2017
Active Trachoma Cases in the Solomon Islands Have Varied Polymicrobial Community Structures but Do Not Associate with Individual Non-Chlamydial Pathogens of the Eye.
Article in Frontiers in medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 2 of them syntheses that pooled it.
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Who cites it
13 citing papers in PubMed, 2 syntheses or guidelines pooled it, 20 citations in OpenAlex.
- A search for trachoma in Timor-Leste: no evidence to justify undertaking population-based prevalence surveys.Ophthalmic epidemiology · 2018Pooled it
- A systematic review of historical and contemporary evidence of trachoma endemicity in the Pacific Islands.PloS one · 2018Pooled it
- The Effect of Topical Anesthetics on 16S Ribosomal Ribonucleic Acid Amplicon Sequencing Results in Ocular Surface Microbiome Research.Translational vision science & technology · 2022Trial
- Corneal pannus, Herbert's pits and conjunctival inflammation in older children in Papua New Guinea.Ophthalmic epidemiology · 2024Article
- The Ocular Microbiome: Micro-Steps Towards Macro-Shift in Targeted Treatment? A Comprehensive Review.Microorganisms · 2024Review
- Investigating the Ocular Surface Microbiome: What Can It Tell Us?Clinical ophthalmology (Auckland, N.Z.) · 2023Review
- Shotgun metagenomic sequencing analysis of ocular surface microbiome in Singapore residents with mild dry eye.Frontiers in medicine · 2022Article
- Ocular Chlamydia trachomatis infection, anti-Pgp3 antibodies and conjunctival scarring in Vanuatu and Tarawa, Kiribati before antibiotic treatment for trachoma.The Journal of infection · 2020Article
- Pgp3 seroprevalence and associations with active trachoma and ocular Chlamydia trachomatis infection in Malawi: cross-sectional surveys in six evaluation units.PLoS neglected tropical diseases · 2019Article
- Article
- Conjunctival Microbiome-Host Responses Are Associated With Impaired Epithelial Cell Health in Both Early and Late Stages of Trachoma.Frontiers in cellular and infection microbiology · 2019Article
- The utility of serology for elimination surveillance of trachoma.Nature communications · 2018Article
- Conjunctival transcriptome profiling of Solomon Islanders with active trachoma in the absence of Chlamydia trachomatis infection.Parasites & vectors · 2018Article
Corrections and comments
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Authors and funding
13 authors at 2 institutions in 2 countries.
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Abstract
backgroundSeveral non-chlamydial microbial pathogens are associated with clinical signs of active trachoma in trachoma-endemic communities with a low prevalence of ocular
methodsWe studied DNA from conjunctival swabs collected from 257 Solomon Islanders with active trachoma and matched controls. Droplet digital PCR was used to test for pathogens suspected to be able to induce follicular conjunctivitis. Polymicrobial community diversity and composition were studied by sequencing of hypervariable regions of the 16S ribosomal ribonucleic acid gene in a subset of 54 cases and 53 controls.
resultsAlthough DISCUSSION: It is unlikely that the prevalent trachoma-like follicular conjunctivitis in this region of the Solomon Islands has a dominant bacterial etiology. Before implementing community-wide azithromycin distribution for trachoma, policy makers should consider that clinical signs of trachoma can be observed in the absence of any detectable azithromycin-susceptible organism.
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