Evidence map›Paper›PMID 29410406›Full record

ArticleNature communications2018

Cryo-EM structure of 5-HT

Sandip Basak, Yvonne Gicheru, Amrita Samanta, Sudheer Kumar Molugu, Wei Huang, Maria la de Fuente, Taylor Hughes, Derek J Taylor, Marvin T Nieman, Vera Moiseenkova-Bell and 1 more

Open access · goldAbstract read
In one paragraph

Article in Nature communications, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 60 papers.

0numbers the graph read from it
0cells of the map it votes in
60citing papers in PubMed
7.0field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

60 citing papers in PubMed, 116 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Asymmetric gating of a homopentameric ion channel GLIC revealed by cryo-EM.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  5. Article
  6. Predicted conformations of 5-HT3 receptor ion channels are modified by subunit D.Computational and structural biotechnology journal · 2025
    Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Structural basis for partial agonism in 5-HTNature structural & molecular biology · 2024
    Article
  14. Article
  15. Article
  16. Article
  17. 5-HTInternational journal of molecular sciences · 2023
    Article
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 1 institution in 1 country.

Sandip BasakDepartment of Physiology and Biophysics, Case Western Reserve University, Cleveland, OH, 44106-4970, USA.ORCID http://orcid.org/0000-0003-4018-8020
Yvonne GicheruDepartment of Physiology and Biophysics, Case Western Reserve University, Cleveland, OH, 44106-4970, USA.
Amrita SamantaDepartment of Physiology and Biophysics, Case Western Reserve University, Cleveland, OH, 44106-4970, USA.
Sudheer Kumar MoluguDepartment of Pharmacology, Case Western Reserve University, Cleveland, OH, 44106-4970, USA.ORCID http://orcid.org/0000-0001-9939-1950
Wei HuangDepartment of Pharmacology, Case Western Reserve University, Cleveland, OH, 44106-4970, USA.
Maria la de FuenteDepartment of Pharmacology, Case Western Reserve University, Cleveland, OH, 44106-4970, USA.
Taylor HughesDepartment of Pharmacology, Case Western Reserve University, Cleveland, OH, 44106-4970, USA.
Derek J TaylorDepartment of Pharmacology, Case Western Reserve University, Cleveland, OH, 44106-4970, USA.
Marvin T NiemanDepartment of Pharmacology, Case Western Reserve University, Cleveland, OH, 44106-4970, USA.
Vera Moiseenkova-BellDepartment of Physiology and Biophysics, Case Western Reserve University, Cleveland, OH, 44106-4970, USA.ORCID http://orcid.org/0000-0002-0589-4053
Sudha ChakrapaniDepartment of Physiology and Biophysics, Case Western Reserve University, Cleveland, OH, 44106-4970, USA. Sudha.chakrapani@case.edu.
Case Western Reserve University · US

Funding

TISSUE CULTURE AND HYBRIDOMA MODULEP30EY011373 · NEI · CASE WESTERN RESERVE UNIVERSITY · PI Irina A Pikuleva · 1997 to 2026
$17.7M
The role of protease activated receptors on platelets.R01HL098217 · NHLBI · CASE WESTERN RESERVE UNIVERSITY · PI NIEMAN, MARVIN THOMAS · 2010 to 2024
$4.6M
Structural Insights into TRPV Channel GatingR01GM103899 · NIGMS · UNIVERSITY OF PENNSYLVANIA · PI MOISEENKOVA-BELL, VERA · 2013 to 2021
$3.2M
Induction of cancer cell death by selective DNA misincorporationDP2CA186571 · NCI · CASE WESTERN RESERVE UNIVERSITY · PI TAYLOR, DEREK JAMES · 2013 to 2014
$2.6M
MOLECULAR MECHANISMS OF DESENSITIZATION AND DRUG MODULATION IN LIGAND-GATED ION CHANNELSR01GM108921 · NIGMS · CASE WESTERN RESERVE UNIVERSITY · PI CHAKRAPANI, SUDHA · 2014 to 2018
$1.9M
STRUCTURE, FUNCTION, AND MODULATION OF SERORTONIN (3A) RECEPTORSR01GM131216 · NIGMS · CASE WESTERN RESERVE UNIVERSITY · PI CHAKRAPANI, SUDHA · 2019 to 2019
$442k
NCI NIH HHS DP2 CA186571NEI NIH HHS P30 EY011373NHLBI NIH HHS R01 HL098217NIGMS NIH HHS R01 GM103899NIGMS NIH HHS R01 GM108921NIGMS NIH HHS R01 GM131216
6 · The paper itself

Abstract

Serotonin receptors (5-HT

Indexed as

Cryoelectron MicroscopyAnimalsCloning, MolecularElectrophysiologyFemaleIonsLigandsMiceOocytesProtein ConformationProtein DomainsReceptors, Serotonin, 5-HT3Recombinant ProteinsSerotoninXenopus laevisIonsLigandsReceptors, Serotonin, 5-HT3Recombinant ProteinsSerotonin

Identifiers

PMID29410406
PMCPMC5802770
OpenAlexW2796317660

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.