Evidence map›Paper›PMID 29410614›Full record

ArticleFrontiers in molecular neuroscience2018

Farnesylation of the Transducin G Protein Gamma Subunit Is a Prerequisite for Its Ciliary Targeting in Rod Photoreceptors.

Celine Brooks, Joseph Murphy, Marycharmain Belcastro, Daniel Heller, Saravanan Kolandaivelu, Oleg Kisselev, Maxim Sokolov

Open access · goldAbstract read
In one paragraph

Article in Frontiers in molecular neuroscience, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.1field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 20 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Article
  6. Article
  7. Functional compartmentalization of photoreceptor neurons.Pflugers Archiv : European journal of physiology · 2021
    Review
  8. Compartmentalization of Photoreceptor Sensory Cilia.Frontiers in cell and developmental biology · 2021
    Review
  9. Review
  10. Article
  11. Article
  12. Archaeal Unfoldase Counteracts Protein Misfolding Retinopathy in Mice.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2018
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Celine BrooksDepartment of Ophthalmology, West Virginia University, Morgantown, WV, United States.
Joseph MurphyDepartment of Ophthalmology, West Virginia University, Morgantown, WV, United States.
Marycharmain BelcastroDepartment of Ophthalmology, West Virginia University, Morgantown, WV, United States.
Daniel HellerDepartment of Ophthalmology, West Virginia University, Morgantown, WV, United States.
Saravanan KolandaiveluDepartment of Ophthalmology, West Virginia University, Morgantown, WV, United States.
Oleg KisselevDepartment of Ophthalmology, Saint Louis University, St. Louis, MO, United States.
Maxim SokolovDepartment of Ophthalmology, West Virginia University, Morgantown, WV, United States.
West Virginia University · USSaint Louis University · US

Funding

G-proteins and mechanisms of signal transduction in visionR21EY018107 · NEI · SAINT LOUIS UNIVERSITY · PI KISSELEV, OLEG G · 2009 to 2010
$387k
NEI NIH HHS R21 EY018107
6 · The paper itself

Abstract

Primary cilia are microtubule-based organelles, which protrude from the plasma membrane and receive a wide range of extracellular signals. Various cilia use G protein-coupled receptors (GPCRs) for the detection of these signals. For instance, vertebrate rod photoreceptors use their cilia (also called outer segments) as antennae detecting photons by GPCR rhodopsin. Rhodopsin recognizes incoming light and activates its G protein, transducin, which is composed of three subunits α, β, and γ. Similar to all G protein γ subunits, the transducin Gγ

Indexed as

ciliumfarnesylationheterotrimeric G proteinprotein traffickingretinarod photoreceptor

Identifiers

PMID29410614
PMCPMC5787109
OpenAlexW2800507237

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.