Evidence map›Paper›PMID 29410735›Full record

ReviewOxidative medicine and cellular longevity2017

The Crosstalk between ROS and Autophagy in the Field of Transplantation Medicine.

Anne C Van Erp, Dane Hoeksma, Rolando A Rebolledo, Petra J Ottens, Ina Jochmans, Diethard Monbaliu, Jacques Pirenne, Henri G D Leuvenink, Jean-Paul Decuypere

Abstract readReview
In one paragraph

Review in Oxidative medicine and cellular longevity, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. [Research progress of acetaldehyde dehydrogenase 2 in liver diseases].Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology · 2022
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  13. Organ-specific metabolic profiles of the liver and kidney during brain death and afterwards during normothermic machine perfusion of the kidney.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2020
    Article
  14. Article
  15. Article
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  18. Article
  19. Autophagy and Age-Related Eye Diseases.BioMed research international · 2019
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Anne C Van ErpDepartment of Surgery, University Medical Center Groningen, Groningen, Netherlands.
Dane HoeksmaDepartment of Surgery, University Medical Center Groningen, Groningen, Netherlands.
Rolando A RebolledoDepartment of Surgery, University Medical Center Groningen, Groningen, Netherlands.
Petra J OttensDepartment of Surgery, University Medical Center Groningen, Groningen, Netherlands.
Ina JochmansLaboratory of Abdominal Transplantation, Department of Microbiology and Immunology, KU Leuven, Leuven, Belgium.
Diethard MonbaliuLaboratory of Abdominal Transplantation, Department of Microbiology and Immunology, KU Leuven, Leuven, Belgium.
Jacques PirenneLaboratory of Abdominal Transplantation, Department of Microbiology and Immunology, KU Leuven, Leuven, Belgium.
Henri G D LeuveninkDepartment of Surgery, University Medical Center Groningen, Groningen, Netherlands.
Jean-Paul DecuypereLaboratory of Abdominal Transplantation, Department of Microbiology and Immunology, KU Leuven, Leuven, Belgium.ORCID 0000-0001-6050-599X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Many factors during the transplantation process influence posttransplant graft function and survival, including donor type and age, graft preservation methods (cold storage, machine perfusion), and ischemia-reperfusion injury. Successively, they will lead to cellular and molecular alterations that determine cell and ultimately organ fate. Oxidative stress and autophagy are implicated in posttransplant outcome since they are both affected by the stress responses triggered in each step (donor, preservation, and recipient) of the transplantation process. Furthermore, oxidative stress influences autophagy and vice versa. Interestingly, both processes have positive as well as negative effects on graft outcome, suggesting they are tightly linked during the transplantation process. In this review, we discuss the importance, regulation and crosstalk of oxidative signals, and autophagy in the field of transplantation medicine.

Indexed as

AutophagyHumansReactive Oxygen SpeciesTransplantationReactive Oxygen Species

Identifiers

PMID29410735
PMCPMC5749284

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.