Evidence map›Paper›PMID 29410448›Full record

Trial reportScientific reports2018

Intestinal microbiota development and gestational age in preterm neonates.

Katri Korpela, Elin W Blakstad, Sissel J Moltu, Kenneth Strømmen, Britt Nakstad, Arild E Rønnestad, Kristin Brække, Per O Iversen, Christian A Drevon, Willem de Vos

Abstract readMulticenter StudyRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 183 papers, 9 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
183citing papers in PubMed, 9 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

183 citing papers in PubMed, 9 syntheses or guidelines pooled it.

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123 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Katri KorpelaImmunobiology Research Programme, Department of Bacteriology and Immunology, University of Helsinki, Helsinki, Finland. katri.korpela@helsinki.fi.
Elin W BlakstadDepartment of Pediatric and Adolescent Medicine, Akershus University Hospital and Institute for Clinical Medicine, Campus Ahus, University of Oslo, Nordbyhagen, Nordbyhagen, Norway.
Sissel J MoltuDepartment of Neonatal Intensive Care, Division of Paediatric and Adolescent Medicine, Oslo University Hospital, Ullevål, Oslo, Norway.
Kenneth StrømmenDepartment of Nutrition, Institute of Basic Medical Sciences, Faculty of Medicine, University of Oslo, Oslo, Norway.
Britt NakstadDepartment of Pediatric and Adolescent Medicine, Akershus University Hospital and Institute for Clinical Medicine, Campus Ahus, University of Oslo, Nordbyhagen, Nordbyhagen, Norway.
Arild E RønnestadDepartment of Neonatal Intensive Care, Division of Paediatric and Adolescent Medicine, Oslo University Hospital, Rikshospitalet, Oslo, Norway.
Kristin BrækkeDepartment of Neonatal Intensive Care, Division of Paediatric and Adolescent Medicine, Oslo University Hospital, Ullevål, Oslo, Norway.
Per O IversenDepartment of Nutrition, Institute of Basic Medical Sciences, Faculty of Medicine, University of Oslo, Oslo, Norway.
Christian A DrevonDepartment of Nutrition, Institute of Basic Medical Sciences, Faculty of Medicine, University of Oslo, Oslo, Norway.
Willem de VosImmunobiology Research Programme, Department of Bacteriology and Immunology, University of Helsinki, Helsinki, Finland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The intestinal microbiota is an important contributor to the health of preterm infants, and may be destabilized by a number of environmental factors and treatment modalities. How to promote the development of a healthy microbiota in preterm infants is largely unknown. We collected fecal samples from 45 breastfed preterm very low birth weight (birth weight < 1500 g) infants from birth until 60 days postnatal age to characterize the intestinal microbiota development during the first weeks of life in preterm infants. Fecal microbiota composition was determined by 16S rRNA amplicon sequencing. The main driver of microbiota development was gestational age; antibiotic use had strong but temporary effects and birth mode had little influence. Microbiota development proceeded in four phases indicated by the dominance of Staphylococcus, Enterococcus, Enterobacter, and finally Bifidobacterium. The Enterococcus phase was only observed among the extremely premature infants and appeared to delay the microbiota succession. The results indicate that hospitalized preterm infants receiving breast milk may develop a normal microbiota resembling that of term infants.

Indexed as

Gestational AgeAnti-Bacterial AgentsBifidobacteriumBreast FeedingEnterobacterEnterococcusFecesFemaleGastrointestinal MicrobiomeHumansInfantInfant, NewbornInfant, PrematureInfant, Very Low Birth WeightMaleRNA, Ribosomal, 16SAnti-Bacterial AgentsRNA, Ribosomal, 16S

Identifiers

PMID29410448
PMCPMC5802739

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.